Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is a humanized monoclonal...

various transplant drugs, which are meant to weaken the immune system. Natalizumab (Tysabri) was approved in 2004 by the FDA for the treatment of multiple...

antipsychotics, especially in elderly patients with dementia. As of 2006[update], natalizumab (marketed as Tysabri) received a boxed warning on its packaging due to...

confidence that natalizumab, cladribine, or alemtuzumab are decreasing relapses over a period of two years for people with RRMS. Natalizumab and interferon...

beta 1a and natalizumab: Dangerous but effective. Linked with PML, but is remarkable that Natalizumab alone is also linked with it. Natalizumab and fingolimod...

1146/annurev.immunol.19.1.163. PMID 11244034. Doggrell SA (June 2003). "Is natalizumab a breakthrough in the treatment of multiple sclerosis?". Expert Opinion...

treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin antagonists like ustekinumab. Prior to the development...

focused on physiological and neuropathic pain. Previously named Antegren, natalizumab is a drug co-marketed by Biogen Idec and Élan as "Tysabri". Tysabri is...

system disorders; and rare reports of cardiac failure.[citation needed] Natalizumab is an anti-integrin monoclonal antibody that has shown utility as induction...

reported in patients treated with the drug. The boxed warning for the drug natalizumab (Tysabri) includes a statement that Human polyomavirus 2 resulted in...

helps white blood cells enter the gut, reducing inflammation. Unlike natalizumab, it does not carry a risk of the serious brain infection PML. While vedolizumab...

2023 adalimumab-aaty/Yuflyma adalimumab/Humira August 2023 natalizumab-sztn/Tyruko natalizumab/Tysabri September 2023 tocilizumab-bavi/Tofidence tocilizumab/Actemra...

against the therapeutic antibody) infliximab -zumab humanized antibody natalizumab, bevacizumab -anib Angiogenesis inhibitors pazopanib, vandetanib -ciclib...

hepatitis. Muzolimine 1987 France, Germany, European Union Polyneuropathy. Natalizumab (Tysabri) 2005–2006 US Voluntarily withdrawn from US market because of...

L04AF08 Ritlecitinib L04AG01 Muromonab-CD3 L04AG02 Efalizumab L04AG03 Natalizumab L04AG04 Belimumab L04AG05 Vedolizumab L04AG06 Alemtuzumab L04AG07 Begelomab...

have been reported, which has also been reported in patients taking natalizumab (Tysabri), an approved multiple sclerosis drug. Fingolimod has also been...

produce IL-1β. Treatment of multiple sclerosis with glatiramer acetate or natalizumab has also been shown to reduce the presence of IL-1β or its receptor....

Ruplizumab BLyS Belimumab CAT Bertilimumab Lerdelimumab Metelimumab Integrin Natalizumab Vedolizumab Interleukin-6 receptor Tocilizumab LFA-1 Odulimomab IL-2...

developing progressive multifocal leukoencephalopathy during treatment with natalizumab". Annals of Neurology. 77 (3): 447–457. doi:10.1002/ana.24345. PMID 25581547...

Merck KGaA 4 $1.93 billion Fingolimod Gilenya Novartis 5 $1.41 billion Natalizumab Tysabri Biogen Idec 6 $1.38 billion Interferon beta 1b Betaseron/Betaferon...

FDA include: interferons beta-1a and beta-1b; monoclonal antibodies: natalizumab, alemtuzumab, ocrelizumab, ofatumumab, and ublituximab; and immunomodulators:...

an autoimmune reaction has been to block the action of VLA-4 (as with natalizumab) so that pathogenic T-cells are unable to enter the brain and thus unable...

Lampalizumab† Letolizumab Ligelizumab† Lulizumab pegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab (+hyaluronidase) Omalizumab Ozoralizumab Pascolizumab Pateclizumab...

(dimethyl fumarate) Relapsing forms of multiple sclerosis 2013 2014 TYSABRI (natalizumab) Relapsing-remitting multiple sclerosis 2004 Re-introduced in 2006 2006...

stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab". Journal of Neurology. 255 (9): 1436–1438. doi:10.1007/s00415-008-0956-x...

emtansine mab chimeric CD37 Narnatumab mab human MST1R (aka RON) cancer Natalizumab Tysabri mab humanized integrin α4 Y multiple sclerosis, Crohn's disease...

Nasarel nasaruplase (INN) nasaruplase beta (INN) Nascobal Nasonex Natacyn natalizumab (INN) natamycin (INN) nateglinide (INN) nateplase (INN) Natrecor Naturetin...

research leading to the first approved monoclonal antibody therapy for MS, Natalizumab (Tysabri), and clarified the molecular basis for how EBV triggers MS...

GlaxoSmithKline 11/4/2015 subcutaneous humanized IL5 Severe asthma 125526 Link natalizumab Tysabri Biogen Idec 11/23/2004 intravenous humanized alpha-4 integrin...

immunosuppressants used to treat MS—such as interferon-β, fingolimod, natalizumab, and alemtuzumab—worsen NMO disease progression and should not be used...