Interferons (IFNs, /ˌɪntərˈfɪərɒn/ IN-tər-FEER-on) are a group of signaling proteins made and released by host cells in response to the presence of several...
62 KB (7,065 words) - 05:17, 28 June 2024
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian...
30 KB (2,727 words) - 19:16, 6 April 2024
Pegylated interferon (PEG-IFN) is a class of medication that includes three different drugs as of 2012: Pegylated interferon-alpha-2a Pegylated interferon-alpha-2b...
2 KB (185 words) - 07:35, 11 September 2023
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon...
56 KB (6,476 words) - 11:26, 29 July 2024
Interferon alfa (INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the...
7 KB (654 words) - 21:00, 23 April 2024
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by...
23 KB (2,748 words) - 13:53, 21 January 2024
An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. Interferons bind to receptors on the surface...
13 KB (1,530 words) - 20:52, 19 April 2024
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses...
24 KB (2,932 words) - 03:26, 14 June 2024
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon...
24 KB (2,894 words) - 01:36, 26 August 2023
Interferon tau (IFNτ, IFNT) is a Type I interferon made of a single chain of amino acids. IFN-τ was first discovered in ruminants as the signal for the...
15 KB (1,827 words) - 13:36, 23 May 2024
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and...
10 KB (793 words) - 20:09, 20 December 2023
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory...
10 KB (1,098 words) - 23:10, 30 March 2024
Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene. IFITM1 is a member of the IFITM family (Interferon-induced...
3 KB (394 words) - 23:45, 2 December 2023
Interferon alpha-n3 (Alferon-N) is a medication consisting of purified natural human interferon alpha proteins used for the treatment of genital warts...
3 KB (28 words) - 01:47, 2 December 2023
Interferon-γ release assays (IGRA) are medical tests used in the diagnosis of some infectious diseases, especially tuberculosis. Interferon-γ (IFN-γ)...
4 KB (583 words) - 20:36, 8 July 2024
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS)...
13 KB (1,292 words) - 19:17, 6 April 2024
signaling as immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally...
35 KB (3,892 words) - 12:38, 3 August 2024
Plasmacytoid dendritic cell (redirect from Interferon Producing Cells)
type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. They circulate in the blood and...
14 KB (1,833 words) - 05:36, 27 December 2023
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human...
24 KB (2,617 words) - 19:43, 7 August 2022
ISG15 (redirect from Interferon-stimulated gene 15)
Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon...
22 KB (2,575 words) - 06:16, 1 January 2024
Peginterferon alfa-2a (redirect from Pegylated interferon-alpha-2a)
Pegylated interferon alfa-2a, sold under the brand name Pegasys among others, is medication used to treat hepatitis C and hepatitis B. For hepatitis C...
11 KB (892 words) - 19:27, 17 March 2024
International Cytokine & Interferon Society (ICIS) is a non-profit organization composed of researchers of cytokines, interferons and chemokine cell biology...
2 KB (216 words) - 11:27, 29 July 2024
The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon...
8 KB (870 words) - 23:14, 28 May 2024
of interferon gamma and TNF.[citation needed] CD4+ T-helper cells may be differentiated into two main categories: TH1 cells which produce interferon gamma...
14 KB (1,381 words) - 03:19, 4 May 2024
Interferon alfacon-1 is a recombinant synthetic type I interferon used for the treatment of hairy cell leukemia, malignant melanoma and AIDS-related Kaposi's...
2 KB (30 words) - 16:41, 12 November 2023
Natalizumab and interferon beta-1a (Rebif) may reduce relapses compared to both placebo and interferon beta-1a (Avonex) while Interferon beta-1b (Betaseron)...
170 KB (18,093 words) - 05:53, 12 August 2024
Recombinant feline interferon omega (RFeIFN-ω), sold under the brand name Virbagen Omega among others, is a recombinant version of a cat interferon alpha. It is...
6 KB (454 words) - 05:59, 3 December 2023
In molecular biology, the interferon-inducible GTPase (IIGP) family of proteins is thought to play a role in intracellular defence. IIGP is predominantly...
1 KB (120 words) - 04:20, 21 December 2020
Diagnosis of tuberculosis (redirect from Interferon gamma release assays)
where TB prevalence is high. These have been reviewed in detail. Interferon-γ (interferon-gamma) release assays (IGRAs) are 21st century tests for tuberculosis...
46 KB (5,284 words) - 18:48, 27 June 2024
It binds to the type I interferon receptor, blocking the activity of type I interferons such as interferon-α and interferon-β.[medical citation needed]...
12 KB (826 words) - 05:37, 26 March 2024