V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. It is a driver mutation in a proportion...

non-small-cell lung cancer. BRAF-V600E mutation are present in 57% of Langerhans cell histiocytosis patients. The V600E mutation is a likely driver mutation...

by the US Food and Drug Administration for the treatment of people with V600E mutated metastatic melanoma. It was approved for medical use in the European...

metastatic melanoma with BRAF V600E mutation. Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic...

binimetinib for the treatment of people with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma. In October 2023, the US Food and Drug...

metastatic BRAF V600E or V600K mutation-positive melanoma. In October 2023, it was approved by the FDA for treatment of NSCLC with a BRAF V600E mutation in...

adjacent soft tissues is required. BRAF V600E gene and SMO gene mutations have been found in ameloblastomas. V600E mutation is also seen in other malignant...

pathway − if the B-Raf has the common V600E mutation. Vemurafenib only works in melanoma patients whose cancer has a V600E BRAF mutation (that is, at amino...

approved after showing dramatic efficacy in ECD patients harboring the BRAF V600E mutation. Cobimetinib, an oral inhibitor of MEK1 and MEK2, was approved...

urticaria (CIU), and nasal polyps. Zelboraf (vemurafenib), for late-stage V600E BRAF mutation-positive melanoma. Zenapax (daclizumab), for the prevention...

associated (P=0.0005) with BRAF V600E mutation. According to recent studies, papillary cancers carrying the common V600E mutation tend to have a more aggressive...

encorafenib for the treatment of patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma. Cobimetinib or XL518, approved by US...

effecting the mitochondria. With its unique mechanism, effective also in BRAF V600E mutation cell lines, mensacarcin is a promising model for the development...

does not necessarily imply causation. A 2011 study identified somatic BRAF V600E mutations in all 47 HCL patients studied, and no such mutations in the 193...

et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9): e13447...

approved dabrafenib as a single agent treatment for patients with BRAF V600E mutation-positive advanced melanoma. Some researchers believe that combination...

dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF V600E mutation MEK inhibitors (trametinib, MEK162) are used in experiments, often...

action. Kundu et al.[citation needed] further showed that inhibition of BRAF V600E activity by indole-3-carbinol resulted in downregulation of MITF-M by downstream...

et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9): e13447...

accelerated DNAm age in breast cancer. Colorectal cancer samples with a BRAF (V600E) mutation or promoter hypermethylation of the mismatch repair gene MLH1...

McClain, Kenneth L.; Allen, Carl E. (10 December 2011). "1372 Frequent BRAF V600E Mutations Are Identified in CD207+ Cells in LCH Lesions, but BRAF Status...

cells, similar to the monoclonal cells in Hairy cell leukemia, may have the V600E mutation in the BRAF gene. Patients with this lymphoma commonly have enlarged...

(January 2009). "CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations". Oncogene. 28 (1): 85–94. doi:10.1038/onc.2008.362. PMC 2898184...

(chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125 (ovarian cancer), CA19.9 (pancreatic...

Pharmaceuticals melanoma with BRAF V600E or V600K mutations Trametinib Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Dabrafenib Novartis...

(uncommon/rare). Vemurafenib PO BRAF kinase inhibitor. BRAF kinase mutation V600E-positive Metastatic melanoma. Skin reactions, secondary malignancies (mostly...

IgVH status miR-15a, miR-195, miR-221, miR-155, miR-23b Melanoma with BRAF V600E miR-193a, miR-338, miR-565 Lymphoma Diffuse Large B Cell Lymphoma has-miR-128...

single amino acid: Val 600 into Glu, and this aberrant gene product (BRAF-V600E) can be visualized by immunohistochemistry for clinical molecular diagnostics...

treatment of adults with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. It is also indicated...

contrast, growth factors such as IGF-1 and TGF-β (which is induced by the BRAF-V600E oncogene) suppress NIS gene expression, not letting NIS localize in the...