chemists as chiral or handed molecules. Each twin is called an enantiomer. Drugs that exhibit handedness are referred to as chiral drugs. Chiral drugs that are...
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Enantiomer (redirect from Chiral amplification)
improved therapeutic efficacy. The switch from a racemic drug to an enantiopure drug is called a chiral switch. In many cases, the enantiomers have distinct...
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Chirality (/kaɪˈrælɪti/) is a property of asymmetry important in several branches of science. The word chirality is derived from the Greek χείρ (kheir)...
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In chemistry, a molecule or ion is called chiral (/ˈkaɪrəl/) if it cannot be superposed on its mirror image by any combination of rotations, translations...
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one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. Chirality can be observed...
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enantiomers from racemate drugs. For example, levofloxacin is a chiral switch of racemic ofloxacin. The essential principle of a chiral switch is that there...
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of drugs (oxazepam, lorazepam, temazepam), thalidomide, and tiaprofenic acid. A brief list of select pharmaceutical drugs that go through chiral inversion...
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optically active compounds, including drugs. Another term with the same meaning is optical resolution. The use of chiral resolution to obtain enantiomerically...
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enantioselective analysis. Chiral analysis includes all analytical procedures focused on the characterization of the properties of chiral drugs. Chiral analysis is usually...
63 KB (6,792 words) - 22:07, 2 December 2023
Chiral column chromatography is a variant of column chromatography that is employed for the separation of chiral compounds, i.e. enantiomers, in mixtures...
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Fenoprofen (category Drugs with non-standard legal status)
Limited) Ibuprofen Ketoprofen Thalidomide Chirality Chiral drugs Chiral inversion "FDA-sourced list of all drugs with black box warnings (Use Download Full...
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common from around 1960, distinguishes these drugs from corticosteroids, another class of anti-inflammatory drugs, which during the 1950s had acquired a bad...
111 KB (11,573 words) - 22:42, 11 October 2024
Pregabalin (category Drugs with non-standard legal status)
PMID 10189176. S2CID 38496241. Lin GQ, You QD, Cheng JF, eds. (August 8, 2011). Chiral Drugs: Chemistry and Biological Action. John Wiley & Sons. p. 88. ISBN 9781118075630...
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In stereochemistry, a chiral auxiliary is a stereogenic group or unit that is temporarily incorporated into an organic compound in order to control the...
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Enantioselective synthesis (redirect from Chiral ligand)
reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric...
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Chemical structures of the catecholamines Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic...
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Inc. p. 172. Nguyen, Lien Ai; He, Hua; Pham-Huy, Chuong (2016-11-20). "Chiral Drugs: An Overview". International Journal of Biomedical Science. 2 (2): 85–100...
26 KB (2,550 words) - 22:06, 25 September 2024
Levofloxacin (category Drugs with non-standard legal status)
OCLC 1097808137. Agranat I, Caner H (July 1999). "Intellectual property and chirality of drugs". Drug Discovery Today. 4 (7): 313–321. doi:10.1016/s1359-6446(99)01363-x...
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Thalidomide (category Chirality)
Skálová L, Szotáková B (December 2004). "Chiral inversion of drugs: coincidence or principle?". Current Drug Metabolism. 5 (6): 517–533. doi:10.2174/1389200043335360...
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The chiral pool is a "collection of abundant enantiopure building blocks provided by nature" used in synthesis. In other words, a chiral pool would be...
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Homochirality (redirect from Chiral transmission)
patient. Many drugs are available as both a racemic mixture (equal amounts of both chiralities) and an enantiopure drug (only one chirality). Depending...
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Ethambutol (category Drugs with non-standard legal status)
tissues and fluids. 50% is excreted unchanged in urine. Chiral drugs Chirality Enantiopure drug Stereochemistry Hamilton R (2015). Tarascon Pocket Pharmacopoeia...
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and the way a drug works depends on what kind of enantiomer it is. Many drugs are chiral and it is important that the shape of the drug matches the shape...
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is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt. Racemic mixtures are rare in nature, but many compounds...
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Dexibuprofen (category Drugs with no legal status)
unaffected. Chiral switch Enantiopure drug Chirality Eudysmic ratio Ibuprofen Hardikar MS (September 2008). "Chiral non-steroidal anti-inflammatory drugs--a review"...
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Ibuprofen (redirect from Burana (drug))
doi:10.1016/0006-2952(88)90762-9. PMID 3276314. Simonyi M (1984). "On chiral drug action". Medicinal Research Reviews. 4 (3): 359–413. doi:10.1002/med...
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Synthetic cannabinoids (redirect from Cannabinoid designer drugs)
controls synthetic cannabinoids by analog under the Misuse of Drugs Act, 1971 as Class B drugs. Until 2016, synthetic cannabinoids were legally sold in head...
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classes of drugs are suspected to be particularly problematic because of their chemistry. Some of these include chiral drugs, poorly absorbed drugs, and cytotoxic...
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MDMA (redirect from Ecstacy (drug))
failure. A number of drug interactions can occur between MDMA and other drugs, including serotonergic drugs. MDMA also interacts with drugs which inhibit CYP450...
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in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active...
10 KB (1,250 words) - 23:17, 22 March 2024