• Thumbnail for ATM serine/threonine kinase
    ATM serine/threonine kinase or Ataxia-telangiectasia mutated, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand...
    50 KB (5,639 words) - 20:54, 11 March 2024
  • Thumbnail for Serine/threonine-specific protein kinase
    A serine/threonine protein kinase (EC 2.7.11.-) is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid...
    14 KB (1,210 words) - 13:35, 14 June 2024
  • Company (NZX ticker symbol ATM) Apollo Telescope Mount, a solar observatory ATM serine/threonine kinase, a serine/threonine kinase activated by DNA damage...
    4 KB (504 words) - 10:12, 9 June 2024
  • Thumbnail for Berzosertib
    Rad3 related (ATR) and with lower potency as an inhibitor of ATM serine/threonine kinase (ATM). These enzymes are both involved in detecting DNA damage as...
    4 KB (402 words) - 21:58, 29 March 2024
  • Thumbnail for Ataxia telangiectasia and Rad3 related
    Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme...
    28 KB (3,425 words) - 20:27, 11 March 2024
  • Thumbnail for Phosphoinositide 3-kinase
    (DNA-PK) and mammalian target of rapamycin (mTOR). They are protein serine/threonine kinases. The various 3-phosphorylated phosphoinositides that are produced...
    32 KB (3,463 words) - 17:34, 20 November 2023
  • Thumbnail for Parkinson's disease
    Lewy body aggregation. ASyn activates ATM serine/threonine kinase, a major DNA damage-repair signaling kinase, and non-homologous end joining DNA repair...
    170 KB (17,935 words) - 09:17, 17 July 2024
  • Thumbnail for CHEK2
    CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell...
    28 KB (2,797 words) - 01:48, 26 March 2024
  • Thumbnail for DNA-PKcs
    the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase consisting of a single polypeptide...
    33 KB (3,787 words) - 03:21, 17 June 2024
  • phosphorylation of the kinase by itself. In eukaryotes, this process occurs by the addition of a phosphate group to serine, threonine or tyrosine residues...
    19 KB (2,321 words) - 21:42, 5 January 2024
  • Thumbnail for CHEK1
    Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates...
    30 KB (3,340 words) - 01:47, 26 March 2024
  • Thumbnail for MTOR inhibitors
    which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR...
    57 KB (6,278 words) - 05:05, 3 June 2024
  • caused by mutations in the ATM (ATM serine/threonine kinase or ataxia–telangiectasia mutated) gene, which was cloned in 1995. ATM is located on human chromosome...
    80 KB (10,530 words) - 11:14, 15 July 2024
  • Thumbnail for Stephen Jackson (biologist)
    paradigm for Jackson's later work on DNA-damage signalling by the ATM serine/threonine kinase and ATR (Ataxia telangiectasia and Rad3 related), and his studies...
    23 KB (1,849 words) - 02:18, 18 June 2024
  • Thumbnail for RIPK1
    Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In...
    35 KB (4,148 words) - 17:13, 8 June 2024
  • cycle regulator, retinoblastoma 1 ); and ATM (located at 11q22.3 and encoding ATM serine/threonine kinase, a kinase that regulates the activity of various...
    21 KB (2,700 words) - 00:49, 3 December 2023
  • Thumbnail for SMG1
    Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. SMG1 belongs to the phosphatidylinositol 3-kinase-related...
    9 KB (1,216 words) - 16:23, 12 May 2024
  • following four domains: N-terminus FRAP-ATM- TRRAP (FAT) domain, Pfam PF02259 kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus...
    2 KB (106 words) - 09:29, 23 October 2022
  • Thumbnail for NPAT (gene)
    3-phosphate dehydrogenase and POU2F1. ATM serine/threonine kinase, also located at 11p22.3, so the location is "ATM locus" GRCh38: Ensembl release 89: ENSG00000149308...
    7 KB (929 words) - 21:51, 25 May 2024
  • Thumbnail for HIPK2
    protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically...
    33 KB (3,894 words) - 01:47, 10 March 2024
  • mutated (ATM) serine/threonine kinase which is an enzyme involved in the repair of double stranded breaks caused by ionizing radiation. ATM phosphorylates...
    27 KB (3,620 words) - 00:08, 18 August 2023
  • Thumbnail for TLK2
    Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene. The Tousled-like kinases, first described in Arabidopsis...
    8 KB (995 words) - 11:15, 4 March 2023
  • Thumbnail for ZNF821
    the Serine at position 2 and the Threonine at position 7. It is also predicted by several sources to have further phosphorylation sites of the Serine at...
    14 KB (1,223 words) - 20:16, 10 May 2024
  • Thumbnail for PPP2R2A
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene...
    11 KB (1,393 words) - 01:53, 23 December 2023
  • Thumbnail for G1/S transition
    protein dimer made up of cyclin and cyclin-dependent kinase (Cdk), a serine and threonine kinase, which come together at different points in the cycle...
    13 KB (1,628 words) - 01:58, 3 December 2023
  • Thumbnail for DNA repair
    phosphatidylinositol 3-kinase (PI3K)-like protein kinase, proliferating cell nuclear antigen (PCNA)-like group, two serine/threonine(S/T) kinases and their adaptors...
    128 KB (15,837 words) - 04:28, 8 July 2024
  • Thumbnail for Transforming growth factor beta
    lineages. Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors. TGF-β receptors are composed...
    70 KB (8,485 words) - 08:12, 19 May 2024
  • Thumbnail for TLK1
    Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene. The Tousled-like kinases, first described in Arabidopsis...
    9 KB (1,213 words) - 17:45, 11 January 2024
  • Thumbnail for CSNK1D
    member of the CK1 (formerly named casein kinase 1) family of serine/threonine specific eukaryotic protein kinases encompassing seven distinct isoforms (CK1α...
    118 KB (14,738 words) - 05:32, 3 June 2024
  • survival within the host. J Biol Chem. 289, 13858 – 13875. Serine/threonine-specific protein kinase Phosphorylation India portal Biology portal Medicine portal...
    7 KB (666 words) - 08:00, 12 May 2024