TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa) is a protein that in humans is encoded by the TARDBP gene. TDP-43...
41 KB (4,641 words) - 14:41, 30 July 2024
are found in FTLD include the accumulation of tau proteins and TAR DNA-binding protein 43 (TDP-43). Mutations in the C9orf72 gene have been established...
21 KB (2,225 words) - 13:24, 17 August 2024
Motor neuron diseases (section DNA damage)
involved. TAR DNA-binding protein 43 (TDP-43), is a critical component of the non-homologous end joining (NHEJ) enzymatic pathway that repairs DNA double-strand...
21 KB (2,137 words) - 22:21, 9 July 2024
Petersen RC, et al. (July 2022). "Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of...
56 KB (6,236 words) - 03:31, 2 September 2024
pathophysiology. Abnormal TAR DNA-binding protein 43 (TDP-43) deposits were found on autopsy in the nerves of some with FOSMN. Abnormal TDP-43 deposits are seen...
9 KB (1,059 words) - 04:05, 19 February 2024
Proteinopathy (redirect from Protein misfolding)
(SOD1), polyglutamine, and TAR DNA-binding protein-43 (TDP-43). In all of these instances, an aberrant form of the protein itself appears to be the pathogenic...
62 KB (4,598 words) - 21:08, 10 September 2024
CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP...
52 KB (5,272 words) - 09:56, 3 June 2024
Neurodegenerative disease (section DNA damage)
patients with familial ALS. More recently, TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS) protein aggregates have been implicated in some...
63 KB (6,939 words) - 02:47, 2 September 2024
sclerosis and frontotemporal lobar degeneration are often TAR DNA-binding protein 43 (TDP-43) proteinopathies.: 1506 In 2009, researchers recognized that...
37 KB (2,900 words) - 04:18, 2 September 2024
"Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS)". The Journal of Biological Chemistry...
183 KB (12,458 words) - 20:40, 1 July 2024
Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded...
14 KB (1,682 words) - 04:58, 9 June 2024
smoke, soot and tar create a huge diversity of DNA adducts- ethanoates, oxidized bases, alkylated phosphodiesters and crosslinking of DNA, just to name...
129 KB (15,900 words) - 06:12, 13 August 2024
Z-DNA conformation. In motor neurons, the most well-grounded marker of amyotrophic lateral sclerosis (ALS) is the TAR DNA-binding protein (TDP-43). When...
38 KB (4,802 words) - 18:44, 25 April 2024
Martell, Jeffrey D. (2023-08-02). "Terminal Alkyne-Modified DNA Aptamers with Enhanced Protein Binding Affinities". ACS Chemical Biology. 18 (9): 1976–1984....
60 KB (6,559 words) - 14:38, 19 June 2024
Ku80 (redirect from ATP-dependent DNA helicase 2 subunit 2)
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand...
21 KB (2,612 words) - 05:45, 11 June 2024
Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert (2010-10-11). "Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells...
14 KB (1,579 words) - 21:07, 12 September 2024
protein that in humans is encoded by the PURA gene located at chromosome 5, band q31. Pur-alpha is an ancient, multi-functional DNA- and RNA-binding protein...
34 KB (4,047 words) - 17:10, 25 October 2023
DNA cross-link repair 1B DEPDC1 encoding protein DEP domain containing 1 DIRAS3 (1p31): DIRAS family, GTP-binding RAS-like 3 DISP3: encoding protein Dispatched...
46 KB (3,290 words) - 20:16, 17 August 2024
Granulin (category Protein families)
enriched in hyperphosphorylated TAR DNA-binding protein 43 (TDP-43), autophagy-related protein aggregates, ubiquitin-binding protein p62, lentiform intranuclear...
32 KB (3,334 words) - 03:20, 29 November 2023
acting by binding the TAR RNA element. The TAR may also be processed into microRNAs that regulate the apoptosis genes ERCC1 and IER3. The rev protein (p19)...
124 KB (14,119 words) - 18:13, 3 September 2024
Alice S.; Lee, Virginia M.-Y.; Trojanowski, John Q. (2010). "TAR DNA-binding protein 43 in neurodegenerative disease". Nature Reviews Neurology. 6 (4):...
18 KB (1,784 words) - 05:30, 11 July 2024
autosomal dominant mode of inheritance. TARDBP, which codes for TAR DNA-binding protein (TDP-43), is associated with 1–5% of familial ALS and less than 1%...
38 KB (3,891 words) - 20:30, 19 June 2024
crosslinking with immunoprecipitation in order to identify RNA binding sites of proteins on a transcriptome-wide scale, thereby increasing our understanding...
50 KB (4,888 words) - 11:50, 22 February 2024
Interferon (category Protein pages needing a picture)
Interferons (IFNs, /ˌɪntərˈfɪərɒn/ IN-tər-FEER-on) are a group of signaling proteins made and released by host cells in response to the presence of several...
62 KB (7,065 words) - 05:17, 28 June 2024
MicroRNA (section DNA repair and cancer)
RNA (TAR) binding protein], PACT (protein activator of the interferon-induced protein kinase), the SMN complex, fragile X mental retardation protein (FMRP)...
147 KB (16,694 words) - 11:36, 13 September 2024
Ribosomal RNA (category Protein biosynthesis)
carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small...
60 KB (7,195 words) - 13:36, 12 September 2024
expression of CK1δ is low. The AD hallmark proteins tau in NFTs or GVBs and TAR DNA-binding protein of 43 kDa (TDP-43) in GVBs colocalize with CK1δ. In vitro...
118 KB (14,740 words) - 02:59, 9 September 2024
Rolling hairpin replication (category DNA replication)
the viral initiator protein is transcribed and translated to synthesize the protein. The initiator protein commences RHR by binding to and nicking the...
54 KB (7,421 words) - 20:53, 1 February 2024
Berkhout B, Jeang KT (Mar 1991). "Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR". Science. 251 (5001): 1597–600. Bibcode:1991Sci...
11 KB (1,413 words) - 23:12, 19 November 2022