Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of...
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Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is...
19 KB (2,210 words) - 12:51, 22 December 2023
diminished in patients with insulin-resistance. Hepatocyte nuclear factors Hepatocyte nuclear factor 4A Chartier FL, Bossu JP, Laudet V, Fruchart JC,...
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Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is...
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for example, hepatocyte nuclear factors). Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts...
75 KB (8,023 words) - 07:06, 3 June 2024
HNF1B (redirect from Transcription factor 2)
B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. HNF1B encodes hepatocyte nuclear factor...
9 KB (1,254 words) - 20:30, 30 May 2024
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
58 KB (6,927 words) - 03:33, 17 June 2024
FOXA2 (category Forkhead transcription factors)
Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development...
12 KB (1,552 words) - 05:23, 3 June 2024
HNF1A (redirect from Transcription factor 1)
HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many...
23 KB (2,738 words) - 04:41, 8 March 2024
MeSH D12.776.260.950.249.750 – hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 – hepatocyte nuclear factor 3-gamma The list continues at...
27 KB (972 words) - 19:42, 9 December 2023
complex combinations of causes involving multiple genes and environmental factors, each forms of MODY are caused by changes to a single gene (monogenic)...
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MeSH D12.776.660.352.500.500 – hepatocyte nuclear factor 1-alpha MeSH D12.776.660.352.500.750 – hepatocyte nuclear factor 1-beta MeSH D12.776.660.650.875...
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MST1 (redirect from Hepatocyte growth factor-like protein)
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded...
7 KB (901 words) - 22:17, 3 March 2023
Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The...
74 KB (6,675 words) - 18:09, 20 June 2024
transcription factor MeSH D12.776.930.316.750.770 – nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 – hepatocyte nuclear factor 1-alpha...
30 KB (1,091 words) - 16:46, 9 February 2024
mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha (HNF4A) binding to a DR1 like cis element which then stimulate...
57 KB (4,584 words) - 00:45, 31 May 2024
PMID 22912808. Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in part through secreted...
23 KB (2,452 words) - 15:25, 22 March 2024
FOXA3 (category Forkhead transcription factors)
a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts...
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"Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells". Mol. Endocrinol...
11 KB (1,278 words) - 04:12, 27 May 2024
FOXA1 (category Forkhead transcription factors)
also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a pioneer factor, a transcription...
7 KB (802 words) - 18:08, 19 April 2024
Renal cysts and diabetes syndrome (category Transcription factor deficiencies)
"Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor-1beta". Nephrol. Dial. Transplant. 19 (11): 2703–8. doi:10.1093/ndt/gfh348...
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communication between β-catenin (inside the hepatocyte) and the growth factors EGFR and HGFR or c-Met (outside the hepatocyte). The presence of these two proteins...
22 KB (2,472 words) - 03:27, 22 June 2024
2016-04-13. Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional...
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enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Mutations of the PCBD1 gene cause pterin-4 alpha-carbinolamine...
10 KB (1,069 words) - 12:00, 15 January 2024
6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin 15 PI4K2A: phosphatidylinositol...
28 KB (1,967 words) - 02:02, 11 April 2024
chromosome 12. This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α controls function...
3 KB (296 words) - 20:16, 1 December 2023
Wound healing (section Factors affecting wound healing)
cytokines and growth factors. Growth factors stimulate cells to speed their rate of division. Platelets release other proinflammatory factors like serotonin...
104 KB (11,855 words) - 18:42, 10 July 2024
FOX proteins (redirect from Forkhead transcription factors)
based on sequence conservation. FOXA1, FOXA2, FOXA3 (See also Hepatocyte nuclear factors.) FOXB1, FOXB2 FOXC1 (associated with glaucoma), FOXC2 (varicose...
8 KB (874 words) - 23:04, 18 August 2023
inhibits gluconeogenesis by inhibiting transcription factors including hepatocyte nuclear factor 4 (HNF4) and CREB regulated transcription coactivator...
65 KB (7,147 words) - 05:41, 24 June 2024
necrosis factor receptor members such as TRAF6, which results in the release of nuclear factor κB (NF-κB) transcription activator. NF-κB regulates nuclear gene...
23 KB (2,756 words) - 04:47, 10 July 2024