Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded...
22 KB (2,658 words) - 06:17, 17 August 2024
Hydroxylation (redirect from Hydroxylase)
into dopamine. 17α-Hydroxylase Cholesterol 7 alpha-hydroxylase Dopamine β-hydroxylase Phenylalanine hydroxylase Tyrosine hydroxylase One example of non-biological...
9 KB (1,058 words) - 07:42, 20 June 2024
respectively. Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why...
10 KB (785 words) - 12:04, 13 May 2024
similar to human prostacyclin synthase (CYP8) and 31% similar to cholesterol 7 alpha-hydroxylase (CYP7). This enzymatic activity is now known to be performed...
4 KB (418 words) - 12:48, 26 August 2023
down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and...
10 KB (1,091 words) - 01:21, 17 August 2024
nucleus by the enzyme cholesterol 7 alpha-hydroxylase. This enzyme is down-regulated by cholic acid, up-regulated by cholesterol and is inhibited by the...
36 KB (4,587 words) - 11:12, 7 July 2024
Boyd GS (1971). "The oxidation of cholesterol in rat liver sub-cellular particles The cholesterol-7-alpha-Hydroxylase enzyme system". Eur. J. Biochem....
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phloroglucinol. In an animal model, THAP was reported to enhance cholesterol 7 alpha-hydroxylase (CYP7A1) activity. THAP is also used as a matrix in matrix-assisted...
3 KB (168 words) - 02:11, 1 July 2022
27-triol + NADP+ + H2O 25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450). cholesterol; 25-hydroxycholesterol. Toll A, Wikvall K, Sudjana-Sugiaman...
3 KB (274 words) - 14:14, 27 November 2023
D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a...
13 KB (1,499 words) - 16:32, 11 August 2024
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is a genetic disorder characterized by impaired production of cortisol in the adrenal...
177 KB (20,565 words) - 03:31, 20 August 2024
is the suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis from cholesterol. FXR does not directly...
17 KB (1,945 words) - 06:08, 25 July 2024
inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase". Arch. Biochem. Biophys. 311 (2):...
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the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP". Genes & Development. 7 (10): 1871–84. doi:10.1101/gad.7.10.1871...
2 KB (213 words) - 18:06, 12 February 2023
Steroid 21-hydroxylase is a protein that in humans is encoded by the CYP21A2 gene. The protein is an enzyme that hydroxylates steroids at the C21 position...
50 KB (5,615 words) - 20:02, 8 August 2024
7α-Hydroxy-4-cholesten-3-one (redirect from 7 alpha-hydroxy-4-cholesten-3-one)
bile acids from cholesterol. Its precursor, 7α-hydroxycholesterol, is produced from cholesterol by hepatic cholesterol 7α-hydroxylase (CYP7A1). It is...
4 KB (365 words) - 22:44, 17 December 2023
hydroxylases, also termed cytochrome P450 ω-hydroxylases, CYP450 omega hydroxylases, CYP450 ω-hydroxylases, CYP omega hydroxylase, CYP ω-hydroxylases...
14 KB (1,685 words) - 02:13, 17 June 2024
receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene...
14 KB (1,641 words) - 03:02, 20 June 2024
Late onset congenital adrenal hyperplasia (category Cholesterol and steroid metabolism disorders)
Noaimi AA, Saleh BO, Anbar ZN (December 2009). "The frequency of 21-alpha hydroxylase enzyme deficiency and related sex hormones in Iraqi healthy male subjects...
43 KB (4,688 words) - 16:42, 1 August 2024
(ACTH). The cells of the zona glomerulosa do not express 11β-hydroxylase and 17α-hydroxylase. This is the reason zona glomerulosa cannot synthesize cortisol...
13 KB (1,476 words) - 20:50, 17 July 2024
receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene". Mol. Endocrinol. 18 (10): 2424–39. doi:10.1210/me.2004-0009...
11 KB (1,103 words) - 22:24, 27 March 2024
3-Ketosteroid 9alpha-monooxygenase (redirect from 3-ketosteroid 9alpha-hydroxylase)
(April 2009). "Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis"...
2 KB (235 words) - 16:55, 26 August 2023
CYP2R1 (redirect from Cholecalciferol 25-hydroxylase)
cholesterol, steroids and other lipids. CYP2R1 is present in the endoplasmic reticulum of the liver (the microsomal fraction). It has 25-hydroxylase activity...
9 KB (1,133 words) - 14:06, 24 January 2024
25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1...
9 KB (1,147 words) - 04:52, 15 December 2023
genes coding for steroidogenic enzymes, especially P450scc, steroid 11β-hydroxylase, and their associated electron transfer proteins. This effect is observed...
18 KB (1,840 words) - 03:17, 26 August 2024
Cholecalciferol (redirect from Activated 7-dehydrocholesterol)
ingested. Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by parathyroid hormone and...
41 KB (4,143 words) - 05:59, 12 August 2024
26-hydroxylase, sterol 27-hydroxylase, sterol 26-hydroxylase, cholesterol 27-hydroxylase, CYP27A, CYP27A1, and cytochrome P450 27A1'. This enzyme participates...
4 KB (464 words) - 18:56, 26 August 2023
endogenous steroids and steroid hormones. They may inhibit the production of cholesterol and other sterols, sex steroids such as androgens, estrogens, and progestogens...
37 KB (2,107 words) - 17:27, 8 June 2024
17α-Hydroxyprogesterone (redirect from 17-alpha-hydroxyprogesterone)
PMC 3509141. PMID 23209664. Kim SM, Rhee JH (2015). "A case of 17 alpha-hydroxylase deficiency". Clinical and Experimental Reproductive Medicine. 42 (2)...
14 KB (1,126 words) - 10:08, 7 July 2024
Ketoconazole (category Cholesterol side-chain cleavage enzyme inhibitors)
which converts cholesterol to pregnenolone, 17α-hydroxylase and 17,20-lyase, which convert pregnenolone into androgens, and 11β-hydroxylase, which converts...
50 KB (4,376 words) - 15:14, 13 May 2024