• A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses...
    46 KB (5,510 words) - 21:54, 29 November 2024
  • p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines...
    14 KB (1,385 words) - 10:32, 28 April 2024
  • Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein...
    3 KB (296 words) - 17:06, 14 September 2023
  • Thumbnail for C-Jun N-terminal kinases
    its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines...
    14 KB (1,626 words) - 20:50, 30 May 2024
  • Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP...
    11 KB (1,345 words) - 09:11, 2 January 2024
  • Thumbnail for AMP-activated protein kinase
    5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular...
    65 KB (7,149 words) - 14:04, 13 November 2024
  • a protein and produces some change in the cell, such as cell division. The pathway includes many proteins, such as mitogen-activated protein kinases (MAPKs)...
    24 KB (3,068 words) - 07:21, 7 June 2024
  • [citation needed] In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then...
    11 KB (1,128 words) - 03:46, 28 September 2024
  • Thumbnail for Protein kinase A
    It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase). Protein kinase A, more precisely known as adenosine 3'...
    27 KB (2,665 words) - 17:03, 6 April 2024
  • Thumbnail for Mitogen-activated protein kinase 9
    Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene is a member of the MAP kinase...
    7 KB (792 words) - 02:33, 19 October 2022
  • A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis is...
    13 KB (1,727 words) - 03:34, 17 November 2024
  • Thumbnail for Protein kinase B
    molecules, including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also serve as PDK2. Phosphorylation...
    35 KB (3,831 words) - 18:08, 20 August 2024
  • Thumbnail for Protein kinase
    important group of protein kinases are the MAP kinases (acronym from: "mitogen-activated protein kinases"). Important subgroups are the kinases of the ERK subfamily...
    15 KB (1,635 words) - 23:25, 13 August 2024
  • Thumbnail for MAP2K1
    Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene...
    13 KB (1,478 words) - 04:12, 19 August 2024
  • Thumbnail for ASK1
    signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein...
    19 KB (2,222 words) - 13:54, 29 November 2024
  • Thumbnail for MAPKAPK2
    "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical Journal. 296 ( Pt 3) (Pt...
    16 KB (1,726 words) - 11:03, 11 April 2024
  • Thumbnail for RAF kinase
    as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members...
    5 KB (556 words) - 08:06, 3 June 2024
  • PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and...
    29 KB (2,856 words) - 15:13, 2 December 2024
  • Thumbnail for MAPK8
    Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this...
    16 KB (1,781 words) - 00:37, 15 June 2024
  • Thumbnail for Mitogen-activated protein kinase kinase kinase 6
    Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. This gene encodes a serine/threonine protein...
    4 KB (546 words) - 22:00, 3 December 2023
  • Thumbnail for MAPK1
    Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this...
    20 KB (2,283 words) - 00:38, 15 June 2024
  • The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates...
    14 KB (1,447 words) - 09:31, 22 December 2023
  • Thumbnail for MAPK14
    Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38α mitogen-activated...
    44 KB (5,265 words) - 05:22, 10 July 2024
  • Thumbnail for CGMP-dependent protein kinase
    cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number...
    8 KB (825 words) - 21:37, 20 April 2023
  • kinase cascades to greatly amplify the strength of the original first messenger signal. For example, RasGTP signals link with the mitogen activated protein...
    12 KB (1,338 words) - 08:26, 24 July 2023
  • an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular...
    8 KB (886 words) - 12:46, 31 January 2024
  • Thumbnail for Rho-associated protein kinase
    Rho-associated protein kinase or Rho-associated coiled-coil kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific...
    19 KB (2,173 words) - 17:14, 20 December 2024
  • Thumbnail for Ca2+/calmodulin-dependent protein kinase II
    Ca2+ /calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+ /calmodulin...
    29 KB (3,458 words) - 01:05, 2 November 2024
  • Thumbnail for P70-S6 Kinase 1
    Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans...
    18 KB (2,130 words) - 04:34, 16 November 2024
  • Thumbnail for Scaffold protein
    the activation of these signaling proteins. An example is the Ste5 scaffold in the mitogen-activated protein kinase (MAPK) pathway. Ste5 has been proposed...
    25 KB (2,159 words) - 11:01, 3 August 2024