(TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1...

transforming growth factor receptor 3 (TGFβR3) is the most abundant of the TGF-β receptors yet, it has no known signaling domain. It however may serve to...

proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. TGF-β is a multifunctional set of peptides that controls proliferation...

affinity for TGFβ2. TGFβR3 (β-glycan) has a high affinity for both homodimeric TGFβ1 and TGFβ2 and in addition the heterodimer TGF-β1.2. The TGFβ receptors...

fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates...

activation of TGF-β by binding to TGF-β1 LAP, which serves as a ligand binding site for the integrin, and is an essential component of the TGF-β activation...

altered TGF-β activation and signalling. Aortic specific symptoms are closely related to excessive TGF-β signalling in the aortic root wall. TGF-β antagonism...

growth factor, either of two classes of polypeptide growth factors (TGF-α and TGF-β) Terrestrial gamma-ray flash, a burst of gamma rays produced in the...

type II and type I kinase receptors binding to the TGF-β ligands. Transforming growth factor-β (TGF-β) is a superfamily of cytokines that play a significant...

primarily located in the cytoplasm, but accumulate in the nucleus following TGF-β signaling, where they can bind to DNA and regulate transcription. However...

factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling...

Common genes implicated in fibrosis are Transforming Growth Factor-Beta (TGF-β), Connective Tissue Growth Factor (CTGF), Epidermal Growth Factor Receptor...

factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally...

domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors. TGFβR3 (β-glycan) "Prosite...

the proximal region. TGF-β is important for cell proliferation and differentiation during skeletogenesis. During this process, TGF-β can stimulate differentiation...

Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. It is a multifunctional signaling molecule with more...

Research has found that the cytokine transforming growth factor beta (TGF-β) is essential for Treg cells to differentiate from naïve CD4+ cells and...

secretion of anti-inflammatory cytokine transforming growth factor beta (TGF-β). Th3 have been described both in mice and human as CD4+FOXP3− regulatory...

gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the TGF-β signal from the cell surface to the cytoplasm...

are involved in promoting metastatic events. Several signaling pathways (TGF-β, FGF, EGF, HGF, Wnt/beta-catenin and Notch) and hypoxia may induce EMT....

Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. When the cell is treated with TGF-β, HIPK2, a nuclear kinase...

preventing the inappropriate trafficking of the receptor into the nucleus. TGF-β cytokines are members of a signaling protein family that includes activin...

Transforming growth factor beta (TGF-β) plays an important role in MFS. Fibrillin-1 directly binds a latent form of TGF-β, keeping it sequestered and unable...

that involves the deep layers of the dermis and express high levels of TGF-β.[citation needed] Mechanical tension on a wound has been identified as a...

syndrome. Biologically, SMAD4 plays a prominent role in both canonical TGF-β and other TGF-β superfamily signaling. The systemic manifestations of these two...

liver regeneration process is completed, TGF-β puts an end to the proliferation phase by inducing apoptosis. TGF-β is the most important anti-proliferative...

which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins. TGF-β3 is believed...

SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction. The TGFβ family of cytokines regulates critical processes...

Collectively, all members of the EGF/TGF-α family share this structure. The protein, however, is not directly related to TGF-β. Limited success has resulted...

extracellular TGF-β superfamily ligand signaling from cell membrane bound TGF-β receptors into the nucleus where they activate transcription TGF-β target genes...