small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily...
34 KB (4,040 words) - 14:34, 19 July 2024
SYNGAP1 (redirect from Synaptic Ras GTPase-activating protein 1)
Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1...
19 KB (2,243 words) - 05:13, 1 March 2024
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal...
14 KB (1,605 words) - 22:45, 27 March 2024
GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and...
16 KB (2,237 words) - 20:38, 22 July 2024
state, and such mutations in the small GTPase Ras are particularly common in some forms of cancer. In most GTPases, the specificity for the base guanine...
20 KB (2,306 words) - 18:17, 15 July 2024
diphosphate (GDP). The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases. A typical G-protein is active when bound...
4 KB (503 words) - 09:22, 21 October 2023
GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. Ras proteins are membrane-associated molecular switches that...
3 KB (304 words) - 16:29, 26 July 2023
encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases. The gene was so named because the Sos protein that it encoded...
7 KB (837 words) - 06:22, 8 August 2022
two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological...
17 KB (2,012 words) - 07:14, 14 August 2023
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families...
6 KB (291 words) - 12:53, 5 November 2021
Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. This gene encodes one of the DNA-unwinding enzymes...
9 KB (1,149 words) - 02:40, 16 July 2024
member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart...
1 KB (222 words) - 22:20, 3 March 2023
to treat non-small cell lung cancer. Adagrasib is an inhibitor of the RAS GTPase family. It is taken by mouth. It is being developed by Mirati Therapeutics...
12 KB (747 words) - 11:55, 19 July 2024
HRAS (redirect from GTPase HRas)
a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase...
10 KB (1,338 words) - 02:39, 13 June 2024
alternative splicing. M-Ras is a member of the small GTPase superfamily under the Ras family, which also includes Rap1, Rap2, R-Ras, and R-Ras2 (TC21). This...
21 KB (2,597 words) - 05:11, 26 February 2024
family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have...
25 KB (3,198 words) - 05:03, 22 June 2024
homology domain, also called the RasGEF domain, is the catalytic domain of many Ras GEFs, which activate Ras GTPases. The CDC25 domain comprises approximately...
18 KB (2,253 words) - 09:08, 21 October 2023
compartment (ERGIC, in mammals). Coat assembly is initiated when the cytosolic Ras GTPase Sar1 is activated by its guanine nucleotide exchange factor Sec12. Activated...
9 KB (1,077 words) - 22:23, 8 January 2024
Arginine finger (section Ras GTPases)
Arginine fingers are also present in Ras GTPases, where they help cleave GTP to turn Ras off. Ras is a GTPase which functions in signal transduction...
16 KB (1,644 words) - 09:30, 5 January 2024
in the protein K-Ras encoded by gene KRAS which is responsible for various forms of cancer. Sotorasib is an inhibitor of the RAS GTPase family. The most...
24 KB (1,773 words) - 11:30, 19 July 2024
signal threshold to activate T cells that have been previously activated. Ras GTPase activation is required for downstream effector functions of activated...
61 KB (7,557 words) - 03:50, 31 July 2024
Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene. This gene encodes a protein that contains the GAP-related...
4 KB (526 words) - 00:57, 11 April 2024
Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein...
8 KB (933 words) - 01:58, 14 August 2024
"Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity". J....
8 KB (950 words) - 22:19, 2 December 2023
MAPK/ERK pathway (redirect from Ras Raf Mek)
This allows a Ras protein (a Small GTPase) to swap a GDP molecule for a GTP molecule, flipping the "on/off switch" of the pathway. The Ras protein can then...
24 KB (3,068 words) - 07:21, 7 June 2024
Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene. This gene encodes a member of the GAP1 family of GTPase-activating...
4 KB (547 words) - 00:00, 4 March 2023
RAC1 (redirect from Ras-related C3 botulinum toxin substrate 1)
DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin...
29 KB (3,420 words) - 21:45, 4 April 2024
Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene. The protein encoded by this gene is member of the GAP1 family...
7 KB (862 words) - 01:00, 1 January 2024
G protein (section Small GTPases)
(γ) subunits. "Small" G proteins (20-25kDa) belong to the Ras superfamily of small GTPases. These proteins are homologous to the alpha (α) subunit found...
24 KB (2,754 words) - 20:56, 30 July 2024