• Glucagon-like peptide-1 (GLP-1) receptor agonists, also known as GLP-1 analogs, GLP-1DAs or incretin mimetics, are a class of anorectic drugs that reduce...
    48 KB (5,006 words) - 23:51, 7 November 2024
  • Thumbnail for Glucagon-like peptide-1
    Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from the tissue-specific posttranslational processing of the proglucagon...
    29 KB (3,615 words) - 19:03, 2 November 2024
  • Thumbnail for Glucagon-like peptide-1 receptor
    that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. In the TMD domain there is a fulcrum...
    33 KB (4,119 words) - 09:50, 28 October 2024
  • GLP may refer to: G9a-like protein Glucagon-like peptide-1 (GLP-1) GLP-1 receptor agonists, which are sometimes referred to as "GLPs" Glucagon-like peptide-2...
    789 bytes (122 words) - 20:28, 14 August 2024
  • GLP1 poly-agonist peptides (category GLP-1 receptor agonists)
    including the glucagon-like peptide-1 (GLP-1) receptor. These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity...
    8 KB (899 words) - 10:09, 6 August 2024
  • Thumbnail for Tirzepatide
    Tirzepatide (category GLP-1 receptor agonists)
    weight loss. Tirzepatide is a gastric inhibitory polypeptide receptor and GLP-1 receptor agonist. The most common side effects include nausea, vomiting...
    44 KB (3,512 words) - 16:20, 8 November 2024
  • Thumbnail for Semaglutide
    Semaglutide (category GLP-1 receptor agonists)
    management. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be administered by subcutaneous injection...
    72 KB (6,068 words) - 21:55, 6 November 2024
  • peptide-1 (GLP-1), a hormone that stimulates the production of insulin but has a short half-life of minutes in the body.[third-party source needed] GLP-1 had...
    17 KB (1,919 words) - 21:41, 3 October 2024
  • Thumbnail for Incretin
    islets of Langerhans by a blood-glucose–dependent mechanism. Some incretins (GLP-1) also inhibit glucagon release from the alpha cells of the islets of Langerhans...
    7 KB (885 words) - 09:29, 30 September 2024
  • Survodutide (category GLP-1 receptor agonists)
    experimental peptide that works as a dual glucagon/GLP-1 receptor agonist. Unlike other dual GLP-1/glucagon dual agonists, it is a glucagon analog rather...
    7 KB (207 words) - 18:46, 16 June 2024
  • MariTide (category GLP-1 receptor agonists)
    developed by Amgen for the treatment of obesity. It is an agonist of the GLP-1 receptor (GLP-1R) and an antagonist of the glucose-dependent insulinotropic polypeptide...
    5 KB (293 words) - 22:07, 2 October 2024
  • VK2735 (category GLP-1 receptor agonists)
    VK2735 is a dual agonist of the GLP-1 receptor and GIP receptor, with a similar mechanism of action as tirzepatide, which acts on the same receptors....
    2 KB (175 words) - 17:16, 22 August 2024
  • Thumbnail for Anti-obesity medication
    earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss. The medications liraglutide...
    53 KB (4,991 words) - 18:16, 16 September 2024
  • peptide-1 (GLP-1). GLP-2 is produced by the intestinal endocrine L cell and by various neurons in the central nervous system. Intestinal GLP-2 is co-secreted...
    2 KB (258 words) - 20:23, 20 December 2023
  • Thumbnail for Dulaglutide
    Dulaglutide (category GLP-1 receptor agonists)
    glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. GLP-1 is a hormone that...
    16 KB (1,542 words) - 20:53, 21 September 2024
  • decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide...
    51 KB (5,305 words) - 19:29, 4 November 2024
  • Cagrilintide/semaglutide (category GLP-1 receptor agonists)
    cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is injected once weekly and is being tested in type 2 diabetes...
    6 KB (422 words) - 13:41, 6 August 2024
  • Thumbnail for Retatrutide
    Retatrutide (category GLP-1 receptor agonists)
    Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors). It has been shown to achieve a more than 17.5%...
    4 KB (328 words) - 05:24, 6 August 2024
  • Thumbnail for Orforglipron
    Orforglipron (category GLP-1 receptor agonists)
    glucagon-like peptide-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It is easier to produce than current peptide GLP-1 agonists and...
    3 KB (184 words) - 13:53, 14 June 2024
  • contributed to the identification of GLP-1 as a satiety hormone, which has played a key role in the development of GLP-1 drugs for the treatment of obesity...
    18 KB (1,761 words) - 13:31, 14 October 2024
  • glucagon-like peptide-1 (GLP-1), a hormone generated by the gut that triggers the release of insulin. The amino acid sequence of GLP-1 was similar to a gastric...
    11 KB (1,242 words) - 22:32, 6 November 2024
  • role of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2). Habener received credit for the work on hormones when...
    3 KB (259 words) - 22:06, 6 November 2024
  • anonymous group therapy. In 2024, Hims announced it would add compounded GLP-1 injections to its product portfolio, giving customers a way to access weight...
    9 KB (704 words) - 02:37, 21 October 2024
  • Thumbnail for Metabolic dysfunction–associated steatotic liver disease
    or resolve severe cases. There is some evidence for SGLT-2 inhibitors, GLP-1 agonists, pioglitazone, and vitamin E in the treatment of MASLD. In March...
    137 KB (15,203 words) - 03:09, 15 October 2024
  • Thumbnail for Liraglutide
    Liraglutide (category GLP-1 receptor agonists)
    injection under the skin. Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics. It works by...
    32 KB (2,752 words) - 00:10, 2 November 2024
  • Thumbnail for Gastric inhibitory polypeptide
    to stimulate insulin secretion. GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins, which stimulate...
    9 KB (1,052 words) - 16:12, 2 May 2024
  • systematic review and network meta-analysis comparing SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors demonstrated that use of SGLT2 inhibitors...
    44 KB (4,537 words) - 07:53, 5 November 2024
  • (born 1 August 1945) is a Danish physician and physiologist. He is known for discovering and describing the hormone glucagon-like peptide-1 (GLP-1), a hormone...
    4 KB (337 words) - 04:57, 12 August 2024
  • Thumbnail for GLP (company)
    GLP (formerly Global Logistic Properties) is a global owner, developer and operator of logistics real estate, digital infrastructure and renewable energy...
    13 KB (1,243 words) - 22:34, 5 November 2024
  • Thumbnail for Vildagliptin
    class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta...
    8 KB (688 words) - 06:01, 17 June 2024