Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules...
56 KB (6,826 words) - 21:39, 26 August 2024
example being RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
8 KB (877 words) - 02:32, 21 May 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
141 KB (15,474 words) - 08:09, 11 August 2024
rasi/piRNA biogenesis.) Double-stranded RNAs capable of silencing repeat elements, then known as repeat associated small interfering RNA (rasiRNA), were...
44 KB (5,235 words) - 10:51, 22 February 2024
example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
47 KB (5,449 words) - 00:50, 6 August 2024
Telomerase (section Small interfering RNA (siRNA))
means of interfering with telomerase in cancer cells. Most of the harmful cancer-related effects of telomerase are dependent on an intact RNA template...
49 KB (5,644 words) - 06:05, 27 April 2024
ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)...
115 KB (12,353 words) - 08:50, 7 August 2024
triggers mRNA degradation by 5' decapping, 3' poly(A) tail removal, or endonucleolytic cleavage. In metazoans, small interfering RNAs (siRNAs) processed...
49 KB (5,922 words) - 14:24, 18 August 2024
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,836 words) - 14:30, 19 April 2024
involve the use of both small interfering RNA (siRNA) and micro RNA (miRNA) to prevent mRNA translation and/or degrade mRNA. However, RNA aptamers are short...
77 KB (8,886 words) - 09:03, 10 June 2024
Dicer (category RNA interference)
double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively...
25 KB (3,219 words) - 05:09, 24 July 2024
Inclisiran (category Small interfering RNA)
and heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA (siRNA) that acts as an inhibitor of a proprotein convertase, specifically...
21 KB (1,744 words) - 14:15, 24 April 2024
Lepodisiran (category Small interfering RNA)
Lepodisiran (LY3819469) is a small interfering RNA that was developed to reduce lipoprotein(a) in people at risk of cardiovascular disease. It was developed...
3 KB (125 words) - 03:25, 18 May 2024
Vutrisiran (category Small interfering RNA)
It is a double stranded small interfering RNA (siRNA) (also called RNA interference, or RNAi therapeutic) that interferes with the expression of the...
26 KB (2,599 words) - 15:15, 7 September 2024
RNA polymerase IV (RNAP IV) is an enzyme that synthesizes small interfering RNA (siRNA) in plants, which silence gene expression. RNAP IV belongs to a...
15 KB (1,821 words) - 09:09, 14 August 2023
mRNA into proteins. In cells of humans and other animals, miRNAs primarily act by destabilizing the mRNA. miRNAs resemble the small interfering RNAs (siRNAs)...
147 KB (16,694 words) - 11:36, 13 September 2024
A small conditional RNA (scRNA) is a small RNA molecule or complex (typically less than approximately 100 nt) engineered to interact and change conformation...
7 KB (464 words) - 15:55, 16 July 2024
Nucleic acid (redirect from DNA and RNA)
biological nucleic acid molecules range in size from 21 nucleotides (small interfering RNA) to large chromosomes (human chromosome 1 is a single molecule that...
24 KB (2,853 words) - 22:25, 28 July 2024
double-stranded RNAs that function as small interfering RNA (siRNA) in the RNA silencing system. By sequestering siRNA, p19 suppresses RNA silencing and...
11 KB (1,172 words) - 03:13, 29 January 2023
A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target...
10 KB (1,259 words) - 12:22, 22 February 2024
Zilebesiran (category Small interfering RNA)
Zilebesiran is an experimental small interfering RNA developed by Roche and Alnylam that is administered subcutaneously twice annually to lower blood...
42 KB (222 words) - 22:04, 22 August 2024
Gene silencing (category RNA)
by an enzyme called Dicer. These small fragments, which include small interfering RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides...
48 KB (5,609 words) - 06:40, 12 September 2024
and regulate RNA modification. It has been observed that small interfering RNA (siRNA) and micro RNA (miRNA) are generally used as target RNA sequences,...
30 KB (3,628 words) - 15:29, 5 August 2024
nanoparticle RNA therapeutics for nucleic acid medicines including small interfering RNA (siRNA), messenger RNA (mRNA), gene editing RNA, DNA, antisense...
18 KB (1,712 words) - 04:04, 10 July 2024
Givosiran (category Small interfering RNA)
treatment of adults with acute hepatic porphyria. Givosiran is a small interfering RNA (siRNA) directed towards delta-aminolevulinate synthase 1 (ALAS1), an...
11 KB (596 words) - 18:59, 5 July 2024
Argonaute (category RNA-binding proteins)
as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs)...
17 KB (1,964 words) - 06:39, 18 May 2024
Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional...
9 KB (1,153 words) - 05:22, 31 January 2024
for the different types of RNA are listed and explained. List of cis-regulatory RNA elements RNA: Types of RNA Non-coding RNA Gribaldo S, Brochier-Armanet...
20 KB (1,022 words) - 13:20, 22 February 2024
Patisiran (category Small interfering RNA)
is estimated to affect 50,000 people worldwide. It is the first small interfering RNA-based drug approved by the U.S. Food and Drug Administration (FDA)...
15 KB (952 words) - 06:33, 10 March 2024
Nedosiran (category Small interfering RNA)
the treatment of primary hyperoxaluria. It is an LDHA-directed small interfering RNA developed by Dicerna Pharmaceuticals. The most common side effects...
9 KB (560 words) - 03:18, 15 July 2024