Prenylation (also known as isoprenylation or lipidation) is the addition of hydrophobic molecules to a protein or a biomolecule. It is usually assumed...

transmembrane domain. One form of C-terminal modification is prenylation. During prenylation, a farnesyl- or geranylgeranyl-isoprenoid membrane anchor is...

of the protein. This prenylation of lipid chains to proteins facilitate their interaction with the cell membrane. The prenylation motif “CaaX box” is the...

pyrophosphate and geranylgeranyl pyrophosphate. Inhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated...

beta (IL-1β) in MKD, most likely mediated by defective protein prenylation. Prenylation refers to addition of hydrophobic isoprenoids to proteins, such...

as well as in modulating protein–protein interactions. In contrast to prenylation and myristoylation, palmitoylation is usually reversible (because the...

PMID 20962881. Magee T, Seabra MC (April 2005). "Fatty acylation and prenylation of proteins: what's hot in fat". Current Opinion in Cell Biology. 17...

lipid metabolism (sphingolipids, fatty acids), apoptosis, autophagy, and prenylation of proteins; the mode of action of oxysterols in these effects is still...

to its prenylation and palmitoylation (HRAS and NRAS) or the combination of prenylation and a polybasic sequence adjacent to the prenylation site (KRAS)...

some small proteins to the cell membrane. This phenomenon is known as prenylation, and is important for proper sub-cellular protein trafficking (see "lipid-anchored...

Geranylgeranylation is a form of prenylation, which is a post-translational modification of proteins that involves the attachment of one or two 20-carbon...

catalyzing the first step in ergot alkaloid biosynthesis, i.e., the prenylation of L-tryptophan. Further reactions, involving methyltransferase and oxygenase...

1002/14356007.a26_205. ISBN 978-3527306732. Fellermeier M, Zenk MH (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the...

into membranes via an N-terminal helix (rather than myristoylation or prenylation). These coat proteins are necessary but insufficient to direct or dock...

signaling pathway and activation of anti-viral cell mediated immunity. The prenylation inhibitor lonafarnib prevents hepatitis D viral particle assembly by...

the anticodon release on degradation the adenosine as a cytokinin. The prenylation of these adenines is carried out by tRNA-isopentenyltransferase. Auxin...

both help with the prenylation and transport of Rab proteins. Rab27 has been found to preferentially depend on REP-1 for prenylation, which could be the...

November 2003). "Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases". The Journal of Biological Chemistry. 278 (47):...

2020-06-27. Retrieved 2019-07-04. Fellermeier M, Zenk MH (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the...

give 2,3,4,6-tetrahydroxyisovalerophenone. This step is followed by prenylation with 1-bromo-3-methyl-2-butene to give humulone. As determined by INADEQUATE...

cytoplasmic side of the cell membrane via palmitoylation, myristoylation, or prenylation. On the exoplasmic face of the cell membrane, lipid anchored proteins...

migration in zebrafish is dependent on HMGCoA reductase activity and prenylation". Developmental Cell. 6 (2): 295–302. doi:10.1016/S1534-5807(04)00032-2...

sulfhydryl group allows cysteine to conjugate to other groups, e.g., in prenylation. Ubiquitin ligases transfer ubiquitin to its pendant, proteins, and caspases...

synthesize this pheromone as a natural insect repellent. Farnesol Nerolidol Prenylation Terpene HUELIN, F.E.; Murray, K.E. (18 June 1966). "α-Farnesene in the...

linkage Topaquinone (TPQ) formation Detyrosination Cysteine Palmitoylation Prenylation Aspartate Succinimide formation ADP-ribosylation Glutamate Carboxylation...

GGTase is “responsible for the largest number of individual protein prenylation events in the cell,” probably due to this ability to interact with many...

acylation), attachment of palmitate, a C16 saturated acid isoprenylation or prenylation, the addition of an isoprenoid group (e.g. farnesol and geranylgeraniol)...

inhibitors block the activity of the farnesyltransferase enzyme by inhibiting prenylation of the CAAX tail motif, which ultimately prevents Ras from binding to...

for GTP binding and hydrolysis. The C-terminal of RhoA is modified via prenylation, anchoring the GTPase into membranes, which is essential for its role...

the formation of the ergoline scaffold. This synthesis starts with the prenylation of L-tryptophan in an SN1 fashion with dimethylallyl diphosphate (DMAPP)...