Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...
34 KB (3,959 words) - 11:00, 25 July 2024
The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family....
50 KB (5,330 words) - 03:50, 17 June 2024
and locomotor activity, mediating some behaviors and modulating dopamine receptor D2-mediated events. They play a role in addiction by facilitating the...
30 KB (3,450 words) - 22:12, 10 August 2024
to. The D1-like class of dopamine receptors is coupled to Gαs/olf and stimulates adenylate cyclase production, whereas the D2-like class is coupled to...
25 KB (2,401 words) - 02:56, 4 June 2024
A dopamine agonist is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled...
44 KB (5,009 words) - 01:01, 9 August 2024
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4...
36 KB (4,062 words) - 04:28, 17 June 2024
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype...
28 KB (3,177 words) - 08:06, 12 July 2024
antipsychotics. Dopamine supersensitivity may be caused by the dopamine receptor D2 antagonizing effect of antipsychotics, causing a compensatory increase in D2 receptors...
14 KB (1,609 words) - 00:40, 31 May 2024
Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with...
37 KB (4,376 words) - 11:01, 25 July 2024
The D1–D2 dopamine receptor heteromer is a receptor heteromer consisting of D1 and D2 protomers. D1 and D2 receptors interact primarily through discrete...
12 KB (1,255 words) - 23:01, 20 August 2023
Aripiprazole (category D2-receptor agonists)
the dopamine receptor (D2). Aripiprazole is a partial agonist at dopamine D2 receptors, partial agonist at 5-HT1A receptors and at 5-HT2A, receptors. It...
105 KB (9,662 words) - 00:07, 27 August 2024
Relapse (section Dopamine D2 receptor availability)
of the dopamine receptor D2 plays a role in self-administration and the reinforcing effects of cocaine and other stimulants. The D2 receptor availability...
23 KB (2,869 words) - 23:58, 12 December 2023
Tuberoinfundibular pathway (redirect from Tuberoinfundibular dopamine pathway)
anterior pituitary gland lactotrophs by binding to dopamine receptor D2. Some antipsychotic drugs block dopamine in the tuberoinfundibular pathway, which can...
2 KB (207 words) - 12:25, 30 July 2024
The D2-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D2-like subfamily consists of three...
1 KB (88 words) - 05:31, 6 July 2024
on decreased levels of dopamine activity due to: Dopamine receptor blockade Genetically reduced function of dopamine receptor D2 Sympathoadrenal hyperactivity...
33 KB (3,381 words) - 05:42, 22 April 2024
area contains a large population of type D2 dopamine receptors. Consequently, drugs that activate D2 receptors have a high potential to cause nausea. This...
137 KB (14,077 words) - 08:44, 17 July 2024
and DRD5) or D2-type (i.e., DRD2, DRD3, and DRD4) dopamine receptors. A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40%...
80 KB (9,795 words) - 16:39, 15 April 2024
Cariprazine (category Dopamine antagonists)
(300 μg/kg), the D2/D3 receptors were 94% occupied, while at the lowest dose (1 μg/kg), receptors were 5% occupied. Dopamine D2 and D3 receptor occupancy in...
31 KB (2,618 words) - 06:03, 18 May 2024
behavioural supersensitivity to dopamine and a marked rise in the number of dopamine D2 receptors in the high-affinity state for dopamine. This latter work implies...
46 KB (5,422 words) - 03:48, 5 August 2024
Cabergoline (category D2-receptor agonists)
taken by mouth. Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist. Cabergoline was patented in 1980 and approved for medical...
31 KB (2,792 words) - 16:22, 8 June 2024
System Dopamine receptor D2, a protein Levuglandin D2 Prostaglandin D2 receptor, a G-protein coupled receptor Resolvin D2 Cyclin D2 (CCND2) Vitamin D2, or...
5 KB (788 words) - 12:58, 23 July 2024
A2A receptor has been shown to interact with Dopamine receptor D2. As a result, Adenosine receptor A2A decreases activity in the Dopamine D2 receptors. The...
46 KB (5,102 words) - 19:50, 8 June 2024
Dopexamine (category D2-receptor agonists)
stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine...
13 KB (1,225 words) - 03:19, 20 October 2023
evidence indicates abnormal dopamine receptor D2 structure, as well as a reduced link between dopamine receptor D1 and receptor D2. Studies have shown that...
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disorders. Dopamine is now one of the primary neurotransmitters implicated in psychotic symptomology. Blocking dopamine receptors (namely, the dopamine D2 receptors)...
132 KB (14,932 words) - 01:31, 27 August 2024
respective main articles of the individual subtypes: D2-like receptor "Dopamine D1-Like Receptor Family Signaling Pathways". Rndsystems. 26 March 2022...
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Brexpiprazole (category D2-receptor agonists)
D2 receptor of 60%+, brexpiprazole has an intrinsic activity at the same receptor of about 45%. For aripiprazole, this means more dopamine receptor activation...
31 KB (2,342 words) - 16:44, 31 July 2024
Rotigotine (category D2-receptor agonists)
2015). "Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors". British Journal of Pharmacology. 172 (4):...
13 KB (1,068 words) - 11:46, 13 April 2024
Adderall (category Norepinephrine-dopamine releasing agents)
interval timing, whereas antagonists of D2 type dopamine receptors typically slow timing;... Depletion of dopamine in healthy volunteers impairs timing,...
58 KB (21,539 words) - 12:58, 7 August 2024
Bromocriptine (category Dopamine agonists)
agonist of the dopamine D2 receptor. It also interacts with other dopamine receptors and with various serotonin and adrenergic receptors. Bromocriptine...
24 KB (1,943 words) - 11:23, 27 April 2024