Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino...

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene...

GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with headquarters in...

The GSK China scandal in 2013 resulted from bribes made by GSK China, a division of multinational pharmaceutical company GlaxoSmithKline (GSK), to Chinese...

NP031112) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. Tideglusib has been evaluated in clinical trials for: Alzheimer's...

storage. Glycogen synthase is directly regulated by glycogen synthase kinase 3 (GSK-3), AMPK, protein kinase A (PKA), and casein kinase 2 (CK2). Each of these...

GlaxoSmithKline (GSK) Pakistan is a Pakistani pharmaceutical company which is a subsidiary of British company GSK. It is the largest pharmaceutical company...

mice produces mania like-behavior. Targets of various treatments such as GSK-3, and ERK1 have also demonstrated mania like behavior in preclinical models...

Sanofi–GSK COVID-19 vaccine sold under the brand name VidPrevtyn Beta, is a COVID-19 vaccine developed by Sanofi Pasteur and GSK. The Sanofi–GSK COVID‑19...

protected from degradation by GSK-3. Beta-catenin acts as a co-factor that alters the activity of the transcription factor tcf-3 from repressing to activating...

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene. The protein encoded by this intronless gene belongs to the GSK-3-binding...

CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3. It has proved useful for applications in molecular biology involving the...

phosphorylation of protein kinase B (PKB/Akt) and glycogen synthase kinase 3 (GSK-3). It has also been shown inhibit tyrosine phosphatase (PTPase), PTPases[clarification...

evolution of GSK-3 isozymes. Eldar-Finkelman is a leading figure in developing novel substrate competitive inhibitors (SCIs) for GSK-3 with significant...

Alzheimer's is the hyperphosphorylation of the tau protein by the enzyme GSK-3, which leads to the overproduction of amyloid peptides that cause cell death...

of rapamycin (mTOR) pathway, deactivation of glycogen synthase kinase 3 (GSK-3), and inhibition of the phosphorylation of the eukaryotic elongation factor...

pp. 141–69. ISBN 978-981-4463-92-8. Doble BW, Woodgett JR (April 2003). "GSK-3: tricks of the trade for a multi-tasking kinase". Journal of Cell Science...

glycogen synthase kinase 3 (GSK-3). GSK-3 is responsible for phosphorylating (and thus deactivating) glycogen synthase. When GSK-3 is phosphorylated, it...

water content. Mediates enzyme inhibition Phosphorylation of the enzyme GSK-3 by AKT (Protein kinase B) as part of the insulin signaling pathway. Phosphorylation...

pharmaceutical entrepreneur, best known for his research on 5-HT receptors, and GSK-3 inhibitors. He is an author of a book Drug Design for Neuroscience. He has...

counter medicines with a 7.3 percent market share in 2022. Haleon was established on 18 July 2022 as a corporate spin-off from GSK. Sir David Lewis is chairman...

000 amino acid residues in length. The exception is the small cardiac novex-3 isoform, which is only 5,604 amino acid residues in length. The following...

D2 receptor signaling may mediate protein kinase B, arrestin beta 2, and GSK-3 activity, and inhibition of these proteins results in stunting of the hyperlocomotion...

transporter 4 (GLUT4) to the plasma membrane. Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which results in increase...

that might regulate GSK-3: GBP (GSK-3 Binding Protein) and Dishevelled. The current model is that these act together to inhibit GSK-3 activity. Dishevelled...

encoded by the FRAT1 gene. The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis...

phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), a key enzyme in cholesterol synthesis. HMGR converts 3-hydroxy-3-methylglutaryl-CoA...

are linked to increased susceptibility. AXIN1 GSK-3 Management of hair loss Wingless localisation element 3 (WLE3) WNT1-inducible-signaling pathway protein...

the blastopore lip, which in turn initiates gastrulation. Inhibition of GSK-3 translation by injection of antisense mRNA may cause a second blastopore...

supplements with two inhibitory drugs ("2i"), the MEK inhibitor PD03259010 and GSK-3 inhibitor CHIR99021. ESCs divide very frequently due to a shortened G1 phase...