channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene. The protein encoded by this gene is a non-selective...
7 KB (984 words) - 09:03, 22 December 2023
cofactor. ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 channel. cADPR also binds to TPRM2, and the...
5 KB (337 words) - 19:07, 25 March 2024
channel, among others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major...
49 KB (5,517 words) - 22:16, 16 July 2024
TRAPPC10: encoding protein Trafficking protein particle complex subunit 10 TRPM2: encoding protein transient receptor potential cation channel subfamily...
34 KB (3,086 words) - 10:35, 27 June 2024
magnesium. The mechanism of activation also varies greatly among TRPM channels. TRPM2 is activated by ADP-ribose adenosine 5'-diphosphoribose and functions as...
7 KB (821 words) - 22:40, 16 July 2024
cells to produce a variety of cytokines. CD38 activation cooperates with TRPM2 channels to initiate physiological responses such as cell volume regulation...
35 KB (3,825 words) - 06:11, 5 June 2024
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin External IDs OMIM: 185430; MGI: 88423; HomoloGene: 1382; GeneCards:...
22 KB (2,433 words) - 05:09, 24 January 2024
converted to adenosine diphosphate ribose, which binds and activates the TRPM2 ion channel. The reaction is catalyzed by ribose-5-phosphate adenylyltransferase...
15 KB (1,499 words) - 14:28, 14 July 2024
critical step in muscle contraction. cADPR also acts as an agonist for the TRPM2 channel, but less potently than ADPR. cADPR and ADPR act synergistically...
12 KB (1,183 words) - 14:06, 24 November 2023
Q9Y210 17468 TRPC7 HGNC:20754 Q9HCX4 17469 TRPM1 HGNC:7146 Q7Z4N2 17470 TRPM2 HGNC:12339 O94759 17471 TRPM3 HGNC:17992 Q9HCF6 17472 TRPM4 HGNC:17993 Q8TD43...
242 KB (17 words) - 23:17, 27 April 2024
voltage gated ion channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8 TRPV1; TRPV2; TRPV3; TRPV4; TRPV5;...
19 KB (1,692 words) - 03:53, 29 November 2023
conformation. Y Kim, J Chen. Science 359 (6378), 915-919 Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation. Z Zhang...
15 KB (1,715 words) - 16:38, 24 March 2024
ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels". The Journal of Biological Chemistry. 280 (7): 6138–48...
10 KB (1,357 words) - 15:38, 22 August 2023
TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2...
2 KB (162 words) - 11:35, 31 October 2023
TRPA (channel) TRPC TRPC1 TRPC2 TRPC3 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML TRPN TRPP TRPP3 TRPV TRPV1 TRPV2...
15 KB (1,545 words) - 11:10, 28 December 2023
retinopathy. TMEM217 was also found to have similar expression patterns as TRPM2, a biomarker linked to breast carcinoma. Expression profiles have also linked...
11 KB (1,089 words) - 08:48, 30 April 2024