Neuregulin 1, or NRG1, is a gene of the epidermal growth factor family that in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the...

Neuregulins are a family of four structurally related proteins that are part of the EGF family of proteins. These proteins have been shown to have diverse...

SOX10 might influence early glial precursors to respond to neuregulin 1 (see below). Neuregulin 1 (NRG1) acts in a number of ways to both promote the formation...

Epiregulin (EPR) Epigen Betacellulin (BTC) neuregulin-1 (NRG1) neuregulin-2 (NRG2) neuregulin-3 (NRG3) neuregulin-4 (NRG4). All family members contain one...

protein (HGFLP) Myostatin (GDF-8) Neuregulins Neuregulin 1 (NRG1) Neuregulin 2 (NRG2) Neuregulin 3 (NRG3) Neuregulin 4 (NRG4) Neurotrophins Brain-derived...

with schizophrenia-like behavioural deficits. The gene NRG1 codes for neuregulin 1, a growth factor which is crucial to the development of the nervous system...

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family...

Neuregulin 3, also known as NRG3, is a neural-enriched member of the neuregulin protein family which in humans is encoded by the NRG3 gene. The NRGs are...

clinical efficacy in HER2 overexpressing breast cancers by disrupting a neuregulin-1 (NRG1)-mediated autocrine loop. In the case of PDGFR signalling, overexpression...

dystrobrevin binding protein 1 (DTNBP1), neuregulin 1 (NRG1), disrupted in schizophrenia 1 (DISC1), and neuregulin 1 receptor (ERBB4), as being possibly...

Party Neuregulins: Neuregulin 1 or NRG1 Neuregulin 2 or NRG2 Neuregulin 3 or NRG3 Neuregulin 4 or NRG4 Psychoactive compounds: Naphyrone (NRG-1) 4-MEC...

disorder becomes.[citation needed] Common and rare DNA variations in the neuregulin 1 (NRG1) and NRG3 (NRG3) were first shown to be associated with the disease...

receptor adopts a conformation that inhibits dimerization. Binding of neuregulin to the ligand binding subdomains (I and III) induces a conformational...

observed that BACE1 is involved in myelination (it is co-express with neuregulin 1 type III). In a manner analogous to APP processing, the VGSC subunit...

cognition itself. Studies in the early 2000s mapped the involvement of the Neuregulin 1 gene in schizophrenia, leading to substantial research in this novel...

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. The neuregulins, including NRG4...

ejection fraction appears to be reversible. Trastuzumab downregulates neuregulin-1 (NRG-1), which is essential for the activation of cell survival pathways...

theory, Zensun has successfully developed two drugs: Recombinant Human Neuregulin-1 injection, an anti-heart failure drug, and Recombinant Human ErbB3 fragment...

trophic factors - like ciliary neurotrophic factor (CNTF), cytokines or neuregulin 1 (NRG1) - that can determine whether the cells will differentiate into...

glutamate receptors may be partially explained by altered reelin cascades. Neuregulin 1 deficits may also be involved in glutaminergic hypofunction as NRG1 hypofunction...

intracellular cell signaling pathways in response to a paracrine growth factor Neuregulin-1 in the cardiac myocyte. This research shed light on the effects of...

associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling...

Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon Navigation". Cell. 125 (1): 127–142. doi:10.1016/j.cell.2006.01.042. PMC 2365888...

arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs...

work on autism. His research on Neuregulin-1 revealed a possible function in CNS neurogenesis since the neuregulins were labeled throughout proliferation...

of neurotrophic factors are composed of epidermal growth factor, the neuregulins, transforming growth factor alpha (TGFα), and transforming growth factor...

breakthrough of 2003. In a later paper, he analyzed the activity of the gene Neuregulin-1 in a large collection of brain samples from schizophrenic patients and...

23 exons. TMTC4 has seven isoform variants, the most common being isoform 1 at 4043 bp. The 5’ UTR for TMTC4 is short and in many of the shorter isoforms...

Osborne, J Munro, DS Clair, DA Collier, et al. An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. Psychiatric genetics...

et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726...