referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors. Allosteric regulations are a natural...
37 KB (4,437 words) - 20:55, 13 August 2024
allostery within single enzymes. In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule...
8 KB (1,027 words) - 11:08, 4 July 2022
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli...
19 KB (2,293 words) - 20:29, 8 July 2024
Pyruvate kinase (section Allosteric effectors)
fructose-1,6-bisphosphate (FBP), which serves as an allosteric effector for the enzyme. Allosteric regulation is the binding of an effector to a site on the...
33 KB (4,042 words) - 02:51, 1 February 2024
Malate dehydrogenase (section Allosteric regulation)
studies have proposed and experimentally demonstrated that citrate is an allosteric regulator of malate dehydrogenase depending on the concentrations of L-malate...
22 KB (2,401 words) - 23:24, 7 November 2023
Enzyme (redirect from Regulation mechanism)
Eiki J, Nagata Y (March 2004). "Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase". Structure. 12 (3): 429–438...
96 KB (9,819 words) - 12:03, 26 July 2024
hyperinsulinism-hyperammonemia syndrome. Allosteric regulation: This protein may use the morpheein model of allosteric regulation. Allosteric inhibitors: Guanosine triphosphate...
15 KB (1,654 words) - 16:29, 28 July 2024
of enzyme inhibitors. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. In some cases, when a substrate...
4 KB (574 words) - 11:29, 13 August 2024
Phosphofructokinase 1 (section Regulation)
most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors...
22 KB (2,567 words) - 19:24, 8 August 2024
Zinc is essential for enzymatic activity. The structural basis for allosteric regulation of Porphobilinogen synthase (PBGS) is modulation of a quaternary...
17 KB (1,918 words) - 18:27, 25 July 2024
Coenzyme A (section Regulation)
pathways. Acetyl-CoA is utilised in the post-translational regulation and allosteric regulation of pyruvate dehydrogenase and carboxylase to maintain and...
26 KB (2,528 words) - 21:25, 28 August 2024
ximelagatran) Dabigatran Thrombin demonstrates a high level of allosteric regulation. Allosterism in thrombin is regulated by the exosites 1 and 2 and...
7 KB (821 words) - 09:44, 30 January 2023
importance to cellular function, they can play important roles in the allosteric regulation of enzymes. Some can be useful in measuring rates of metabolic processes...
2 KB (128 words) - 20:50, 24 April 2024
Citric acid cycle (section Regulation)
reprogramming, cell growth, and migration.[citation needed] Allosteric regulation by metabolites. The regulation of the citric acid cycle is largely determined by...
56 KB (6,064 words) - 21:43, 12 September 2024
Ribonucleotide reductase (section Regulation)
aspartate (D64) and valine (V292 or V284), that are necessary in allosteric regulation; proline (P210 and P610), leucine (L453 and L473), and methionine...
35 KB (3,620 words) - 09:43, 1 August 2024
Interconversion of morpheein forms can be a structural basis for allosteric regulation, an idea noted many years ago, and later revived. A mutation that...
81 KB (6,785 words) - 21:20, 1 August 2024
ability of lac repressor bound with allolactose is inhibited due to allosteric regulation, thereby genes coding for proteins involved in lactose uptake and...
15 KB (1,684 words) - 05:17, 1 September 2024
Bohr effect (section Allosteric interactions)
the physiological implications of this phenomenon remain unclear. Allosteric regulation Haldane effect Root effect Chloride shift Bohr; Hasselbalch, Krogh...
18 KB (2,334 words) - 10:18, 27 March 2023
PMID 15158709. Ahmad MF, Dealwis CG (2013). "The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase". Oligomerization in Health and Disease...
24 KB (2,528 words) - 15:02, 22 February 2024
Glycolysis (section Regulation)
by metabolites such as ATP serves as negative feedback regulation of the pathway. Allosteric inhibition and activation by Protein-protein interactions...
83 KB (8,811 words) - 22:47, 12 September 2024
Phenylalanine hydroxylase (section Enzyme regulation)
then reduced to BH4. PAH is proposed to use the morpheein model of allosteric regulation. Mammalian PAH exists in an equilibrium consisting of tetramers...
31 KB (3,687 words) - 05:50, 12 August 2024
Acetyl-CoA carboxylase (section Regulation)
directly.[citation needed] This protein may use the morpheein model of allosteric regulation. At the juncture of lipid synthesis and oxidation pathways, ACC...
27 KB (2,990 words) - 21:27, 4 July 2024
are regulated vary. Prokaryotic PRK's are typically subject to allosteric regulation while eukaryotic PRK's are often regulated by reversible thiol/disulfide...
19 KB (2,067 words) - 01:25, 21 April 2024
point of regulation in saturated straight-chain fatty acid synthesis, and is subject to both phosphorylation and allosteric regulation. Regulation by phosphorylation...
41 KB (4,751 words) - 20:26, 4 September 2024
serves as regulation of activity of an enzyme by its direct product(s) or downstream metabolite(s) in the metabolic pathway (see Allosteric regulation). The...
48 KB (5,806 words) - 11:10, 14 September 2024
point of regulation in saturated straight-chain fatty acid synthesis, and is subject to both phosphorylation and allosteric regulation. Regulation by phosphorylation...
50 KB (5,561 words) - 07:03, 13 August 2024
Metabolism (redirect from Metabolic regulation)
flux through the pathway to compensate. This type of regulation often involves allosteric regulation of the activities of multiple enzymes in the pathway...
113 KB (12,400 words) - 00:04, 12 September 2024
With Jean-Pierre Changeux and François Jacob, Monod proposed a theory of allosteric transitions to explain how conformational effects could allow enzyme effectors...
23 KB (2,791 words) - 09:07, 13 September 2024
Phosphofructokinase (section Regulation)
2 similar domains). This protein may use the morpheein model of allosteric regulation. PFK is about 300 amino acids in length, and structural studies...
10 KB (1,044 words) - 08:43, 10 June 2024
and ligand designs including those with utility in catalysis and allosteric regulation. There are three main components of the WLA methodology that enable...
20 KB (2,242 words) - 15:36, 13 December 2023