U.S. Route 45 (US 45) is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the...

U.S. Route 45 (US 45) in the state of Illinois is a major north–south U.S. Highway that runs from the Brookport Bridge over the Ohio River at Brookport...

U.S. Highway 45 (US 45) runs north–south through the eastern and northern portions of the state of Wisconsin. Also called Highway 45, it runs from the...

U.S. Route 45 Alternate (US 45 Alternate, also signed as US 45A) is a 62.9-mile-long (101.2 km) alternate route of US 45 in northeastern Mississippi, running...

1970s moved the routing of US 45 near Rockland before it was reversed soon afterwards. A segment of roadway that formerly carried US 45 is the site of...

In the U.S. state of Alabama, U.S. Route 45 (US 45) is a 60-mile-long (97 km) north–south United States Highway in the east south central state of Alabama...

U.S. Route 45 (US 45) in Tennessee extends from the Mississippi state line to the Kentucky state line in West Tennessee, passing through the cities of...

U.S. Route 45 (US 45) enters Kentucky at Fulton in Fulton County and travels northeast through Hickman County, Graves County, and McCracken County. After...

U.S. Route 54 (US 54) is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville...

U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 111 (US 111) was a U.S. Highway that extended from Baltimore, Maryland north to the Harrisburg, Pennsylvania area. It replaced part of the...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 98 (US 98) is an east–west United States Highway in the Southeastern United States that runs from western Mississippi to southern Florida....

U.S. Route 82 (US 82) is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern...

U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England....

U.S. Route 287 (US 287) is a north–south (physically northwest–southeast) United States highway. At 1,791 miles (2,882 km) long,[citation needed] it is...

U.S. Route 85 (US 85) is a 1,479-mile-long (2,380 km) north–south United States Highway that travels in the Mountain and Northern Plains states of the...

U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North...

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South...

U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west...

U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs 1,099 miles (1,769 km) from Biddles Corner, Delaware...

U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky. US 31E begins as the Ellington...

U.S. Route 10 or U.S. Highway 10 (US 10) is an east–west United States Numbered Highway located in the Midwest and Great Lakes regions of the U.S. Despite...

U.S. Route 641 (US 641) is a U.S. Route in Tennessee and Kentucky. It runs for 165.45 miles (266.27 km) from US 64 south of Clifton, Tennessee to an intersection...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 93 (US 93) is a major north–south 1,359-mile (2,187 km) U.S. Numbered Highway in the western United States, that connects U.S. Route 60 (US 60)...