domain protein 4 is a protein that in humans is encoded by the MBD4 gene. Human MBD4 protein has 580 amino acids with a methyl-CpG-binding domain at...
18 KB (2,301 words) - 10:35, 24 December 2023
Base excision repair (section MBD4)
summarized below. MBD4 (methyl-CpG-binding domain protein 4) is a glycosylase employed in an initial step of base excision repair. MBD4 protein binds preferentially...
29 KB (3,493 words) - 23:41, 26 October 2024
DNA glycosylase (section MBD4)
dealt with by UNG. MBD4 is thought to correct T:G mismatches that arise from deamination of 5-methylcytosine to thymine in CpG sites. MBD4 mutant mice develop...
34 KB (4,056 words) - 12:54, 29 October 2024
specific TF according to literature or domain structure – No motif [511] MBD4 ENSG00000129071 MBD Likely sequence specific TF according to literature or...
374 KB (81 words) - 02:10, 23 September 2023
(SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are then repaired by base excision repair (BER)...
51 KB (5,481 words) - 20:28, 15 August 2024
(SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are then repaired by base excision repair (BER)...
70 KB (8,489 words) - 08:42, 7 October 2024
consequently, to transcriptional repression. The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, and in cases of MeCP2, MBD1 and MBD2, preferentially...
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converted to thymine (Thy). 5hmU can be cleaved by TDG, SMUG1, NEIL1, or MBD4. AP sites and T:G mismatches are then repaired by base excision repair (BER)...
49 KB (5,387 words) - 17:07, 6 April 2024
(SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are then repaired by base excision repair (BER)...
52 KB (6,235 words) - 15:49, 26 April 2024
Also, 5mC can be converted to thymine (Thy). 5hmU can be cleaved by TDG, MBD4, NEIL1 or SMUG1. AP sites and T:G mismatches are then repaired by base excision...
42 KB (5,158 words) - 15:54, 31 October 2024
transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4". Dev. Biol. 325 (1): 225–37. doi:10.1016/j.ydbio.2008.10.020. PMC 2645042...
8 KB (897 words) - 01:29, 12 November 2023
(SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are then repaired by base excision repair (BER)...
25 KB (2,763 words) - 21:16, 13 April 2024
(SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are then repaired by base excision repair (BER)...
40 KB (4,790 words) - 11:12, 24 March 2024
role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of...
12 KB (1,442 words) - 19:46, 3 March 2023
A6NE82 9311 MBD3L4 HGNC:37206 A6NDZ8 9312 MBD3L5 HGNC:37204 A6NJ08 9313 MBD4 HGNC:6919 O95243 9314 MBD5 HGNC:20444 Q9P267 9315 MBD6 HGNC:20445 Q96DN6...
277 KB (17 words) - 18:41, 6 October 2024
MLH1 has been shown to interact with: Bloom syndrome protein Exonuclease 1, MBD4, MSH4, Myc, and PMS2. Mismatch repair#MutH: an endonuclease present in E...
28 KB (3,414 words) - 07:04, 8 October 2024
role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of...
10 KB (1,240 words) - 11:20, 4 March 2023
Gu Z, Suzuki H, Horii A (2006). "RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression". Biochem. Biophys. Res. Commun. 351...
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mispairing frequency suggesting that other enzymes, like the functional homologue MBD4, may provide functional redundancy. This gene may have a pseudogene in the...
12 KB (1,613 words) - 21:58, 28 July 2024
role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of...
12 KB (1,402 words) - 07:11, 20 May 2024
with Fas receptor,: ABCA1, ATG5, C-FLIP, MKRN1, Casein Kinase 1a, DEDD, MBD4 MyD88, NACA, PEA15, RIPK1, RIPK3, TRADD, TRAIL, procaspase 10, and Procaspase...
34 KB (4,191 words) - 16:39, 21 December 2023
doubledstranded DNA. Other DNA glycosylases linked to U removal are UNG, TDG and MBD4. Uracil-DNA repair is essential to protect against mutations. Current evidence...
17 KB (2,225 words) - 21:45, 28 July 2024
Clarke, A. R.; Bird, A (2002). "Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice". Science. 297 (5580): 403–5. Bibcode:2002Sci...297..403M...
9 KB (705 words) - 14:06, 7 October 2024