Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens...
27 KB (3,036 words) - 07:29, 5 October 2024
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, and gynecomastia in men. They...
21 KB (2,055 words) - 21:02, 29 September 2024
Aromatase deficiency is a rare condition characterized by extremely low levels or complete absence of the enzyme aromatase activity in the body. It is...
19 KB (1,681 words) - 14:03, 18 June 2024
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase...
16 KB (1,551 words) - 19:09, 22 July 2024
Medications such as aromatase inhibitors have been found to be effective and even in rare cases of gynecomastia from disorders such as aromatase excess syndrome...
63 KB (6,551 words) - 04:35, 6 October 2024
Cancer (redirect from Cancer aromatase)
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign...
186 KB (20,063 words) - 13:32, 14 October 2024
ovary. There is a curious resemblance of the increased aromatase activity in chickens, to the aromatase excess syndrome in humans, a rather rare syndrome that...
10 KB (1,434 words) - 09:27, 5 December 2021
Exemestane (category Aromatase inhibitors)
breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers...
19 KB (1,832 words) - 12:55, 3 August 2024
Letrozole (category Aromatase inhibitors)
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer. It was...
20 KB (1,820 words) - 16:01, 16 October 2024
Non-Steroidal Aromatase Inhibitors (NSAIs) are one of two categories of aromatase inhibitors (AIs). AIs are divided into two categories, steroidal aromatase inhibitors...
31 KB (3,675 words) - 04:23, 27 September 2023
2000s, there were clinical trials exploring the effectiveness of the aromatase inhibitor letrozole for infertility treatment.[needs update] Besides,...
39 KB (4,127 words) - 23:26, 21 July 2024
androstenedione, by the enzyme aromatase. Minor endogenous estrogens, the biosyntheses of which do not involve aromatase, include 27-hydroxycholesterol...
73 KB (7,786 words) - 16:26, 11 October 2024
treatment of breast cancer, although another class of hormonal agents, aromatase inhibitors, now have an expanding role in that disease. One effective...
12 KB (1,363 words) - 20:23, 16 August 2024
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in...
24 KB (2,713 words) - 03:31, 27 December 2023
Anastrozole (category Aromatase inhibitors)
osteoporosis. Use during pregnancy may harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the production...
27 KB (2,332 words) - 04:27, 27 February 2024
Fertility medication (section Aromatase inhibitors)
breast cancer treatment, aromatase inhibitors (particularly generic letrozole) are also used in ovulation induction. Aromatase inhibitors are a common...
23 KB (2,599 words) - 01:55, 14 April 2024
Hyperestrogenism can be caused by ovarian tumors, genetic conditions such as aromatase excess syndrome (also known as familial hyperestrogenism), or overconsumption...
5 KB (389 words) - 18:15, 25 June 2022
aromatase inhibitors and antigonadotropins can be considered antiestrogens by some definitions, they are often treated as distinct classes. Aromatase...
8 KB (745 words) - 06:15, 3 September 2024
Antihormone therapy (section Aromatase inhibitors)
called aromatase inhibitors are commonly prescribed to postmenopausal women who test positive for hormone receptor-positive cancer. Aromatase in fat and...
11 KB (1,058 words) - 15:08, 21 July 2024
cluster of neurons that comprise the oSDN express cytochrome P450 aromatase. Aromatase mRNA levels in the oSDN were significantly greater in female-oriented...
18 KB (1,904 words) - 14:30, 16 September 2024
the demethylation of some sterols. These conversions are catalyzed by aromatase enzymes using O2 as the oxidant. Specific conversions include testosterone...
6 KB (528 words) - 14:19, 3 September 2024
involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol. Alternatively...
75 KB (7,245 words) - 18:06, 26 August 2024
Anabolic steroid (section Aromatase and estrogenicity)
from 5α-reductase, aromatase may inactivate testosterone signaling in skeletal muscle and adipose tissue, so AAS that lack aromatase affinity, in addition...
209 KB (21,568 words) - 16:45, 2 October 2024
standishinal which has shown relatively potent effects on the enzyme aromatase. It acts as an inhibitor, thus decreasing the synthesis of estradiol in...
3 KB (332 words) - 18:30, 25 January 2024
tissue, or aromatase inhibitors, such as anastrozole. ER status is used to determine sensitivity of breast cancer lesions to tamoxifen and aromatase inhibitors...
35 KB (3,818 words) - 10:04, 26 August 2024
testosterone or an aromatase inhibitor is administered, indicating that the enzyme responsible for conversion of testosterone to estradiol, aromatase, plays a role...
33 KB (3,823 words) - 20:27, 2 September 2024
also be converted to estradiol (E2) by the aromatase enzyme, which may lead to gynecomastia in males. Aromatase inhibitors, such as anastrozole, letrozole...
26 KB (2,246 words) - 18:23, 12 October 2024
is only really commonly used in men. Metandienone is a substrate for aromatase and can be metabolized into the estrogen methylestradiol (17α-methylestradiol)...
27 KB (2,274 words) - 02:54, 22 March 2024
and gynecomastia in men. Aromatase inhibitors like exemestane (which forms a permanent and deactivating bond with the aromatase enzyme) and anastrozole...
11 KB (1,115 words) - 00:38, 16 July 2024
adipose-derived stem cells. Adipose tissue is a major peripheral source of aromatase in both males and females, contributing to the production of estradiol...
73 KB (8,510 words) - 13:02, 12 October 2024