Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma and glioma. It is a MEK inhibitor...

rash, joint pain, fever and tiredness. When taken in combination with trametinib, the most common side effects include fever, tiredness, nausea, chills...

BRAF inhibitors, such as vemurafenib and dabrafenib and a MEK inhibitor trametinib are the most effective, approved treatments for BRAF positive melanoma...

of NSCLC) can be treated by dabrafenib combined with the MEK inhibitor trametinib; those with activated ROS1 (around 1% of NSCLC) can be inhibited by crizotinib...

evaluated as a combination treatment against solid tumors together with trametinib in a clinical trial sponsored by the National Cancer Institute. In this...

BRAF inhibitors, such as vemurafenib and dabrafenib; or a MEK inhibitor trametinib may be used. When arising in the nailbed of a digit, the evidence suggests...

BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. Important prognosis factors for nodular melanoma include: Thickness Ulceration...

are tyrosine kinase inhibitors that may also cause MG), dabrafenib, and trametinib; 3) antipsychotic drugs, i.e., chlorpromazine, pimozide, thioridazine...

metastatic melanoma that harbors BRAF V600E mutation MEK inhibitors (trametinib, MEK162) are used in experiments, often in combination with BRAF inhibitors...

Rosuvastatin Crestor 1.37 in hemodialysis patients Lisinopril Prinivil and others 1.38 Ivacaftor Kalydeco 2.2–2.9 Trametinib Mekinist 6.0 at 2 mg once daily...

thyroid cancer harboring such mutations. The combination of dabrafenib and trametinib has shown significant increases in overall survival and has been approved...

Fecher, Leslie A.; et al. (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial"....

chemotherapeutic treatment, dacarbazine. Dabrafenib in combination with trametinib was approved by FDA in June 2022 for treatment of all metastatic BRAF...

BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. In February 2024, the Food and Drug Administration approved the first...

at Moffitt Cancer Center discovered two monotherapy drugs – Mekinist (trametinib) and Tafinlar (dabrafenib) – can be safely combined to overcome or delay...

cobimetinib, CI-1040, PD0325901, binimetinib (MEK162), selumetinib, and trametinib (GSK1120212) It has been found that acupoint-moxibustion has a role in...

Ceritinib L01ED03 Alectinib L01ED04 Brigatinib L01ED05 Lorlatinib L01EE01 Trametinib L01EE02 Cobimetinib L01EE03 Binimetinib L01EE04 Selumetinib L01EE05 Mirdametinib...

for medical use in the United States in September 2020. Dabrafenib and trametinib have been approved as tissue-agnostic drugs for solid tumors that are...

Ruxolitinib MAP2K (MEK) Binimetinib Cobimetinib Mirdametinib Selumetinib Trametinib EML4-ALK Crizotinib Entrectinib Lorlatinib Bruton's (BTK) Acalabrutinib...

Lilly/Boehringer) tralokinumab (INN) tralonide (INN) tramadol (INN) tramazoline (INN) trametinib (USAN, INN) tramiprosate (USAN) Trancopal Trandate trandolapril (INN)...

include uveal melanoma (failed), and differentiated thyroid carcinoma. Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma. Also studied...

including Octreotide, Sirolimus, Anti-plasmin and, at least in one case, Trametinib. Dog breeds commonly affected by lymphangiectasia and/or protein-losing...

inhibitors, such as vemurafenib and dabrafenib; and an MEK inhibitor trametinib. Melanoma List of cutaneous conditions James, William D.; Berger, Timothy...

Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Trametinib Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Dabrafenib...

including Octreotide, Sirolimus, Anti-plasmin and, at least in one case, Trametinib. The disease was first reported in 1961 by T.A. Waldmann. He described...

can be tried. Or a BRAF inhibitor can be restarted plus MEK inhibitors trametinib or cobimetinib. Interferon-alpha is an immune system hormone that is very...

trial results compared vemurafenib with the combination of dabrafenib and trametinib for metastatic melanoma. Vemurafenib was approved in the United States...

human patients with a kidney disease. By combining doses of lithium, trametinib and rapamycin into a single treatment, researchers extend the lifespan...

ALK inhibitors with MEK inhibitors: brigatinib+binimetinib, ceritinib+trametinib, and alectinib+cobimetinib. Results for the last two are expected around...

retinoids to relieve symptoms but it may increase pain. Selumetinib and trametinib have been shown to reduce and control tumor growth in people with neurofibromatosis...