Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
63 KB (7,473 words) - 02:17, 23 July 2024
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6...
12 KB (1,289 words) - 19:20, 4 December 2023
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic...
11 KB (1,438 words) - 14:27, 22 December 2023
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
45 KB (4,194 words) - 12:36, 2 May 2024
Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first isolated...
22 KB (2,510 words) - 04:11, 12 August 2024
four-helical cytokine Interleukin-6 and the soluble Interleukin-6 receptor which are covalently linked by a flexible peptide linker. Interleukin-6 on target cells...
14 KB (1,664 words) - 11:41, 8 February 2024
Inflammaging (section Interleukin 6)
Rösel, Daniel; Dvořánková, Barbora; Smetana, Karel (26 October 2020). "Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19". International...
26 KB (3,020 words) - 17:03, 14 May 2024
is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind...
47 KB (5,296 words) - 02:18, 19 July 2024
reduce glial scarring. Interleukins are another potential family of scar-inducing cellular messengers. Particularly, interleukin-1, a protein produced...
24 KB (2,962 words) - 15:40, 7 June 2024
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
40 KB (4,858 words) - 14:50, 21 July 2024
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
22 KB (2,834 words) - 11:07, 29 July 2024
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
35 KB (3,989 words) - 13:32, 13 July 2024
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor...
12 KB (1,315 words) - 19:57, 6 May 2024
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
19 KB (2,293 words) - 11:05, 8 March 2024
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and...
26 KB (3,305 words) - 17:31, 8 August 2024
Myokine (section Interleukins)
myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin 6) was the first myokine found to be secreted into the blood stream in...
36 KB (4,573 words) - 00:48, 7 July 2024
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
18 KB (2,082 words) - 08:54, 18 March 2024
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
14 KB (1,578 words) - 14:00, 26 February 2024
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
13 KB (1,523 words) - 19:27, 26 June 2024
of myxoma may be associated with the release of interleukin 6 (IL-6) by the myxoma. High levels of IL-6 may be associated with a higher risk of embolism...
11 KB (770 words) - 17:19, 8 January 2024
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to...
49 KB (6,005 words) - 16:30, 10 June 2024
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
43 KB (5,000 words) - 13:28, 1 July 2024
producing pro-inflammatory cytokines such as interleukin-1, interleukin-6, interleukin-7, interleukin-8, interleukin-18, macrophage migration inhibitory factor...
38 KB (3,739 words) - 02:53, 15 July 2024
selectively blocks activities of the cytokine Interleukin-6, which are mediated by the soluble Interleukin-6. Interleukin-6 is a cytokine, which plays a dominant...
15 KB (1,691 words) - 18:04, 2 June 2024
It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune...
43 KB (3,662 words) - 19:35, 12 July 2024
Glycoprotein 130 (redirect from Interleukin 6 signal transducer)
8511589. PMID 8511589. Kishimoto T, Akira S, Narazaki M, Taga T (1995). "Interleukin-6 family of cytokines and gp130". Blood. 86 (4): 1243–1254. doi:10.1182/blood...
18 KB (2,202 words) - 01:16, 14 June 2024
discovered. Members include: Leptin Adiponectin Apelin chemerin interleukin-6 (IL-6) monocyte chemotactic protein-1 (MCP-1) plasminogen activator inhibitor-1...
4 KB (443 words) - 07:08, 27 April 2024
Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with...
53 KB (6,247 words) - 19:58, 2 April 2024
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
20 KB (2,192 words) - 23:02, 27 November 2023
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
24 KB (3,043 words) - 22:14, 16 June 2024