TEK tyrosine kinase (redirect from Tie2)
202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor. The TEK receptor tyrosine kinase is expressed...
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Angiopoietin receptor (redirect from TIE2)
human Ang4). Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by...
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encoded by the ANGPT2 gene. Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1...
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chronic lesions (nevi). BRBNS is caused by somatic mutations in the TEK (TIE2) gene. It was described by William Bennett Bean in 1958. BRBNS is a venous...
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Yancopoulos, George D (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171–80. doi:10...
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Retrieved 2022-05-29. Zadeh, Gelareh (2007). Role of angiopoietins and Tie2/TEK in astrocytoma angiogenesis (Thesis). OCLC 234132296. "Dr. Gelareh Zadeh"...
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Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment...
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work on the role of macrophages in cancer progression and the discovery of Tie2-expressing angiogenic monocytes. De Palma obtained a master's degree in biology...
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angiogenic switch. A class of TAMs expressing Tie2 have been shown to induce tumor angiogenesis. Tie2+ TAMs associate with blood vessels through angiopoietin-2...
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et al. (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7): 1161–9. doi:10...
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TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science...
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(BEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and KIT, RET, TIE2 and FLT3), that also inhibits T135I Bcr-Abl kinase. T135I positive Chronic...
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use EPCR of the host as a receptor. CD202b Angiopoietin-1 receptor, TEK or TIE2; encoded by the TEK gene. TEK receptor tyrosine kinase is expressed almost...
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signaling. Tie-2/Ang-1 signaling activates β1-integrin and N-cadherin in LSK-Tie2+ cells and promotes hematopoietic stem cell (HSC) interactions with extracellular...
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Sydney, Australia, Affiliate Professor 2009–present Discoveries of Tie1, Tie2, and angiopoietins, that play the key roles in the blood vessel formation...
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(2019-07-08). "Transcriptome assembly from long-read RNA-seq alignments with StringTie2". bioRxiv: 694554. doi:10.1101/694554. Retrieved 27 August 2019. Gehlenborg...
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Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis". Scientific Reports. 7 (1): 11198. Bibcode:2017NatSR...
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ARIAD Pharmaceuticals Bcr-Abl, BEGFR, PDGFR, FGFR, EPH, SRC, c-KIT, RET, TIE2, FLT3 T315I-positive Chronic myelogenous leukaemia and T315I-positive-Acute...
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of more than 200 journal articles, including multiple publications on how Tie2 deficits are related to sepsis, blood-retinal barrier damage, and an imbalance...
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and its receptor molecule Tie2 has been implicated in angiogenesis of tumors in both humans and mice. Upregulation of Tie2 has been shown to occur under...
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et al. (1995). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Nature. 376 (6535): 70–74. Bibcode:1995Natur...
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1016/S0898-6568(00)00073-5. PMID 10822173. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene...
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such as myeloid-derived suppressor cells, tumor-associated macrophages, and TIE2-expressing monocytes contribute to therapy resistance. In mouse tumor models...
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hemangioblasts come from the expression of various genes such as CD34 and Tie2 by both lineages. The fact that this expression was seen in both EC and HPC...
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Sasaki H, Daly R, Alitalo K, Dumont DJ (Oct 1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell...
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PMID 9748281. Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell...
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increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb...
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addition to the previously mentioned signals that induce HSC migration, TIE2-angiopoietin and CD44-E-cadherin binding appears to be important for this...
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MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res...
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and Jagged1). This has been shown in vitro and in vivo. Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in...
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