An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue. This function...

resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in...

osteocytes are involved in the formation and mineralisation of bone; osteoclasts are involved in the resorption of bone tissue. Modified (flattened) osteoblasts...

activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by...

body. Osteoclasts are frequently classified and discussed separately from other MGCs which are more closely linked with disease. Non-osteoclast MGCs can...

Osteoclast stimulatory transmembrane protein is a protein that in humans is encoded by the OCSTAMP gene. GRCh38: Ensembl release 89: ENSG00000149635 –...

Chambers he developed the osteoclast lacunar bone resorption assay system. His work was the first to show that the human osteoclast shares specific surface...

New bone is deposited by osteoblast cells and resorbed or destroyed by osteoclast cells. This addition and subtraction of bone usually yields no net change...

mechanisms. Under normal circumstances, TRAP is highly expressed by osteoclasts, activated macrophages, neurons, and by the porcine endometrium during...

understood. It is postulated that osteoclasts are the cells responsible for the resorption of the root surface. Osteoclasts can break down bone, cartilage...

NF-κB ligand (RANKL)–induced osteoclast differentiation. Pepstatin A suppresses the formation of multinuclear osteoclasts dose-dependently. This inhibition...

dysplasias. The cause of the disease is understood to be malfunctioning osteoclasts and their inability to resorb bone. Although human osteopetrosis is a...

The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. They are a form of osteitis fibrosa...

increased tubular reabsorption of calcium and activation of osteoclast activity, respectively. Osteoclasts are a type of bone cell which cause bone resorption...

expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer...

factor kappa-Β ligand), which works by decreasing the development of osteoclasts, which are cells that break down bone. It was developed by the biotechnology...

of plasma B cells, T cells, dendritic cells (DCs), macrophages, and osteoclasts. Pattern Recognition Receptors (PRRs) can activate BLIMP-1, both as a...

during the differentiation of osteoclast precursor cells into mature osteoclasts, known as osteoclastogenesis. Mature osteoclasts then bind to bone through...

responsible for bone metabolism: osteoblasts (which secrete new bone), and osteoclasts (which break bone down). The structure of bones as well as adequate supply...

tumor can be subclassified. Osteosarcomas may exhibit multinucleated osteoclast-like giant cells. X-rays is the initial imaging of choice to diagnose...

bone. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). Malignancy in giant-cell tumor is uncommon and occurs in...

osteoblasts creating bone and osteoclasts destroying bone. Bisphosphonates inhibit the digestion of bone by encouraging osteoclasts to undergo apoptosis, or...

neutralize excessive existing acid. Hydrochloric acid is also used by osteoclasts alongside proteases for bone resorption. Being a strong acid, hydrochloric...

active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. Although osteoclasts are active during the natural formation...

cells exhibit these dynamic structures such as invasive cancer cells, osteoclasts, vascular smooth muscle cells, endothelial cells, and certain immune...

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene. Osteoclasts are multinucleated cells that...

with tumor metastasis to bones. Gallium is thought to interfere with osteoclast function, and the therapy may be effective when other treatments have...

alendronate have an increase in the numbers of osteoclasts and develop giant, more multinucleated osteoclasts; the significance of this development is unclear...

shown to stimulate osteoclast differentiation and function. Studies have found that blockade of the A1 Receptor suppresses the osteoclast function, leading...

secretion osteoclast differentiation regulation of tumor necrosis factor-mediated signaling pathway response to virus positive regulation of osteoclast differentiation...