Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is a humanized monoclonal...
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antipsychotics, especially in elderly patients with dementia. As of 2006[update], natalizumab (marketed as Tysabri) received a boxed warning on its packaging due to...
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various transplant drugs, which are meant to weaken the immune system. Natalizumab (Tysabri) was approved in 2004 by the FDA for the treatment of multiple...
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Multiple sclerosis drug pipeline (section Natalizumab)
beta 1a and natalizumab: Dangerous but effective. Linked with PML, but is remarkable that Natalizumab alone is also linked with it. Natalizumab and fingolimod...
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et al. (International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group; Evaluation of Natalizumab as Continuous Therapy (ENACT-2)...
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confidence that natalizumab, cladribine, or alemtuzumab are decreasing relapses over a period of two years for people with RRMS. Natalizumab and interferon...
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Management of Crohn's disease (section Natalizumab)
system disorders; and rare reports of cardiac failure.[citation needed] Natalizumab is an anti-integrin monoclonal antibody that has shown utility as induction...
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1146/annurev.immunol.19.1.163. PMID 11244034. Doggrell SA (June 2003). "Is natalizumab a breakthrough in the treatment of multiple sclerosis?". Expert Opinion...
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treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin antagonists like ustekinumab. Prior to the development...
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reported in patients treated with the drug. The boxed warning for the drug natalizumab (Tysabri) includes a statement that Human polyomavirus 2 resulted in...
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focused on physiological and neuropathic pain. Previously named Antegren, natalizumab is a drug co-marketed by Biogen Idec and Élan as "Tysabri". Tysabri is...
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against the therapeutic antibody) infliximab -zumab humanized antibody natalizumab, bevacizumab -anib Angiogenesis inhibitors pazopanib, vandetanib -ciclib...
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2023 adalimumab-aaty/Yuflyma adalimumab/Humira August 2023 natalizumab-sztn/Tyruko natalizumab/Tysabri September 2023 tocilizumab-bavi/Tofidence tocilizumab/Actemra...
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hepatitis. Muzolimine 1987 France, Germany, European Union Polyneuropathy. Natalizumab (Tysabri) 2005–2006 US Voluntarily withdrawn from US market because of...
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L04AF08 Ritlecitinib L04AG01 Muromonab-CD3 L04AG02 Efalizumab L04AG03 Natalizumab L04AG04 Belimumab L04AG05 Vedolizumab L04AG06 Alemtuzumab L04AG07 Begelomab...
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developing progressive multifocal leukoencephalopathy during treatment with natalizumab". Annals of Neurology. 77 (3): 447–457. doi:10.1002/ana.24345. PMID 25581547...
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FDA include: interferons beta-1a and beta-1b; monoclonal antibodies: natalizumab, alemtuzumab, ocrelizumab, ofatumumab, and ublituximab; and immunomodulators:...
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produce IL-1β. Treatment of multiple sclerosis with glatiramer acetate or natalizumab has also been shown to reduce the presence of IL-1β or its receptor....
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(dimethyl fumarate) Relapsing forms of multiple sclerosis 2013 2014 TYSABRI (natalizumab) Relapsing-remitting multiple sclerosis 2004 Re-introduced in 2006 2006...
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have been reported, which has also been reported in patients taking natalizumab (Tysabri), an approved multiple sclerosis drug. Fingolimod has also been...
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emtansine mab chimeric CD37 Narnatumab mab human MST1R (aka RON) cancer Natalizumab Tysabri mab humanized integrin α4 Y multiple sclerosis, Crohn's disease...
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Lampalizumab† Letolizumab Ligelizumab† Lulizumab pegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab Omalizumab Ozoralizumab Pascolizumab Pateclizumab Pembrolizumab...
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Merck KGaA 4 $1.93 billion Fingolimod Gilenya Novartis 5 $1.41 billion Natalizumab Tysabri Biogen Idec 6 $1.38 billion Interferon beta 1b Betaseron/Betaferon...
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an autoimmune reaction has been to block the action of VLA-4 (as with natalizumab) so that pathogenic T-cells are unable to enter the brain and thus unable...
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stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab". Journal of Neurology. 255 (9): 1436–1438. doi:10.1007/s00415-008-0956-x...
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GlaxoSmithKline 11/4/2015 subcutaneous humanized IL5 Severe asthma 125526 Link natalizumab Tysabri Biogen Idec 11/23/2004 intravenous humanized alpha-4 integrin...
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Ruplizumab BLyS Belimumab CAT Bertilimumab Lerdelimumab Metelimumab Integrin Natalizumab Vedolizumab Interleukin-6 receptor Tocilizumab LFA-1 Odulimomab IL-2...
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research leading to the first approved monoclonal antibody therapy for MS, Natalizumab (Tysabri), and clarified the molecular basis for how EBV triggers MS...
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immunosuppressants used to treat MS—such as interferon-β, fingolimod, natalizumab, and alemtuzumab—worsen NMO disease progression and should not be used...
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Nasarel nasaruplase (INN) nasaruplase beta (INN) Nascobal Nasonex Natacyn natalizumab (INN) natamycin (INN) nateglinide (INN) nateplase (INN) Natrecor Naturetin...
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