The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of...

produces toxicity in 50% of individuals). This relationship, termed the therapeutic index, is defined as the ratio TD50:ED50. In general, the narrower this...

The protective index (PI) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity....

replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious...

molecules can be useful for many applications, such as determining the therapeutic index of a drug candidate in a clinical trial. To obtain serum, a blood...

cells while inducing less harmful systemic effects in the body. The therapeutic index (TI) is used to quantify the risks and benefits of a certain drug...

substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions...

maximum benefit without adverse effects. When a drug has a narrow therapeutic index, titration is especially important, because the range between the...

which are hallucinogenic in higher doses) characterized by a narrow therapeutic index. Some attempts to create love potions have led to overdose or death...

absorption and high peak blood concentrations of DNP to provide a wider therapeutic index and improve safety." Developed by Rivus Pharmaceuticals, the drug...

injectable colchicine from the US market. Colchicine has a narrow therapeutic index, so overdosing is a significant risk. Common side effects of colchicine...

(ED50). Therefore, it is more useful to compare such substances by therapeutic index, which is simply the ratio of LD50 to ED50. The following examples...

betamethasone or dexamethasone. The review noted that the drug has a high therapeutic index, being used at initial oral doses ranging from 6 to 90 mg, and probably...

use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy. Typically there is a 4–10 fold variation in...

or plasma exposure. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic...

some limited application in herbal medicine, although the narrow therapeutic index makes calculating appropriate dosage difficult. Aconitine is also...

pumilio (Tī rauriki, Tī koraha or Dwarf cabbage tree, New Zealand) Therapeutic index Ti (prefix symbol), of interim unit tebi; e.g. Tib for tebibit Topological...

can be used to bind to and remove DNP from solution. DNP has a low therapeutic index, meaning that the dosage at which toxicity occurs is not much larger...

chloroform as a general anesthetic due to ether's more favorable therapeutic index, that is, a greater difference between an effective dose and a potentially...

processes Median lethal dose – Measurement of lethal dose of substance Therapeutic index – Quantitative measurement of the relative safety of a drug "Die dritte...

Warfarin is highly protein-bound (>95%) and has a low therapeutic index. Since a low therapeutic index indicates that there is a high risk of toxicity when...

corms of C. autumnale contain colchicine, a useful drug with a narrow therapeutic index. Colchicine is approved in many countries for the treatment of gout...

drugs such as pemoline and thozalinone. It displayed a favorable therapeutic index and margin of safety in comparison to pemoline and other N-lower-alkyl-substituted...

to characterize toxicity include the median lethal dose (LD50) and therapeutic index. Computational chemists try to predict the ADME-Tox qualities of compounds...

in development for the treatment of chronic pain. It has a wider therapeutic index than pregabalin, which as a similar mechanism of action. It is in...

have a high therapeutic index; that is, phage therapy would be expected to give rise to few side effects, even at higher-than-therapeutic levels. Because...

the fact that they have a low therapeutic index, while melatonin agonists are shown to have a higher therapeutic index. Sleep deprivation has become hardwired...

it is not used clinically due to severe adverse effects and a low therapeutic index. Being a precursor to a series of extremely strong opioids, oripavine...

specific drug may be done for a better safety profile or an improved therapeutic index. This process is called chiral switching and the resulting enantiopure...

ciprofloxacin is cautioned in patients on theophylline due to its narrow therapeutic index. The authors of one review recommended that patients being treated...