Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is a humanized monoclonal...

antipsychotics, especially in elderly patients with dementia. As of 2006[update], natalizumab (marketed as Tysabri) received a boxed warning on its packaging due to...

various transplant drugs, which are meant to weaken the immune system. Natalizumab (Tysabri) was approved in 2004 by the FDA for the treatment of multiple...

beta 1a and natalizumab: Dangerous but effective. Linked with PML, but is remarkable that Natalizumab alone is also linked with it. Natalizumab and fingolimod...

et al. (International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group; Evaluation of Natalizumab as Continuous Therapy (ENACT-2)...

confidence that natalizumab, cladribine, or alemtuzumab are decreasing relapses over a period of two years for people with RRMS. Natalizumab and interferon...

system disorders; and rare reports of cardiac failure.[citation needed] Natalizumab is an anti-integrin monoclonal antibody that has shown utility as induction...

1146/annurev.immunol.19.1.163. PMID 11244034. Doggrell SA (June 2003). "Is natalizumab a breakthrough in the treatment of multiple sclerosis?". Expert Opinion...

treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin antagonists like ustekinumab. Prior to the development...

reported in patients treated with the drug. The boxed warning for the drug natalizumab (Tysabri) includes a statement that Human polyomavirus 2 resulted in...

focused on physiological and neuropathic pain. Previously named Antegren, natalizumab is a drug co-marketed by Biogen Idec and Élan as "Tysabri". Tysabri is...

against the therapeutic antibody) infliximab -zumab humanized antibody natalizumab, bevacizumab -anib Angiogenesis inhibitors pazopanib, vandetanib -ciclib...

2023 adalimumab-aaty/Yuflyma adalimumab/Humira August 2023 natalizumab-sztn/Tyruko natalizumab/Tysabri September 2023 tocilizumab-bavi/Tofidence tocilizumab/Actemra...

hepatitis. Muzolimine 1987 France, Germany, European Union Polyneuropathy. Natalizumab (Tysabri) 2005–2006 US Voluntarily withdrawn from US market because of...

L04AF08 Ritlecitinib L04AG01 Muromonab-CD3 L04AG02 Efalizumab L04AG03 Natalizumab L04AG04 Belimumab L04AG05 Vedolizumab L04AG06 Alemtuzumab L04AG07 Begelomab...

developing progressive multifocal leukoencephalopathy during treatment with natalizumab". Annals of Neurology. 77 (3): 447–457. doi:10.1002/ana.24345. PMID 25581547...

FDA include: interferons beta-1a and beta-1b; monoclonal antibodies: natalizumab, alemtuzumab, ocrelizumab, ofatumumab, and ublituximab; and immunomodulators:...

produce IL-1β. Treatment of multiple sclerosis with glatiramer acetate or natalizumab has also been shown to reduce the presence of IL-1β or its receptor....

(dimethyl fumarate) Relapsing forms of multiple sclerosis 2013 2014 TYSABRI (natalizumab) Relapsing-remitting multiple sclerosis 2004 Re-introduced in 2006 2006...

have been reported, which has also been reported in patients taking natalizumab (Tysabri), an approved multiple sclerosis drug. Fingolimod has also been...

emtansine mab chimeric CD37 Narnatumab mab human MST1R (aka RON) cancer Natalizumab Tysabri mab humanized integrin α4 Y multiple sclerosis, Crohn's disease...

Lampalizumab† Letolizumab Ligelizumab† Lulizumab pegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab Omalizumab Ozoralizumab Pascolizumab Pateclizumab Pembrolizumab...

Merck KGaA 4 $1.93 billion Fingolimod Gilenya Novartis 5 $1.41 billion Natalizumab Tysabri Biogen Idec 6 $1.38 billion Interferon beta 1b Betaseron/Betaferon...

an autoimmune reaction has been to block the action of VLA-4 (as with natalizumab) so that pathogenic T-cells are unable to enter the brain and thus unable...

stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab". Journal of Neurology. 255 (9): 1436–1438. doi:10.1007/s00415-008-0956-x...

GlaxoSmithKline 11/4/2015 subcutaneous humanized IL5 Severe asthma 125526 Link natalizumab Tysabri Biogen Idec 11/23/2004 intravenous humanized alpha-4 integrin...

Ruplizumab BLyS Belimumab CAT Bertilimumab Lerdelimumab Metelimumab Integrin Natalizumab Vedolizumab Interleukin-6 receptor Tocilizumab LFA-1 Odulimomab IL-2...

research leading to the first approved monoclonal antibody therapy for MS, Natalizumab (Tysabri), and clarified the molecular basis for how EBV triggers MS...

immunosuppressants used to treat MS—such as interferon-β, fingolimod, natalizumab, and alemtuzumab—worsen NMO disease progression and should not be used...

Nasarel nasaruplase (INN) nasaruplase beta (INN) Nascobal Nasonex Natacyn natalizumab (INN) natamycin (INN) nateglinide (INN) nateplase (INN) Natrecor Naturetin...