Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and...
26 KB (3,273 words) - 08:48, 14 October 2024
cytokines that mediate immune responses. Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation...
45 KB (4,194 words) - 12:36, 2 May 2024
until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. IL-1α is also...
22 KB (2,679 words) - 06:27, 13 September 2024
inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory...
12 KB (1,323 words) - 14:55, 7 September 2024
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
21 KB (2,398 words) - 19:18, 2 October 2024
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections...
50 KB (6,093 words) - 20:45, 19 November 2024
antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Common side...
15 KB (1,264 words) - 06:00, 18 July 2024
to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor...
10 KB (1,262 words) - 03:39, 18 February 2024
Caspase (section Pyroptosis by caspase-1)
with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1). At the time, ICE was the only known caspase...
28 KB (3,115 words) - 02:10, 8 November 2024
osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial...
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the signaling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by...
11 KB (1,399 words) - 09:00, 2 November 2024
with several inflammatory markers, including interleukin 1 beta, interleukin 4, interleukin 6, interleukin 10, tumor necrosis factor TNFα-R2, C-reactive...
5 KB (527 words) - 06:54, 15 August 2023
Sulfonylurea (section Interleukin-1 β inhibitors)
Sulfonylureas are also used experimentally to inhibit release of interleukin 1 beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed...
25 KB (2,738 words) - 14:08, 9 October 2024
pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion"...
24 KB (2,881 words) - 19:11, 20 November 2024
IL1RL2 (redirect from Interleukin 1 receptor-like 2)
1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type...
4 KB (603 words) - 21:06, 3 March 2023
related to interleukin 1-beta. Both families have the same beta trefoil fold consisting of 12-stranded beta-sheet structure, with the beta-sheets are...
25 KB (3,124 words) - 21:38, 18 August 2024
experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells". European Journal of Clinical...
41 KB (3,770 words) - 03:37, 25 November 2024
lethal factor was presumed to cause macrophages to make TNF-alpha and interleukin 1 beta (IL1B). TNF-alpha is a cytokine whose primary role is to regulate...
98 KB (10,351 words) - 20:34, 22 November 2024
regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha". The Journal of Biological Chemistry...
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Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12...
10 KB (1,383 words) - 03:56, 13 August 2023
Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1 and beta 2 subunits. Chua AO, Chizzonite R, Desai...
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Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name...
11 KB (1,323 words) - 16:26, 21 August 2024
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
14 KB (1,578 words) - 23:52, 11 October 2024
this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein...
12 KB (1,190 words) - 21:31, 19 October 2024
activities of interleukin 1(alpha) and interleukin 1(beta). Therefore, the pathophysiologic immune and inflammatory responses are nullified. Interleukin 1 receptor...
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mostly of gases and liquids other than hydrogen and helium Caspase 1 or Interleukin-1 beta Converting Enzyme ICE table (initial, change, equilibrium), a table...
8 KB (950 words) - 11:53, 26 October 2024
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
40 KB (4,619 words) - 06:54, 7 November 2024
daily colchicine regimen has been successful. Canakinumab, an anti-interleukin-1-beta monoclonal antibody, has likewise been shown to be effective in controlling...
25 KB (2,650 words) - 22:26, 13 November 2024
rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis...
14 KB (1,640 words) - 21:27, 6 September 2024
macrophages, and mast cells. The inflammatory mediators are: interleukin 1 beta, interleukin 6, tumor necrosis factor alpha (TNF alpha), MMP1, MMP2, MMP9...
36 KB (3,912 words) - 09:57, 17 November 2024