transcription factor TBX5, (T-box protein 5) is a protein that in humans is encoded by the TBX5 gene. Abnormalities in the TBX5 gene can result in altered...

conduction disease, both or neither. Mutations in the TBX5 gene cause Holt–Oram syndrome. The TBX5 gene produces a protein that is critical for the proper...

(December 2014). "Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes)". BMC Evolutionary...

Genes encoding T-box proteins include: TBXT (TBXT) the first found (in mice) TBR1 (TBR1) TBX1 (TBX1) TBX2 (TBX2) TBX3 (TBX3) TBX4 (TBX4) TBX5 (TBX5)...

genes that appears to be necessary for specification of the developing hindlimb, whereas their absence results in forelimb development.Tbx4 and Tbx5 appear...

downregulated in non-dun horses compared to dun horses, while the neighboring gene, TBX5, was expressed in about the same amount. In dun horses, the pattern of...

differently expressed genes: a hindlimb-development gene called PITX1 is less active than normal, and a forelimb-development gene called Tbx5 that normally develops...

morphogenesis disrupted. NKX2-5 has been shown to interact with GATA4 and TBX5. NKX2-5 is a transcription factor that regulates heart development from the...

Tbx4/Tbx5 or FGF-8/FGF-10 has the ability to cause a child to be born without one or more limbs. A common syndrome seen with a mutation these genes is Tetra-Amelia...

factor GATA4 forms a complex with the TBX5 which interacts with MYH6. Another factor, the homeobox (developmental) gene, NKX2-5 also interacts with MYH6....

the genus Euryapteryx is published by Huynen et al. (2014). A study of tbx5 gene of the moa from the genus Dinornis is published by Huynen et al. (2014)...

addition to this, Lbh overexpression leads to the repression of Nkx2.5 and Tbx5, important regulators in cardiogenesis in developing embryos. The importance...

Nkx2-5 and Tbx5. GATA4 is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also...

demonstrated that Osr1 is a direct downstream target of Tbx5 in the second heart field and establish a Tbx5-Osr1 pathway parallel to Hh signaling required for...

the lungs, skin, ear and salivary glands. During the limb development Tbx4/Tbx5 stimulate the production of FGF10 in the lateral plate mesoderm where it...

protein of unknown function found in Homo sapiens encoded by the TMEM247 gene. Notable in the protein are two transmembrane regions near the c-terminus...

also been reported to bind T-box 5 protein (Tbx5) in cardiac tissues as well as genetically interact with Tbx5 in mouse limb development. Other binding partners...

features for gibbons to adapt to their new environment. One of them is TBX5, which is a gene that is required for the development of the front extremities or...

different variants associated with transcription factor coding-genes, such as TBX3 and TBX5, NKX2-5 o PITX2, which are involved in cardiac conduction regulation...

ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4". Development. 125 (1): 51–60. doi:10.1242/dev.125.1.51. PMID 9389663...

Drosophila or zebrafish. In humans, two T-box genes are involved in inherited disorders: mutations in TBX5 cause Holt–Oram syndrome, whereas mutations in...

specified by expression of certain Hox genes, a subset of homeotic genes, and T-box transcription factors – Tbx5 for forelimb or wing development, and...

factors Gata4 and Tbx5, which interact with Baf60c. Collectively, these proteins redirect SWI/SNF to activate the cardiac program of gene expression. Targeted...

in mice, axial (lengthwise) cues from the intermediate mesoderm produces Tbx5, which subsequently signals to the same mesoderm to produce Fgf10. Fgf10...

ENSG00000121075 T-box Known motif – High-throughput in vitro [909] TVACACCT TBX5 ENSG00000089225 T-box Known motif – High-throughput in vitro [910] TVACACCT...

cells (Atoh1 and MathI) non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c) Through excision: B-cell precursors → hematopoietic...

"Statistics & download files". www.genenames.org. HUGO Gene Nomenclature Committee. 1 October 2024. Retrieved 1 October 2024....

a member of the Tbx2 subfamily which includes Tbx2, Tbx4 and Tbx5. The human TBX3 gene maps to chromosome 12 at position 12q23-24.1 and consists of 7...

Model of Holt-Oram Syndrome Defines Roles of the T-box Transcription Factor Tbx5 in Cardiogenesis and Disease". Cell. 106 (6): 709–721. doi:10.1016/s0092-8674(01)00493-7...

identified associations: they are associated with genes that encode transcription factors, such as TBX3 and TBX5, NKX2-5 or PITX2, involved in the regulation...