Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism...
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foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur...
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Hepatotoxicity (redirect from Drug induced liver disease)
and vinyl chloride. Drugs continue to be taken off the market due to late discovery of hepatotoxicity. Due to its unique metabolism and close relationship...
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First pass effect (redirect from First pass metabolism)
pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which...
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of drug metabolism and as a factor contributing to multidrug resistance in infectious diseases and cancer chemotherapy. The actions of some drugs as substrates...
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effect or expected/normal responses (especially based on drug metabolism). Abnormal drug metabolism may be due to inherited factors of either Phase I oxidation...
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Detoxification (redirect from Metabolic detoxication, drug)
are particularly well-studied as part of drug metabolism, as they influence the pharmacokinetics of a drug in the body. Certain approaches in alternative...
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Drug Metabolism and Disposition is a peer-reviewed scientific journal covering the fields of pharmacology and toxicology. It was established in 1973 and...
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ways of drug administration). Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters...
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and illicit drugs, extensive food-drug and drug-drug interactions as well as ADMET (absorption, distribution, metabolism, excretion and toxicity) parameters...
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Metabolism (/məˈtæbəlɪzəm/, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main functions...
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Established in 1972, Drug Metabolism Reviews is an academic journal that publishes review articles on all aspects of drug metabolism research. It is the...
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Enteral administration (section First pass metabolism)
the route of drug administration is important because it affects drug metabolism, drug clearance, and thus dosage. The term is from Greek enteros 'intestine'...
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a drug when they can tolerate its adverse effects. Some instances of drug intolerance are known to result from genetic variations in drug metabolism. Drugs...
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Current Drug Metabolism is a peer-reviewed medical journal covering the study of drug metabolism. It was established in 2000 and is published 10 times...
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Cytochrome P450 (individual enzymes) (category Metabolism)
P450s are the major enzymes involved in drug metabolism, accounting for about 75% of the total metabolism. Most drugs undergo deactivation by P450s, either...
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enzymes. Several other members of this family are also involved in drug metabolism, but CYP3A4 is the most common and the most versatile one. Like all...
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Pharmacology (redirect from Drug science)
predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Pharmacometabolomics can...
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enzyme protein. The enzyme is involved in the metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids...
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5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions". Current Drug Metabolism. 11 (8): 659–666. doi:10...
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contrary, gut microbiota may also alter the metabolism of the drugs by modulating the host drug metabolism. This mechanism can be mediated by microbial...
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Antifungal (redirect from Anti-fungal drug)
PMID 26361585. Docampo R, Moreno SN (1990). "The metabolism and mode of action of gentian violet". Drug Metabolism Reviews. 22 (2–3): 161–78. doi:10.3109/03602539009041083...
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ADME (section Metabolism)
majority of small-molecule drug metabolism is carried out in the liver by redox enzymes, termed cytochrome P450 enzymes. As metabolism occurs, the initial (parent)...
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Bioavailability (redirect from Drug bioavailability)
absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve...
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S. Joshua Swamidass (section Drug Metabolism)
context of chemical biology and medicine. He has also worked on drug discovery, drug metabolism, and translational research. Swamidass is the founder of "Peaceful...
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CYP1A1 (section Metabolism of xenobiotics and drugs)
superfamily of enzymes. CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by hesperetin...
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organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins". Drug Metabolism and Drug Interactions. 17 (1–4): 3–22. doi:10.1515/DMDI.2000.17.1-4.3. PMID 11201301...
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Hepatocyte (section Carbohydrate metabolism)
suspension or culture to explore mechanisms of drug metabolism and even predict in vivo drug metabolism. For these purposes, hepatocytes are usually isolated...
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Aldehyde oxidase (section Role in drug metabolism)
(MAO) intermediate products. AO plays an important role in the metabolism of several drugs. AO catalyzes the conversion of an aldehyde in the presence of...
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Hepatic portal system (section Drug metabolism)
from the spleen, pancreas and visceral fat. The benefit of first-pass metabolism, whereby substances absorbed from food in the gut pass through the liver...
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