Pleiotropy (from Greek πλείων pleion, 'more', and τρόπος tropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits...
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The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an...
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In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects...
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Strawberry roan (section Health and pleiotropy)
Strawberry roan, or chestnut roan, is a horse coat color consisting of a mixture of reddish-brown and white hairs in varying proportions, stable over the...
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Evolution of ageing (section Antagonistic pleiotropy)
classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest that environmental factors, such as predation...
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Michael R. Rose (section Antagonistic pleiotropy)
Biology of Aging exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one...
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Senescence (section Antagonistic pleiotropy)
of mutations (evolution of ageing), disposable soma and antagonistic pleiotropy hypothesis. The molecular theories of ageing include phenomena such as...
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Domestication of vertebrates (section Pleiotropy)
putative cause for the broad changes seen in domestication syndrome is pleiotropy. Pleiotropy occurs when one gene influences two or more seemingly unrelated...
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pleiotropy in the interleukin-4/13 system", Cell, 132(2):259-72. Ozaki, K; Leonard, WJ (16 August 2002). "Cytokine and cytokine receptor pleiotropy and...
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evolution such as kin selection and inclusive fitness, or antagonistic pleiotropy that favors heterozygotes and homosexuality among homozygotes as a by-product...
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the distribution of allelic and mutational effects, and patterns of pleiotropy, dominance, and epistasis. There are several different experimental views...
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exposure. This is known as the "exclusion restriction" or "no horizontal pleiotropy" assumption. To ensure that the first core assumption is validated, Mendelian...
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A very simple genotype–phenotype map that only shows additive pleiotropy effects....
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better explained as a by-product of adaptive traits caused by antagonistic pleiotropy and by genes that are retained due to a fitness landscape with an asymmetric...
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would include information about the patient's covariates. Every novel pleiotropy discovery will need further biological validation to ensure that the data-driven...
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Such a genetic effect is called the antagonistic pleiotropy effect when referring to a gene (pleiotropy signifying the gene has a double function – enabling...
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There is also a hypothesis that female genital evolution is the result of pleiotropy, i.e. unrelated genes that are affected by environmental conditions like...
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Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...
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"Investigating cognitive transfer within the framework of music practice: genetic pleiotropy rather than causality". Developmental Science. 19 (3): 504–512. doi:10...
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diseases, and sepsis. Glucocorticoids have many diverse effects such as pleiotropy, including potentially harmful side effects. They also interfere with...
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and criminality, were hereditary because these traits were subjective. Pleiotropy occurs when one gene influences multiple, seemingly unrelated phenotypic...
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the genetic influences on a different trait estimating the degree of pleiotropy or causal overlap. A genetic correlation of 0 implies that the genetic...
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Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...
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genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and...
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Antagonistic pleiotropy is a theory proposed as an alternative by George C. Williams, a critic of Medawar, in 1957. In antagonistic pleiotropy, genes carry...
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Nocebo Patient safety Perioperative mortality Pharmacotoxicology Placebo Pleiotropy (drugs) Polypharmacy Toxicology Edwards, I. Ralph; Aronson, Jeffrey K...
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Other effects of ligand Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)...
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many biologists. According to Affifi (2017), "With the discoveries of pleiotropy and epistasis, cracks in the reductionist paradigm emerged even before...
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De novo gene birth (section Pleiotropy-barrier model)
specification, and adaptation, probably promoted by their low level of pleiotropy. As early as the 1930s, J. B. S. Haldane and others suggested that copies...
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between the diseases One disease resulting from complications of another Pleiotropy The factors responsible for the development of comorbidity can be chronic...
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