member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is...
27 KB (3,248 words) - 19:33, 4 January 2024
has a molecular cousin, TRPM8. Unlike TRPV1, TRPM8 produces cooling sensations as mentioned previously. Similar to TRPV1, TRPM8 responds to a certain chemical...
10 KB (1,263 words) - 06:25, 2 January 2024
(AG-3-5) is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Although structurally not related to menthol, it produces...
5 KB (255 words) - 01:39, 2 February 2024
activator of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol. It is slightly less potent as a TRPM8 activator...
3 KB (281 words) - 12:45, 5 March 2024
broad needles. Menthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation...
30 KB (2,865 words) - 21:48, 2 May 2024
descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is...
32 KB (2,495 words) - 18:21, 11 June 2024
pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor...
17 KB (1,516 words) - 21:00, 12 May 2024
tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8. Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal...
7 KB (814 words) - 20:35, 20 June 2023
RQ-00203078 is a drug which acts as a potent and selective blocker of the TRPM8 ion channel, which is the main receptor responsible for the sensation of...
3 KB (182 words) - 11:04, 31 October 2023
essential oils and it is a natural insect repellent. It also generates a TRPM8-mediated cooling sensation similar to menthol. Laevo-borneol is used in...
10 KB (744 words) - 01:39, 25 December 2023
brain. It is a potent inhibitor of TRPM8, similar to BCTC. Structural analysis of catharanthine shows activity on TRPM8, TRPA1, and butyrylcholinesterase...
5 KB (353 words) - 04:58, 30 April 2023
PF-05105679 is a drug which acts as a potent and selective blocker of the TRPM8 ion channel, which is the main receptor responsible for the sensation of...
3 KB (227 words) - 12:49, 12 August 2023
AMG-333 is a drug which acts as a potent and selective blocker of the TRPM8 ion channel, which is the main receptor responsible for the sensation of cold...
2 KB (108 words) - 21:21, 8 February 2024
and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers"...
16 KB (1,417 words) - 20:17, 28 May 2024
also become known for their cold-sensing mechanisms, such is the case with TRPM8. Comparative studies have shown that the functional domains and critical...
49 KB (5,513 words) - 11:56, 3 July 2024
there are papers showing it being an inhibitor of PC-PLC, COX-1, COX-2, TRPM8, TRPV1, FAAH, NAAA, MGL, and DGLα, and an inhibitor of anandamide transport...
15 KB (1,623 words) - 23:19, 24 March 2024
shampoos, soaps, and skin care products. Menthol activates cold-sensitive TRPM8 receptors in the skin and mucosal tissues, and is the primary source of...
36 KB (3,211 words) - 20:38, 19 March 2024
Umbellulone (section TRPM8)
member 8 (TRPM8) is an ion channel that is able to induce an intensely cold sensation when activated. Menthol is the primary ligand of TRPM8, but since...
12 KB (1,208 words) - 20:59, 14 November 2023
at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors, and an antagonist of TRPM8. 5-Benzyloxytryptamine is illegal in Singapore. 5-Carboxamidotryptamine...
4 KB (255 words) - 17:22, 12 June 2024
camphor. Caused by activation of the same mechanism that signals cold, TRPM8 ion channels on nerve cells, unlike the actual change in temperature described...
94 KB (10,381 words) - 20:06, 2 July 2024
immune-related signaling via transient receptor potential channels (e.g., TRPV1 and TRPM8), there is currently limited evidence to suggest that CBN acts in this way...
28 KB (2,138 words) - 07:52, 1 May 2024
and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers"...
20 KB (1,911 words) - 13:28, 31 March 2024
known. However, evidence indicates that it activates the neuron receptor TRPM8, which appears to keep minor pain signals in the brain from communicating...
9 KB (674 words) - 14:43, 15 June 2024
supermice). Another mouse had the TRPM8 receptor blocked or removed in a study involving capsaicin and menthol. With the TRPM8 receptor removed, the mouse was...
14 KB (1,707 words) - 10:40, 24 January 2024
Proprioception – Sense of self-movement, force, and body position The TRPV1 and TRPM8 receptors play key roles in the perception of heat and cold. "Can You Feel...
8 KB (899 words) - 22:53, 16 June 2024
effect from angiotensin converting enzyme polymorphisms on migraine. The TRPM8 gene, which codes for a cation channel, has been linked to migraines. The...
100 KB (10,210 words) - 15:28, 4 July 2024
Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro". Evidence-Based Complementary and Alternative Medicine...
2 KB (139 words) - 21:29, 24 October 2021
β-caryophyllene/caryophyllene oxide, to inhibit transient receptor potential melastatin 8 (TRPM8), an archetypical cold-activated ion channel of mammals. In an in vitro...
26 KB (2,515 words) - 21:28, 26 April 2024
Hyperalgesia - an increased sensitivity to pain caused by sensory ion channel, TRPM8, which is typically responds to temperatures between 23 and 26 degrees,...
29 KB (3,289 words) - 05:52, 24 June 2024
pain threshold are unknown at this time. The cool stimuli are sensed by TRPM8 channels. Its C-terminal domain differs from the heat sensitive TRPs. Although...
24 KB (2,854 words) - 11:55, 27 April 2024