Pleiotropy (from Greek πλείων pleion, 'more', and τρόπος tropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits...

The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an...

In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects...

Strawberry roan, or chestnut roan, is a horse coat color consisting of a mixture of reddish-brown and white hairs in varying proportions, stable over the...

classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest that environmental factors, such as predation...

Biology of Aging exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one...

of mutations (evolution of ageing), disposable soma and antagonistic pleiotropy hypothesis. The molecular theories of ageing include phenomena such as...

putative cause for the broad changes seen in domestication syndrome is pleiotropy. Pleiotropy occurs when one gene influences two or more seemingly unrelated...

pleiotropy in the interleukin-4/13 system", Cell, 132(2):259-72. Ozaki, K; Leonard, WJ (16 August 2002). "Cytokine and cytokine receptor pleiotropy and...

evolution such as kin selection and inclusive fitness, or antagonistic pleiotropy that favors heterozygotes and homosexuality among homozygotes as a by-product...

the distribution of allelic and mutational effects, and patterns of pleiotropy, dominance, and epistasis. There are several different experimental views...

exposure. This is known as the "exclusion restriction" or "no horizontal pleiotropy" assumption. To ensure that the first core assumption is validated, Mendelian...

A very simple genotype–phenotype map that only shows additive pleiotropy effects....

better explained as a by-product of adaptive traits caused by antagonistic pleiotropy and by genes that are retained due to a fitness landscape with an asymmetric...

would include information about the patient's covariates. Every novel pleiotropy discovery will need further biological validation to ensure that the data-driven...

Such a genetic effect is called the antagonistic pleiotropy effect when referring to a gene (pleiotropy signifying the gene has a double function – enabling...

There is also a hypothesis that female genital evolution is the result of pleiotropy, i.e. unrelated genes that are affected by environmental conditions like...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

"Investigating cognitive transfer within the framework of music practice: genetic pleiotropy rather than causality". Developmental Science. 19 (3): 504–512. doi:10...

diseases, and sepsis. Glucocorticoids have many diverse effects such as pleiotropy, including potentially harmful side effects. They also interfere with...

and criminality, were hereditary because these traits were subjective. Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic...

the genetic influences on a different trait estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and...

Antagonistic pleiotropy is a theory proposed as an alternative by George C. Williams, a critic of Medawar, in 1957. In antagonistic pleiotropy, genes carry...

Nocebo Patient safety Perioperative mortality Pharmacotoxicology Placebo Pleiotropy (drugs) Polypharmacy Toxicology Edwards, I. Ralph; Aronson, Jeffrey K...

Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...

many biologists. According to Affifi (2017), "With the discoveries of pleiotropy and epistasis, cracks in the reductionist paradigm emerged even before...

specification, and adaptation, probably promoted by their low level of pleiotropy. As early as the 1930s, J. B. S. Haldane and others suggested that copies...

between the diseases One disease resulting from complications of another Pleiotropy The factors responsible for the development of comorbidity can be chronic...