Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene. SGK1 belongs to a...
35 KB (4,214 words) - 16:52, 11 August 2024
SGK (redirect from SGK1 (gene))
vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to...
5 KB (573 words) - 02:13, 6 May 2024
of KvLQT1 can also associate with SGK1, which stimulates the slow delayed potassium rectifier current. Since SGK1 requires structural integrity to stimulate...
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aldosterone, which induces SGK1. SGK1 influences both the WNK-SPAK-NCC and SGK1-ENaC signaling cascades. There are multiple SGK1 phosphorylation sites in...
31 KB (3,448 words) - 22:12, 9 October 2024
CARD11, FOXO1, GNA12, B2M (i.e. the gene for beta-2 microglobulin), and SGK1. Except for the t(14:18)(q32:q21.3) translocation and EZH2 mutations which...
67 KB (7,967 words) - 13:33, 14 October 2024
components of the ERK/MAPK signaling pathway that controls cell proliferation; SGK1 which codes for serine/threonine-protein kinase, a protein that regulates...
18 KB (2,173 words) - 18:04, 7 September 2023
Q96LD1 14669 SGF29 HGNC:25156 Q96ES7 14670 SGIP1 HGNC:25412 Q9BQI5 14671 SGK1 HGNC:10810 O00141 14672 SGK2 HGNC:13900 Q9HBY8 14673 SGK3 HGNC:10812 Q96BR1...
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phosphorylation at well-defined sites by AKT/SGK1 protein kinases. FOXO1 transcription factor can phosphorylate directly by AKT/SGK1 on three sites T24, S256 and S319...
28 KB (3,343 words) - 18:02, 7 November 2023
hypokalemia. Sgk1 kinase has also been reported to phosphorylate ROMK, resulting in an increase of channels on the apical surface of the distal tubule. Sgk1 is...
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channel or ENaC, Na+/K+ pump, serum and glucocorticoid induced kinase or SGK1) resulting in the reabsorption of sodium, and as a consequence an increase...
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through multiple mechanisms including miRNA regulation or activation of SGK1 kinase, which reacts to higher levels of NaCl in the body. It is suggested...
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2013). "Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1". Nature. 496 (7446): 513–517. Bibcode:2013Natur.496..513W. doi:10.1038/nature11984...
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FHHt. WNK1 activates the serum-and glucocorticoid-inducible protein kinase SGK1, leading to increased expression of the epithelial sodium channel (ENaC)...
14 KB (1,419 words) - 10:19, 26 October 2024
intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway...
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receptors in the heart and kidney to enhance expression of endogenous GILZ, SGK1, and CNKSR3; mediating the TNFα-induced decrease in endothelial nitric oxide...
22 KB (2,672 words) - 20:37, 3 December 2023
RPS6KC1 ; RPS6KL1 ; RSKR ; RYK ; SBK1 ; SBK2 ; SBK3 ; SCYL1 ; SCYL2 ; SCYL3 ; SGK1 ; SGK2 ; SGK223 ; SGK3 ; SIK1 ; SIK1B ; SIK2 ; SIK3 ; SLK ; SNRK ; SPEG ;...
17 KB (1,566 words) - 18:56, 22 September 2024
A, Jeyaraj S, Böhmer C, Lang F (May 2005). "The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2". Biochemical and Biophysical...
9 KB (1,181 words) - 00:04, 3 December 2023
"Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10). United States: 7676–83. doi:10.1074/jbc...
14 KB (1,775 words) - 06:46, 28 December 2023
KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3". Biochem. J. 384 (Pt 3): 477–88. doi:10.1042/BJ20041057. PMC 1134133...
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activity and/or interaction with substrates. NEDD4-2 phosphorylation by kinases SGK1 and AKT in response to insulin and aldosterone signaling results in its interaction...
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acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j...
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"Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi:10.1074/jbc.M107768200...
8 KB (1,022 words) - 01:26, 9 April 2022
Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem...
5 KB (574 words) - 22:56, 29 March 2024
intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway...
6 KB (785 words) - 22:47, 8 October 2024
component downstream from PI3K once active, and also in phosphorylation of SGK1, PKC and HDACs. Since mTORC2 plays a crucial role in metabolic regulation...
34 KB (3,791 words) - 19:30, 19 September 2024
necessary for stimulation of slow delayed potassium rectifier current by SGK1. The interaction of KCNE1 with an alpha helix in the S6 KvLQT1 domain contributes...
30 KB (3,995 words) - 10:11, 3 April 2024
"Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3". Biochem. Biophys. Res. Commun. 334 (3): 742–6. doi:10.1016/j.bbrc...
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(February 2010). "Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve". The Journal of Membrane Biology. 233 (1–3): 35–41...
94 KB (10,475 words) - 03:37, 24 March 2024