• Thumbnail for Antiporter
    An antiporter (also called exchanger or counter-transporter) is an integral membrane protein that uses secondary active transport to move two or more molecules...
    61 KB (7,825 words) - 09:17, 6 October 2024
  • Thumbnail for Sodium–hydrogen antiporter
    isoforms of the antiporter: Sodium–hydrogen antiporter 1 Sodium–hydrogen antiporter 2 Sodium–hydrogen antiporter 3 Sodium–hydrogen antiporter 4 Sodium–hydrogen...
    6 KB (670 words) - 09:42, 14 May 2024
  • Thumbnail for Monovalent cation:proton antiporter-1
    The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC# 2.A.36) is a large family of proteins derived from Gram-positive and Gram-negative bacteria...
    10 KB (1,139 words) - 22:42, 29 May 2024
  • Thumbnail for Sodium–hydrogen antiporter 1
    sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that...
    13 KB (1,439 words) - 23:17, 8 December 2023
  • The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family (TC# 2.A.63) is a member of the Na+ transporting Mrp superfamily. The CPA3 family consists...
    8 KB (1,022 words) - 07:33, 16 April 2022
  • The Ca2+:H+ antiporter-2 (CaCA2) family (TC# 2.A.106) is a member of the lysine exporter (LysE) superfamily. Note that this family differs from the calcium:cation...
    5 KB (494 words) - 01:00, 24 August 2021
  • Thumbnail for Sodium–hydrogen antiporter 3
    Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans...
    11 KB (1,346 words) - 18:23, 28 January 2023
  • Thumbnail for Cotransporter
    enable coupled or cotransport (secondary active transport) and include antiporters and symporters. In general, cotransporters consist of two out of the...
    22 KB (2,288 words) - 20:18, 2 October 2023
  • substances in the direction of their respective concentration gradient. In an antiporter, one substrate is transported in one direction across the membrane while...
    31 KB (3,826 words) - 04:03, 30 September 2024
  • The Monovalent Cation:Proton Antiporter-2 (CPA2) Family (TC# 2.A.37) is a moderately large family of transporters belonging to the CPA superfamily. Members...
    16 KB (1,850 words) - 03:48, 29 November 2023
  • Thumbnail for Cystine/glutamate transporter
    transporter is an antiporter that in humans is encoded by the SLC7A11 gene. The SLC7A11 gene encodes a sodium-independent cystine-glutamate antiporter that is chloride...
    26 KB (3,381 words) - 04:21, 28 January 2024
  • Thumbnail for Malate–aspartate shuttle
    intermembrane space. malate-alpha-ketoglutarate antiporter in the inner membrane. glutamate-aspartate antiporter in the inner membrane. The primary enzyme in...
    6 KB (801 words) - 19:00, 1 September 2024
  • Thumbnail for Cocaine
    Cocaine crosses the blood–brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive diffusion across cell membranes....
    181 KB (19,613 words) - 04:19, 10 October 2024
  • Thumbnail for Loop of Henle
    which both push more Na into the cell via the Na–H antiporter. The hydrogen ion for the antiporter comes from the enzyme carbonic anhydrase, which takes...
    12 KB (1,586 words) - 23:58, 2 April 2024
  • Thumbnail for Distal convoluted tubule
    basolateral surface (peritubular capillary side) there is an ATP-dependent Na/K antiporter pump, a secondary active Na/Ca transporter, and an ATP dependent Ca transporter...
    5 KB (482 words) - 10:33, 21 August 2024
  • driving force, but initially it needs the cotransporter SGLT and the Na-H antiporter. Sodium passes along an electrochemical gradient (passive transport) from...
    6 KB (419 words) - 18:21, 22 September 2024
  • The Ca2+:cation antiporter (CaCA) family (TC# 2.A.19) is a member of the cation diffusion facilitator (CDF) superfamily. This family should not be confused...
    13 KB (1,664 words) - 04:27, 29 November 2023
  • shuttle. The malate/a-ketoglutarate antiporter functions move electrons while the aspartate/glutamate antiporter moves amino groups. This allows the mitochondria...
    5 KB (605 words) - 17:39, 7 September 2023
  • Thumbnail for Pendrin
    β-intercalated cells may use pendrin in concert with a Na+/HCO3−/2Cl− antiporter in order to resorb NaCl. Mutations in this gene are associated with Pendred...
    20 KB (2,317 words) - 03:49, 30 June 2024
  • Thumbnail for Sulfasalazine
    anti-inflammatory effects. It also appears to inhibit the cystine-glutamate antiporter, as well as sepiapterin reductase. It is a codrug which is a combination...
    17 KB (1,341 words) - 18:38, 17 March 2024
  • The ATP:ADP Antiporter (AAA) Family (TC# 2.A.12) is a member of the major facilitator superfamily. Members of the AAA family have been sequenced from bacteria...
    3 KB (369 words) - 17:27, 15 July 2024
  • Thumbnail for Transmembrane protein
    symporter (proton glutamate symporter) Monovalent cation/proton antiporter (Sodium/proton antiporter 1 NhaA) Neurotransmitter sodium symporter Ammonia transporters...
    21 KB (2,262 words) - 15:51, 18 July 2024
  • Thumbnail for Excitatory amino acid transporter 1
    Cotransporter Na+/K+,Cl− Na+/Pi3 Na+/Cl− Na+/glucose Na+/I− Cl−/K+ 4 5 Antiporter (exchanger) Na+/H+ Na+/Ca2+ Na+/(Ca2+-K+) - Cl−/HCO− 3 (Band 3) Cl−-formate...
    15 KB (1,818 words) - 22:04, 12 September 2024
  • NhaB is 58% identical to the orthologous Vibrio alginolyticus Na+/H+ antiporter. Although the latter protein is predicted to exhibit 10 TMSs, construction...
    4 KB (470 words) - 07:58, 18 August 2023
  • gradient is necessary to pump out sarcoplasmic calcium via the Na+/Ca++ antiporter. Inhibition of the Na+/K+ causes extra sodium to accumulate inside the...
    7 KB (857 words) - 07:57, 4 May 2024
  • Thumbnail for Gastric acid
    bicarbonate ions. The hydrogen ions leave the cell through H+/K+ ATPase antiporter pumps. At the same time, sodium ions are actively reabsorbed[citation...
    15 KB (1,772 words) - 22:35, 9 May 2024
  • exchanger (often denoted Na+/Ca2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that...
    20 KB (2,223 words) - 06:51, 15 July 2024
  • Thumbnail for Gastrointestinal tract
    imbalanced ratio results in dysbiosis. Enzymes such as CYP3A4, along with the antiporter activities, are also instrumental in the intestine's role of drug metabolism...
    49 KB (5,810 words) - 22:38, 3 October 2024
  • Thumbnail for NhaA family
    Na+/H+ antiporter A (NhaA) family (TC# 2.A.33) contains a number of bacterial sodium-proton antiporter (SPAP) proteins. These are integral membrane proteins...
    9 KB (1,111 words) - 18:39, 24 September 2024
  • Thumbnail for Dent's disease
    CLCN5 gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the OCRL1 gene (Dent 2). Dent's...
    12 KB (1,239 words) - 17:28, 19 September 2024