Homeotic protein bicoid is encoded by the bcd maternal effect gene in Drosophilia. Homeotic protein bicoid concentration gradient patterns the anterior-posterior...

specific set of gap or pair-rule genes. In flies, stripe 2 in the embryo is activated by the maternal proteins Bicoid and Hunchback, but repressed by the...

regulated by the bicoid gene in Drosophila. However, in the red flour beetle, there is no bicoid orthologue, but instead the genes orthodenticle and...

genes involved in segmentation, the pair-rule genes. The gap genes themselves are expressed under the control of maternal effect genes such as bicoid...

differentiation. Maternal-effect genes help to define the anterior-posterior axis using Bicoid (gene) and Nanos (gene). Gap genes establish 3 broad segments...

The bicoid 3′-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila melanogaster...

development, the genes nanos and bicoid are asymmetrically expressed in the oocyte because maternal cells deposit messenger RNA (mRNA) for these genes in the poles...

number of genes produce messenger RNAs that set up concentration gradients along the long axis of the embryo. In the early embryo, the bicoid and hunchback...

for by master regulatory genes, and either activate or deactivate the transcription of other genes; in turn, these secondary gene products can regulate the...

is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of...

Lawrence. Christiane Nüsslein-Volhard was the first to identify a morphogen, Bicoid, one of the transcription factors present in a gradient in the Drosophila...

embryo. This allows the maternal effect genes Hunchback, Bicoid, Nanos, and Caudal to regulate zygotic genes to create different identities for different...

a tumor suppressor gene. The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role...

the blastoderm, bicoid in low concentrations is sufficient to activate otd expression through an enhancer located upstream of the otd gene. Later, in the...

establish concentration gradients that span the egg. Bicoid and Hunchback are the maternal effect genes that are most important for patterning of anterior...

target genes. Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can...

exposure of different amounts of Bicoid, Nanos, and other morphogens. Those nuclei with more Bicoid will activate genes that promote differentiation of...

transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity....

duplicated to give zen, zen2 and the even more divergent Bicoid gene. Large expansions of zen through gene duplication have also been observed within Lepidoptera...

homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity...

Peter Lawrence. Christiane Nüsslein-Volhard identified the first morphogen, Bicoid, one of the transcription factors present in a gradient in the Drosophila...

functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta and peroxisome...

is a gene that functions as a regulator of cellular growth and a proto oncogene. Zbtb7 is a member of the POK (POZ and Krüppel) family of genes, and the...

in humans is encoded by the KMT2A gene. MLL1 is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs...

GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes. The...

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for...

is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding to...

controlling the activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear...

including bicoid, dorsal, gurken and oskar. For example, embryos from homozygous bicoid mothers fail to produce head and thorax structures. Once the gene that...

2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression...