U.S. Route 40 (US 40) in the U.S. state of Maryland runs from Garrett County in Western Maryland to Cecil County in the state's northeastern corner. With...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66), is a major east–west United...

Several special routes of U.S. Route 40 exist. In order from west to east they are as follows. U.S. Route 40 Business (US-40 Bus.) is a 2.3-mile-long (3...

U.S. Route 240 is a defunct designation for a short, but once very important, segment of highway between Frederick, Maryland, and Washington, D.C. It is...

U.S. Route 40 Alternate (Alt US 40) is the U.S. Highway designation for a former segment of U.S. Route 40 (US 40) through Garrett and Allegany counties...

U.S. Route 40 Scenic (US 40 Scenic) is a scenic route of US 40 in the U.S. state of Maryland. US 40 Scenic, which is known for most of its route as National...

U.S. Route 140 (Pennsylvania "Legislative Route 42") was a U.S. highway connecting Gettysburg, Pennsylvania, to Baltimore, Maryland. The route was deleted...

U.S. Route 40 Alternate (US 40 Alternate) is an alternate route of US 40 in the U.S. state of Maryland. The highway runs 22.97 miles (36.97 km) from Potomac...

U.S. Route 340 (US 340) is a spur route of US 40, and runs from Greenville, Virginia, to Frederick, Maryland. In Virginia, it runs north–south, parallel...

U.S. Route 40 (US 40) enters Pennsylvania at West Alexander. It closely parallels Interstate 70 (I-70) from West Virginia until it reaches Washington,...

Pensacola, Florida, to the western suburbs of Baltimore, Maryland. In the U.S. state of Maryland, US 29 is a major highway that emerges from Washington DC...

until the freeway's construction was completed in 1991, it was designated as U.S. Route 48 (US 48). In Maryland, the highway is known as the National Freeway...

U.S. Route 113 (US 113) is a U.S. Highway that is a spur of US 13 in the U.S. states of Maryland and Delaware. The route runs 74.75 miles (120.30 km) from...

U.S. Route 522 (US 522) is a spur route of US 22 in the states of Virginia, West Virginia, Maryland, and Pennsylvania. The U.S. Highway travels in a north-south...

U.S. Route 222 (US 222) is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for 95 miles (153 km) from US 1...

U.S. Route 40 (US 40) is a US highway running from Silver Summit, Utah, east to Atlantic City, New Jersey. In the US state of Delaware, it serves as a...

Corner, Delaware, at Delaware Route 1 to Sarasota, Florida, at U.S. Route 41. It passes through the states of Delaware, Maryland, Virginia, North Carolina...

City, Maryland, on the Atlantic Ocean. In the U.S. state of Maryland, US 50 exists in two sections. The longer of these serves as a major route connecting...

Virginia, to West Seneca, New York. In the U.S. state of Maryland, the U.S. Highway runs 48.40 miles (77.89 km) from the West Virginia state line near...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

Carolina, Virginia, Maryland, Pennsylvania, and New York. The route is signed north–south, from US 17 Alternate (US 17 Alt.) in Walterboro, South Carolina...

intersecting at US 460. US 219 is found (from north to south) in New York, Pennsylvania, Maryland, West Virginia, and Virginia. Much of the Route in West Virginia...

Maryland Route 140 (MD 140) is a 49-mile (79 km) state highway in the U.S. state of Maryland. The route runs from U.S. Route 1 (US 1) and US 40 Truck...

Maryland Route 144 (MD 144) is a collection of state highways in the U.S. state of Maryland. These highways are sections of old alignment of U.S. Route...

U.S. Route 1 (US 1) is the easternmost and longest of the major north–south routes of the older 1920s era United States Numbered Highway System, running...

southern terminus at US 90 and US 98 in Pensacola to its northern terminus at Maryland Route 99 (MD 99) in Ellicott City. The section of US 29 between Greensboro...

U.S. Route 301 (US 301) in the state of Maryland is a major highway that runs 122.85 miles (197.71 km) from the Governor Harry W. Nice Memorial Bridge...

Maryland Route 213 (MD 213) is a 68.25-mile (109.84 km) state highway located on the Eastern Shore of Maryland in the United States. The route runs from...

in the 1950s. US 15 was relocated to part of the freeway; the old route of the U.S. Highway through downtown Frederick became part of Maryland Route 355...

from U.S. Route 1 (US 1)/US 40 Truck in Baltimore north to the Pennsylvania state line in Maryland Line, where the highway continues as State Route 3001...