The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several...
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a congenital mutation in the chromosome 13 gene 13q14 (retinoblastoma protein). Retinoblastoma is the most intrusive intraocular cancer among children...
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Tumor suppressor gene (redirect from Tumor suppressor protein)
the retinoblastoma tumor suppressor protein. Alfred Knudson, a pediatrician and cancer geneticist, proposed that in order to develop retinoblastoma, two...
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initiation. Another dimer present during mid G1 is composed of retinoblastoma protein (pRB) and transcription factor E2F. When pRb is bound to E2F, E2F...
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play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells...
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Pocket protein family consists of three proteins: RB – Retinoblastoma protein p107 – Retinoblastoma-like protein 1 p130 – Retinoblastoma-like protein 2 They...
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Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded by this gene is similar...
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Cell cycle (redirect from Cell cycle protein)
Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the retinoblastoma susceptibility protein (Rb) to pRb. The un-phosphorylated Rb tumour suppressor...
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Retinoblastoma, a childhood cancer of the eyes caused by a mutation in the retinoblastoma protein Retinoblastoma protein, a tumor suppressor protein Rubidium...
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Oncovirus (redirect from Viral oncogene protein)
in investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research...
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Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with: BRCA1...
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gene. Additionally, the sonic hedgehog protein has been shown to block activity of the retinoblastoma protein, thereby inducing cell cycle re-entry and...
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Human papillomavirus infection (section E6/E7 proteins)
upregulates the p21 protein, which blocks the formation of the cyclin D/Cdk4 complex, thereby preventing the phosphorylation of retinoblastoma protein (RB), and...
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Methyltransferase (section Protein regulation)
methylated protein and SAH. Known targets of these methyltransferases in humans include RCC-1 (a regulator of nuclear transport proteins) and Retinoblastoma protein...
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Cyclin D1 (section Protein structure)
myeloid). Cyclin D1 is composed of the following protein domains and motifs: retinoblastoma protein (pRb) binding motif; cyclin box domain for cyclin-dependent...
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Cyclin E/Cdk2 (section Retinoblastoma protein)
control cetrosome duplication during early S phase. The retinoblastoma tumor suppressor protein (Rb) plays a key regulatory role in several cellular activities...
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encodes the tumor suppressor retinoblastoma protein, can be detected by cytogenetic analysis in many cases of retinoblastoma. Mutations of the RB1 locus...
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enzymes are responsible for phosphorylating and thus deactivating the retinoblastoma protein, which plays a role in cell cycle progression from the G1 (first...
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Nuclear receptor co-repressor 2, P53, RPL11, Retinoblastoma protein, Retinoic acid receptor alpha, SIN3A, SKI protein, STAT3, Serum response factor and Small...
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give an overview of how these proteins modulate host cell processes. The MC007 protein sequesters retinoblastoma protein (pRb) on the mitochondria membrane...
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cancer cells, and they act by targeting tumor suppressor proteins, such as retinoblastoma protein. The LT antigen possesses a helicase motif needed for virus...
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to hyper-phosphorylation and the subsequent destabilization of retinoblastoma protein (Rb). Hypo-phosphorylated Rb, is normally bound to transcription...
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In viral status, MCV large tumor antigen (LT antigen) and retinoblastoma protein (RB protein) expression correlates with more favorable prognosis, while...
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ABL (gene) (redirect from Abelson leukemia virus protein)
Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell...
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SWI/SNF (section SWIB/MDM2 protein domain)
Guha S, Khavari PA, Alin K, Luban J, et al. (October 1994). "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest"...
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protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which...
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P53 (redirect from Protein P53)
et al. (June 1999). "Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein". Investigative Ophthalmology & Visual Science. 40 (7): 1343–50...
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Aryl hydrocarbon receptor (category PAS-domain-containing proteins)
"A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle". The Journal of Biological...
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of the retinoblastoma protein. Bioessays. 1999 Nov;21(11):950-8. Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires...
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leukemia protein, RAD9A, RBBP4, RBBP7, RCOR1, RELA, RFC1, Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, SAP30...
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