202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor. The TEK receptor tyrosine kinase is expressed...

human Ang4). Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by...

encoded by the ANGPT2 gene. Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1...

chronic lesions (nevi). BRBNS is caused by somatic mutations in the TEK (TIE2) gene. It was described by William Bennett Bean in 1958. BRBNS is a venous...

Yancopoulos, George D (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171–80. doi:10...

Retrieved 2022-05-29. Zadeh, Gelareh (2007). Role of angiopoietins and Tie2/TEK in astrocytoma angiogenesis (Thesis). OCLC 234132296. "Dr. Gelareh Zadeh"...

Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment...

work on the role of macrophages in cancer progression and the discovery of Tie2-expressing angiogenic monocytes. De Palma obtained a master's degree in biology...

angiogenic switch. A class of TAMs expressing Tie2 have been shown to induce tumor angiogenesis. Tie2+ TAMs associate with blood vessels through angiopoietin-2...

et al. (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7): 1161–9. doi:10...

TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science...

(BEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and KIT, RET, TIE2 and FLT3), that also inhibits T135I Bcr-Abl kinase. T135I positive Chronic...

use EPCR of the host as a receptor. CD202b Angiopoietin-1 receptor, TEK or TIE2; encoded by the TEK gene. TEK receptor tyrosine kinase is expressed almost...

signaling. Tie-2/Ang-1 signaling activates β1-integrin and N-cadherin in LSK-Tie2+ cells and promotes hematopoietic stem cell (HSC) interactions with extracellular...

Sydney, Australia, Affiliate Professor 2009–present Discoveries of Tie1, Tie2, and angiopoietins, that play the key roles in the blood vessel formation...

(2019-07-08). "Transcriptome assembly from long-read RNA-seq alignments with StringTie2". bioRxiv: 694554. doi:10.1101/694554. Retrieved 27 August 2019. Gehlenborg...

Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis". Scientific Reports. 7 (1): 11198. Bibcode:2017NatSR...

ARIAD Pharmaceuticals Bcr-Abl, BEGFR, PDGFR, FGFR, EPH, SRC, c-KIT, RET, TIE2, FLT3 T315I-positive Chronic myelogenous leukaemia and T315I-positive-Acute...

of more than 200 journal articles, including multiple publications on how Tie2 deficits are related to sepsis, blood-retinal barrier damage, and an imbalance...

and its receptor molecule Tie2 has been implicated in angiogenesis of tumors in both humans and mice. Upregulation of Tie2 has been shown to occur under...

et al. (1995). "Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation". Nature. 376 (6535): 70–74. Bibcode:1995Natur...

1016/S0898-6568(00)00073-5. PMID 10822173. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene...

such as myeloid-derived suppressor cells, tumor-associated macrophages, and TIE2-expressing monocytes contribute to therapy resistance. In mouse tumor models...

hemangioblasts come from the expression of various genes such as CD34 and Tie2 by both lineages. The fact that this expression was seen in both EC and HPC...

Sasaki H, Daly R, Alitalo K, Dumont DJ (Oct 1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell...

PMID 9748281. Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell...

increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb...

addition to the previously mentioned signals that induce HSC migration, TIE2-angiopoietin and CD44-E-cadherin binding appears to be important for this...

MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res...

and Jagged1). This has been shown in vitro and in vivo. Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in...