A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic...

Calpain-6 (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene. Calpains are a ubiquitous, well-conserved family of calcium-dependent...

Calpain-2 (EC 3.4.22.53, calcium-activated neutral protease II, m-calpain, milli-calpain) is an intracellular heterodimeric calcium-activated cysteine...

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases...

Calpain-3 is a protein that in humans is encoded by the CAPN3 gene. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular...

Calpain-1 (EC 3.4.22.52, mu-calpain, calcium-activated neutral protease I) is an enzyme. This enzyme catalyses the following chemical reaction Broad endopeptidase...

Calpain-1 catalytic subunit (CANP 1) is a protein that in humans is encoded by the CAPN1 gene. The calpains, calcium-activated neutral proteases, are...

Calpain-8 is a protein in humans that is encoded by the CAPN8 gene. GRCh38: Ensembl release 89: ENSG00000203697 – Ensembl, May 2017 GRCm38: Ensembl release...

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene. Calpains are calcium-dependent cysteine proteases involved in signal transduction in...

Calpain small subunit 1 (CSS1) is a protein that in humans is encoded by the CAPNS1 gene. Calpains are a ubiquitous, well-conserved family of calcium-dependent...

dysregulation plays a role. Calpain 3 is unique from other calpain proteases in that it is relatively specific to muscle. Calpain 3 is both a protease and...

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene. The calpains, calcium-activated neutral proteases, are nonlysosomal...

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases...

including: Z line region: telethonin and alpha-actinin I band region: calpain-3 and obscurin M line region: myosin-binding protein C, calmodulin 1, CAPN3...

cell is calpain, a Ca2+-dependent non-lysosomal protease. About 15 minutes to half an hour after the onset of injury, a process called calpain-mediated...

reactions. The enzymes involved are proteinases (cathepsins – B, D, H & L, and calpains) and exopeptidases (peptidase and aminopeptidase). These enzymes cause...

is that the calcium-dependent protease calpain is involved: it has been shown that the inhibition of calpain leads to the inhibition of focal adhesion-ECM...

peptide for protein degradation. This may be mediated via the proteasome or calpain. Rogers S, Wells R, Rechsteiner M (1986). "Amino acid sequences common...

Chishti A, Bi X, Baudry M (November 2013). "Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated...

abnormalities: Bernard–Soulier syndrome, velocardiofacial syndrome Caused by calpain defect: Montreal platelet syndrome Caused by alpha granules defect: gray...

an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains...

activity, which also can cause apoptosis via a calcium binding protease calpain. The intrinsic pathway is also known as the mitochondrial pathway. Mitochondria...

eventually disintegrate. The disintegration is dependent on ubiquitin and calpain proteases (caused by the influx of calcium ion), suggesting that axonal...

H. A. (2008). Effect of two dietary concentrate levels on tenderness, calpain, and calpastatin activities, and cacass merit in Waguli and Brahman steers...

is a protease inhibitor that also acts as an inhibitor of calpain Melanostatin (prolyl-leucyl-glycinamide) is a peptide hormone produced...

axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytoskeleton. Spectrin cleavage causes the membrane to...

the United States, in descending order, are those due to mutation of 1) calpain, 2) dysferlin, 3) collagen VI, 4) sarcoglycans, 5) anoctamin 5, and 6)...

enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the...

Ashraf MZ (February 2014). "Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype". Blood. 123 (8):...

lysis. Maitotoxin can indirectly activate calcium-binding proteases calpain-1 and calpain-2, contributing to necrosis. The toxicity of maitotoxin in mice...