A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions...
43 KB (5,251 words) - 10:44, 24 June 2024
the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown...
28 KB (3,078 words) - 07:46, 3 June 2024
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation...
10 KB (1,179 words) - 18:31, 8 August 2024
Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in...
22 KB (2,389 words) - 06:43, 22 April 2024
donor, such as ATP, to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that can transfer...
21 KB (2,716 words) - 15:11, 26 August 2023
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 was the first member of the JAK family that was...
25 KB (2,850 words) - 23:00, 12 November 2023
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling...
28 KB (3,166 words) - 19:57, 8 August 2024
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)...
21 KB (2,648 words) - 12:12, 26 July 2024
Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the...
19 KB (2,358 words) - 16:34, 16 July 2024
cluster region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...
29 KB (3,538 words) - 15:01, 5 December 2023
threonine, or tyrosine amino acids on the protein. Most kinases act on both serine and threonine, the tyrosine kinases act on tyrosine, and a number (dual-specificity...
23 KB (750 words) - 23:26, 13 August 2024
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...
9 KB (974 words) - 14:46, 22 June 2024
serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. Most of the others are tyrosine kinases, although...
15 KB (1,635 words) - 23:25, 13 August 2024
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded...
48 KB (5,299 words) - 01:24, 9 March 2024
tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase...
14 KB (1,695 words) - 03:57, 23 December 2023
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck...
10 KB (1,215 words) - 03:15, 19 April 2024
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases...
56 KB (6,475 words) - 07:21, 26 August 2024
Tyrosin-protein kinase Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside lymphocytes and encoded in the human...
36 KB (4,466 words) - 12:30, 11 May 2024
motifs. Ray Erikson discovered that v-Src was a kinase and Tony Hunter found that v-Src phosphorylated tyrosine residues on proteins in the 1970s. In the early...
67 KB (7,955 words) - 20:50, 29 July 2024
Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine...
8 KB (977 words) - 00:09, 6 October 2021
(disease-modifying antirheumatic drugs), and they are a subclass of tyrosine kinase inhibitors. They work by modifying the immune system via cytokine activity...
35 KB (2,984 words) - 10:45, 30 August 2024
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc)...
21 KB (2,423 words) - 03:55, 27 January 2024
protein-coupled receptors, dimerization is essential for receptor tyrosine kinases (RTK) to perform their function in signal transduction, affecting many...
13 KB (1,365 words) - 12:45, 11 July 2024
KIT (gene) (redirect from Tyrosine kinase mutation)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or...
35 KB (4,117 words) - 00:12, 6 August 2024
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor,...
40 KB (4,319 words) - 02:54, 11 August 2024
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK, along with ZAP70, is...
18 KB (2,083 words) - 06:18, 25 December 2023
DYRK1A (redirect from Dual specificity tyrosine-phosphorylation-regulated kinase 1A)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this...
12 KB (1,499 words) - 08:36, 11 July 2024
Philadelphia chromosome. CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term...
34 KB (3,877 words) - 01:25, 22 July 2024
CD135 (redirect from Fms-related tyrosine kinase 3)
like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2)...
15 KB (1,727 words) - 00:58, 25 August 2024
Epidermal growth factor receptor (category Tyrosine kinase receptors)
extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve...
60 KB (6,879 words) - 14:26, 16 July 2024