Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and anion channel in vertebrates that is encoded by the CFTR gene. Geneticist...
60 KB (6,439 words) - 21:50, 15 September 2024
in both copies (alleles) of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy...
161 KB (18,151 words) - 09:04, 27 September 2024
Elexacaftor/tezacaftor/ivacaftor (category Cystic fibrosis)
years and older with cystic fibrosis who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which...
38 KB (3,107 words) - 08:02, 24 June 2024
Sionna Therapeutics, for the development of a new cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a type of therapy that treats...
11 KB (957 words) - 22:06, 2 January 2024
Pancreatic disease (section Cystic fibrosis)
and early death. It is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The product of this gene helps create...
8 KB (843 words) - 18:23, 26 October 2023
Ivacaftor (category Cystic fibrosis)
medication used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (primarily...
34 KB (3,170 words) - 13:50, 20 September 2024
usual function. For example, cystic fibrosis is caused by a defective cystic fibrosis transmembrane conductance regulator (CFTR) protein, and in amyotrophic...
62 KB (4,598 words) - 21:08, 10 September 2024
Inflammatory cytokine (section In cystic fibrosis)
patients with cystic fibrosis show signs of asthma, possibly due to the primary deficiency in the cystic fibrosis transmembrane conductance regulator (CFTR)...
20 KB (2,259 words) - 11:36, 29 July 2024
the cystic fibrosis transmembrane conductance regulator. Secretin and VIP act to increase the opening of the cystic fibrosis transmembrane conductance regulator...
51 KB (5,703 words) - 20:00, 25 September 2024
Pyocyanin (section Cystic fibrosis)
Welsh M, Robertson A (2001). "Regulation of the cystic fibrosis transmembrane conductance regulator ClK channel by its R domain". Journal of Biological...
17 KB (1,971 words) - 18:28, 5 February 2024
Germline mutation (section Cystic fibrosis)
508 position. If both parents have a mutated CFTR (cystic fibrosis transmembrane conductance regulator) protein, then their children have a 25% of inheriting...
25 KB (3,085 words) - 03:46, 17 September 2024
Aggresome (section Cystic fibrosis)
linked to this protein when there is a protein. Cystic fibrosis transmembrane conductance regulator (CFTR) is an inefficiently folded integral membrane...
13 KB (1,654 words) - 14:17, 13 August 2023
caused by a mutation in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In approximately 10% of CF cases...
24 KB (2,582 words) - 14:38, 15 July 2024
Genetic heterogeneity (section Cystic Fibrosis)
that codes for the cystic fibrosis transmembrane conductance regulator. Research has identified over 2,000 cystic fibrosis associated mutations in the...
10 KB (1,248 words) - 21:52, 23 March 2024
(CNS). Barbiturates bind to the GABAA receptor at multiple homologous transmembrane pockets located at subunit interfaces, which are binding sites distinct...
44 KB (4,711 words) - 18:17, 24 September 2024
Chemical chaperone (section Cystic fibrosis)
diseases. Cystic fibrosis (CF) is a disease resulting from a failure to maintain the level of cystic fibrosis transmembrane conductance regulator (CFTR)...
11 KB (1,382 words) - 20:45, 8 January 2024
people with cystic fibrosis ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR)...
37 KB (3,631 words) - 14:27, 21 September 2024
for 10% of cases. This includes mutations of the cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal-type 1 (SPINK1)...
21 KB (2,091 words) - 15:35, 20 September 2024
Ductal cells (section Cystic fibrosis)
regeneration. Cystic fibrosis affects pancreatic ducts as well as many other secretory epithelia. Cystic fibrosis transmembrane conductance regulator (CFTR)...
15 KB (1,792 words) - 08:17, 16 August 2024
Cystic fibrosis (CF) is an autosomal recessive and monogenetic disorder. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator...
34 KB (3,174 words) - 07:09, 22 June 2024
water into the intestinal lumen, mainly by way of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel activation. This results in increased...
21 KB (1,620 words) - 01:33, 22 September 2024
Rahier, Jean-François (March 2001). "Frequency of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations and 5T Allele in Patients With Allergic...
37 KB (3,822 words) - 03:50, 8 September 2024
promoted Lyrica for other uses which had not been approved by medical regulators. For Lyrica and three other drugs, Pfizer was fined a record amount of...
99 KB (8,532 words) - 02:46, 3 October 2024
notably including cystic fibrosis, a genetic disorder in which a defect in the cystic fibrosis transmembrane conductance regulator protein impacts chloride...
35 KB (4,517 words) - 15:18, 1 August 2024
Channel blocker (section Cystic fibrosis)
(November 1996). "Disulphonic stilbene block of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in a mammalian cell line and...
26 KB (3,020 words) - 11:51, 16 January 2024
CaCCsTooltip Calcium-activated chloride channel CFTRTooltip Cystic fibrosis transmembrane conductance regulator Unsorted...
82 KB (8,641 words) - 07:55, 30 September 2024
findings in studies on men, since, in women, none of the large statin trials conducted prior to 2007 demonstrated a significant reduction in overall mortality...
80 KB (8,638 words) - 23:17, 18 September 2024
can be seen with certain point mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene commonly associated with congenital vas...
23 KB (2,531 words) - 05:29, 15 August 2024
acting as an antagonist to voltage-gated calcium channels (VGCCs). Studies conducted by Treistman et al. in the aplysia confirm inhibition of VGCC by ethanol...
29 KB (3,270 words) - 15:49, 13 July 2024
SPINK1, which codes for a trypsin inhibitor, or cystic fibrosis transmembrane conductance regulator. The differential diagnosis for pancreatitis includes...
42 KB (4,147 words) - 05:14, 29 September 2024