U.S. Highway 1 (US 1) is a 170.540-mile (274.458 km) north–south U.S. Highway that crosses South Carolina from southwest to northeast and connects the...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Highway 178 (US 178) is a spur of U.S. Highway 78. It currently runs for 240.49 miles (387.03 km) from Dorchester, South Carolina, at U.S. Highway...

U.S. Route 276 (US 276) is a United States highway that runs for 106.4 miles (171.2 km) from Mauldin, South Carolina to Cove Creek, North Carolina. It...

U.S. Route 176 (US 176) is a spur of US 76 in the U.S. states of North Carolina and South Carolina. The U.S. Highway runs 237.98 miles (382.99 km) from...

U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78...

U.S. Route 521 (US 521) is a north–south United States Highway that traverses 177.3 miles (285.3 km), from Georgetown, South Carolina, to Charlotte, North...

U.S. Route 123 (US 123) is a spur of US 23 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 75.12 miles (120.89 km) from US 23,...

U.S. Route 701 (US 701) is an auxiliary route of US 1 in the U.S. states of South Carolina and North Carolina. The U.S. Highway runs 171.45 miles (275...

U.S. Route 76 (US 76) is an east–west U.S. highway in the U.S. state of South Carolina. Being one of the longest and most important highways in the state...

In North Carolina, US 1 runs for 174.1 miles (280.2 km) across the central region of the state. The highway enters North Carolina from South Carolina...

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park,...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

U.S. Route 301 (US 301) is a 189.704-mile (305.299 km) U.S. Highway that travels north–south from the Savannah River southwest of Allendale to Hamer approaching...

routes of U.S. Route 17 (US 17) have existed: 3 in Florida, 6 in South Carolina, 17 in North Carolina, and 6 in Virginia. U.S. Highway 17 Truck (US 17...

original route through South Carolina was 288 miles (463 km) long. At the time, U.S. Highways in South Carolina used a dual-numbering system; US 17 was...

Delaware Route 1 to Sarasota, Florida, at U.S. Route 41. It passes through the states of Delaware, Maryland, Virginia, North Carolina, South Carolina, Georgia...

routes of U.S. Route 1 (US 1) exist, from Florida to Maine. In order from south to north, separated by type, these special routes are as follows. U.S...

Template:Attached KML/U.S. Route 25 in South Carolina KML is not from Wikidata Media related to U.S. Route 25 in South Carolina at Wikimedia Commons US 25 at Virginia...

U.S. Route 278 (US 278) is a 146.130-mile (235.173 km) east–west United States highway that traverses through the South Carolina Lowcountry, from North...

special routes of U.S. Route 52 exist, from North Dakota to South Carolina. In order from northwest to southeast, they are as follows. U.S. Route 52 Business...

U.S. Route 15 or U.S. Highway 15 (US 15) is a 791.71-mile-long (1,274.13 km) United States Numbered Highway, serving the states of South Carolina, North...

U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km). Its western terminus is at US...

U.S. Route 52 (US 52) is an east–west United States Numbered Highway that runs for 159.960-mile (257.431 km) from Charleston to the North Carolina state...

U.S. Route 78 (US 78) is a 142.207-mile (228.860 km) U.S. highway that travels from Cash, Arkansas to Charleston, South Carolina. In the U.S. state of...

U.S. Route 117 (US 117) is a north–south United States Highway located completely within the state of North Carolina. A spur route of US 17, the highway...

usual "Bypass" (state maps confirm it is the mainline route). At South Carolina Highway 81 (SC 81), US 29 takes a left turn and follows briefly before taking...