• Thumbnail for Von Willebrand factor
    Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient...
    17 KB (2,121 words) - 09:32, 20 August 2024
  • Thumbnail for Von Willebrand disease
    conditions. It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion...
    48 KB (5,933 words) - 10:45, 26 September 2024
  • Thumbnail for ADAMTS13
    13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large...
    12 KB (1,420 words) - 09:40, 14 January 2024
  • made major contributions to hematology. Von Willebrand disease and von Willebrand factor are named after him. He also researched metabolism, obesity and...
    26 KB (2,665 words) - 12:55, 6 August 2024
  • Thumbnail for Factor VIII
    from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX...
    17 KB (2,001 words) - 15:23, 28 August 2024
  • Von Willebrand factor type D domain (vWD) is an evolutionarily-conserved protein domain found in, among others, the von Willebrand factor (vWF). vWF is...
    4 KB (561 words) - 14:41, 14 May 2021
  • Thumbnail for ABO blood group system
    on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels"...
    59 KB (5,995 words) - 07:38, 8 October 2024
  • Thumbnail for Heyde's syndrome
    by cleavage of Von Willebrand factor (vWF) due to high shear stress forces from aortic valvular stenosis. This results in Von Willebrand disease type IIA...
    24 KB (2,582 words) - 08:04, 20 July 2024
  • Thumbnail for Von Willebrand factor type A domain
    The von Willebrand factor type A (vWA) domain is a protein domain named after its occurrence in von Willebrand factor (vWF), a large multimeric glycoprotein...
    8 KB (791 words) - 11:13, 28 March 2024
  • Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins...
    5 KB (570 words) - 01:53, 31 December 2020
  • Thumbnail for Thrombotic thrombocytopenic purpura
    ADAMTS13. This results in decreased break down of large multimers of von Willebrand factor (vWF) into smaller units. Less commonly TTP is inherited, known...
    49 KB (5,038 words) - 20:12, 15 October 2024
  • Thumbnail for Von willebrand factor a domain containing 7
    Von Willebrand factor A domain containing 7 is a protein that in humans is encoded by the VWA7 gene. See articles on Von Willebrand factor and on Von...
    872 bytes (147 words) - 11:21, 30 September 2023
  • Thumbnail for Coagulation
    glycoprotein IIb/IIIa) to extracellular matrix proteins (e.g. von Willebrand factor) on cell membranes of damaged endothelial cells and exposed collagen...
    64 KB (6,553 words) - 17:35, 26 October 2024
  • Thumbnail for Haemophilia
    forming against a clotting factor. Other types include haemophilia C, which occurs due to low levels of factor XI, Von Willebrand disease, which occurs due...
    61 KB (6,747 words) - 04:54, 11 October 2024
  • Willebrand or Willebrands may refer to: Von Willebrand disease, a hereditary coagulation abnormality disease Von Willebrand factor, a blood glycoprotein...
    417 bytes (79 words) - 01:03, 9 March 2013
  • heart. They manufacture, store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation...
    9 KB (1,123 words) - 11:27, 9 October 2024
  • Thumbnail for Bernard–Soulier syndrome
    the glycoprotein Ib-IX-V complex (GPIb-IX-V), the receptor for von Willebrand factor. The incidence of BSS is estimated to be less than 1 case per million...
    9 KB (867 words) - 16:56, 16 July 2024
  • Thumbnail for Thrombophilia
    group is associated with reduced levels of von Willebrand factor — because of increased clearance — and factor VIII, which is related to thrombotic risk...
    47 KB (5,585 words) - 01:20, 24 September 2024
  • Thumbnail for Ristocetin
    Through an unknown mechanism, the antibiotic ristocetin causes von Willebrand factor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin...
    6 KB (412 words) - 20:32, 5 December 2023
  • platelet function. It measures platelet aggregation with the help of von Willebrand factor (vWF) and exogenous antibiotic ristocetin added in a graded fashion...
    4 KB (469 words) - 10:26, 7 November 2023
  • secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor, which initiates the maintenance of hemostasis after injury. These...
    18 KB (2,303 words) - 11:03, 27 April 2024
  • Thumbnail for Scottish Terrier
    the dog should not be bred. This disease is caused by a lack of von Willebrand factor which plays a role in the clotting process of blood. This can cause...
    39 KB (4,452 words) - 01:39, 18 September 2024
  • decreased release of the endothelium-derived relaxing factor and increased the release of von Willebrand factor (vWF), leading to general activation of the coagulation...
    33 KB (3,744 words) - 07:18, 5 September 2024
  • Thumbnail for Haemophilia A
    intravenous plasma concentrate factor VIII or efanesoctocog alfa, a von Willebrand factor (VWF) independent, recombinant DNA-derived Factor VIII (FVIII) concentrate...
    27 KB (2,867 words) - 17:50, 24 October 2024
  • Thumbnail for Vasopressin
    Günther G, Rosenthal W, Vischer UM (July 2000). "Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP"...
    45 KB (4,138 words) - 15:27, 16 September 2024
  • Thumbnail for Osteoprotegerin
    ligands include syndecan-1, glycosaminoglycans, von Willebrand factor, and factor VIII-von Willebrand factor complex. OPG has been identified as having a...
    30 KB (3,687 words) - 20:28, 17 May 2024
  • vWF-cleaving protease, VWF-CP, vWF-degrading protease, Upshaw factor, von Willebrand factor cleaving protease, ADAMTS13 peptidase) is an enzyme. This enzyme...
    2 KB (177 words) - 23:22, 7 October 2023
  • critical step in platelet adhesion, by facilitating binding to von Willebrand factor (VWF) on damaged sub-endothelium under conditions of high fluid...
    14 KB (1,648 words) - 22:47, 2 December 2023
  • on platelets. It is a transmembrane receptor for fibrinogen and von Willebrand factor, and aids platelet activation. The complex is formed via calcium-dependent...
    5 KB (500 words) - 06:24, 21 December 2023
  • Thumbnail for Upshaw–Schulman syndrome
    the ADAMTS13 protease resulting in the persistence of ultra large von Willebrand factor multimers (ULvWF), causing episodes of acute thrombotic microangiopathy...
    35 KB (3,487 words) - 19:17, 15 October 2024