• The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved...
    31 KB (3,592 words) - 02:08, 11 November 2024
  • mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPRmt results from unfolded or misfolded proteins in...
    17 KB (1,878 words) - 03:38, 2 December 2024
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    specific effects on virulence. A number of studies found that the unfolded protein response contributes to virulence of A. fumigatus. The lifecycle of filamentous...
    44 KB (4,593 words) - 21:58, 22 August 2024
  • degradation processes. When proteins are determined to be unfolded or misfolded, they are typically degraded via the unfolded protein response (UPR) or...
    25 KB (2,922 words) - 16:16, 10 January 2024
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    of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast". Biochemical and Biophysical Research Communications...
    31 KB (3,521 words) - 20:22, 5 December 2024
  • Thumbnail for Peter Walter
    correctly. This pathway is termed the unfolded protein response (UPR). However, how cells sense misfolded proteins and relays this information to the cell...
    35 KB (2,745 words) - 21:44, 16 November 2024
  • UPR may refer to: Unfolded protein response, a biological response in the "endoplasmic reticulum" when some proteins did not properly fold Union Pacific...
    2 KB (260 words) - 12:28, 22 October 2024
  • between unfolded protein response (UPR) responses and autophagy, oxidative stress, and inflammatory response signals in ER stress: aggregation of unfolded/misfolded...
    11 KB (1,323 words) - 15:00, 6 November 2024
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    stress response and the unfolded protein response (UPR). Conditions that exceed capacity of the ER provoke ER stress and trigger the unfolded protein response...
    12 KB (1,418 words) - 02:31, 30 August 2024
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    unfolded protein response, its disruption could be linked with neurodegenerative diseases, wherein the accumulation of intracellular toxic proteins serves...
    22 KB (2,089 words) - 07:06, 2 October 2024
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    JA, Eyholzer M, Timchenko NA, Mueller BU, Pabst T (Jun 2010). "Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid...
    20 KB (2,452 words) - 10:42, 21 November 2024
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    in the accumulation of misfolded proteins. As there is a high level of misfolded protein, unfolded protein response (UPR) is stimulated and lead to transcriptional...
    42 KB (5,032 words) - 19:33, 17 December 2024
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    stress-induced death. It exerts this action by binding to ERN1, the unfolded protein response (UPR) sensor in the ER, which results in the attenuation of UPR...
    5 KB (673 words) - 01:16, 26 November 2024
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    of ER calcium stores leads to ER stress and activation of the unfolded protein response. Non-resolved ER stress can cumulatively lead to cell death. Prolonged...
    14 KB (1,360 words) - 05:08, 11 February 2024
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    triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression...
    9 KB (1,033 words) - 20:06, 29 January 2023
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    folded proteins are transported from the rough ER to the Golgi apparatus – unfolded proteins cause an unfolded protein response as a stress response in the...
    33 KB (3,711 words) - 10:43, 22 December 2024
  • Thumbnail for Kazutoshi Mori
    1958) is a Japanese molecular biologist known for research on unfolded protein response. He is a professor of Biophysics at the Graduate School of Science...
    10 KB (815 words) - 23:22, 16 July 2024
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    Exercise-induced PGC-1α in skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may also be involved in controlling blood pressure, regulating...
    32 KB (3,869 words) - 02:23, 25 December 2024
  • "Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β induction via X-box binding protein 1". European Journal of Immunology...
    59 KB (6,001 words) - 01:48, 10 December 2024
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    researched, with the main hypotheses being mislocalization of ELANE or unfolded protein response (UPR) induced by mutant ELANE, however according to Mehta et al...
    23 KB (2,435 words) - 11:25, 3 June 2024
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    ATF/cAMP response elements and ER stress-response elements, binding the promoters and inducing transcription of several genes involved in unfolded protein response...
    48 KB (5,471 words) - 01:51, 23 September 2024
  • Thumbnail for Protein kinase R
    eIF2α. ER stress caused by excess of unfolded proteins leads to inflammatory responses. PKR contributes to this response by interacting with several inflammatory...
    39 KB (4,414 words) - 07:13, 30 December 2024
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    causes the protein to be misfolded, initiating the unfolded protein response (UPR), a pro-inflammatory endoplasmic reticulum (ER) stress response. Although...
    17 KB (1,589 words) - 15:08, 23 December 2024
  • sensitive to endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR). Severe or prolonged episodes of ER stress can lead to the...
    8 KB (958 words) - 17:05, 28 August 2024
  • Thumbnail for Apoptosis regulator BAX
    Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene...
    18 KB (2,092 words) - 13:58, 29 November 2024
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    necessary for protein folding, so skin cells may initiate the unfolded protein response which releases cytokines, thus mounting an immune response The National...
    42 KB (4,414 words) - 18:38, 4 December 2024
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    cells and other systems, and as such induces ER stress and the Unfolded Protein Response (UPR) pathway. 2-DG has been used as a targeted optical imaging...
    11 KB (1,079 words) - 15:01, 18 May 2024
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    mammary tumors as part of the unfolded protein response. Derlin-1 has been shown to interact with the following proteins: HRD1 VIMP US11 Derlin-2 Derlin-3...
    20 KB (2,259 words) - 11:05, 11 February 2024
  • Thumbnail for Parkin (protein)
    Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...
    47 KB (5,731 words) - 11:29, 22 June 2024
  • Dissection of the Unfolded Protein Response” the researchers suppressed multiple genes in each cell to study the unfolded protein response (UPR) pathway....
    21 KB (2,588 words) - 18:53, 19 April 2024