INK4 is a family of cyclin-dependent kinase inhibitors (CKIs). The members of this family (p16INK4a, p15INK4b, p18INK4c, p19INK4d) are inhibitors of CDK4...

two primary CKI families exist: the INK4 family (p16, p15, p18, p19) and the CIP/KIP family  (p21, p27, p57). The INK4 family proteins specifically bind...

In 2009, Sharpless and his team were the first to discover altered human INK4/ARF expression as the mechanism for the 9p21.3 genetic risk allele of atherosclerosis...

many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors...

isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor suppressor protein...

008. PMC 4536333. PMID 25565328. Xian, T.; Azpurua, J. (27 January 2015). "INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional...

2005, ISBN 978-0-19-926472-8, Section 5.3 Roussel MF (September 1999). "The INK4 family of cell cycle inhibitors in cancer". Oncogene. 18 (38): 5311–5317...

June 1994). "Blue Tiger". Variety. Retrieved 16 June 2020. "First Look, Oz ink4-pic pact". Variety. Retrieved October 19, 2024. Mes, Tom (2024) [first published...

original on November 21, 2007. Retrieved August 29, 2011. "First Look, Oz ink4-pic pact". Variety. Retrieved October 19, 2024. Mes, Tom (2024) [first published...

controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to...

protein/Kinase inhibitory protein) family is one of two families (CIP/KIP and INK4) of mammalian cyclin dependent kinase (CDK) inhibitors (CKIs) involved in...

regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors". Molecular Cancer Research. 7 (4): 570–80. doi:10...

Additionally, CDK4/6 and CDK2 are also inactive because CDK4/6 are bound by INK4 family members (e.g., p16), limiting kinase activity. Meanwhile, CDK2 complexes...

deletion, or downregulation of the inhibitors. Homozygous deletions in p16, an INK4-family inhibitor of Cdk4, have been found in over 50% of gliomas, and mutations...

complexes are very similar to Drosophila. Polycomb Bmi1 is known to regulate ink4 locus (p16Ink4a, p19Arf). Regulation of Polycomb-group proteins at bivalent...

centlein CDKN2BAS: CDKN2B antisense RNA 1 or antisense non-coding RNA in the INK4 locus (ANRIL) COL5A1: collagen, type V, alpha 1 DDX31: DEAD box polypeptide...

S2CID 37848897. Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ (May 1995). "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent...

which the arteries become hard. It has been proposed that cANRIL can modify INK4/ARF expression, which, in turn, increases risk for atherosclerosis. Further...

(April 2007). "Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL...

cyclin-dependent kinase inhibitor protein (CKIs) like the INK4 family (e.g. p14, p15, p16, p18). INK4 proteins are activated in response to hyperproliferative...

and the G1-S transition are suppressed by cell cycle inhibitors including Ink4 and Cip/Kip family proteins. As a result, Rb is hypophosphorylated and inhibits...

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome...

cyclin D acts as a mitogenic signal sensor. Cdk inhibitors (CKI), such as the Ink4 proteins and p21, help to prevent improper cyclin-cdk activity. Active cyclin...

, Marazita, M.C., Carcagno, A.L., Sirkin, P.F., and Ogara, M.F. (2007). INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions...

by the CDKN2C gene. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown...

the expression of INK4/ARF tumor suppressor genes through a mechanism involving the epigenetic modification of chromatin at the INK4/ARF locus. In addition...

Sharpless, NE (2010). "Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk". PLOS...

cyclin-dependent kinase inhibitor protein, helps control CDK activity in G1. Also, the INK4 proteins help stop the G1-CDK activity when they encounter anti-proliferative...

Z (Jun 2000). "A minimum folding unit in the ankyrin repeat protein p16(INK4)". J Mol Biol. 299 (4): 1121–32. doi:10.1006/jmbi.2000.3803. PMID 10843863...

Yuan C, Selby TL, Li J, Byeon IJ, Tsai MD (June 2000). "Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure...