of GRB2, phospholipase C γ (PLC-γ), p85, and SHP2. GAB1 is a key coordinator of the cellular responses to MET and binds the MET intracellular region with...

c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter...

pregnancy. c-MET may interact with FoxM1, a molecule important in the cell cycle, as FOXM1 levels decrease when c-MET is not present. Additionally, c-MET may...

tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by platelets, and mesenchymal...

muscular defects. Associated Genetic Factors: PAX3 and c-Met Mutations in PAX3 can cause a failure in c-Met expression. Such a mutation would result in a lack...

The Meteorological Office, abbreviated as the Met Office, is the United Kingdom's national weather and climate service. It is an executive agency and...

hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal...

The New York Mets are an American professional baseball team based in the New York City borough of Queens. The Mets compete in Major League Baseball (MLB)...

How I Met Your Mother (often abbreviated as HIMYM) is an American sitcom created by Craig Thomas and Carter Bays for CBS. The series, which aired from...

The Met Gala, formally called the Costume Institute Benefit, is the annual haute couture fundraising festival held for the benefit of the Metropolitan...

hepatocellular carcinoma. It is a small-molecule tyrosine-kinase inhibitor (TKI) of c-Met (HGFR) and VEGFR2, and also inhibits AXL, RET, and FLT3. It was discovered...

Centre for Development of Advanced Computing (C-DAC) Centre for Materials for Electronics Technology (C-MET) National Institute of Electronics and Information...

treatment of non-small cell lung carcinoma (NSCLC). Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved...

The name of the club was changed to Leeds Met Carnegie during the early part of the 1990s. In 2004, Leeds Met left the Northern Universities League for...

computing C-DAC branches and training centres include: C-DAC Pune (Headquarters) C-DAC Mumbai C-DAC Bangalore C-DAC Chennai C-DAC Delhi C-DAC Kolkata C-DAC...

(Baricitinib), and Iclusig (ponatinib). In 2013, Novartis acquired Incyte's c-Met inhibitor capmatinib (INC280, INCB028060), which is marketed under the brand...

Milano-Bicocca). The journal was formed by the merger of Journal of Physics C: Solid State Physics and Journal of Physics F: Metal Physics in 1989. This...

kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis. A lack of c-met disrupts secondary...

cancer. Vebreltinib selectively binds to c-Met, preventing its phosphorylation and thereby disrupting c-Met signal transduction pathways. In China, it...

example, only one insulin-like receptor exists in the nematode C. elegans. Additionally, C. elegans do not have specialized organs such as the (Islets of...

E-cadherin. CDH1 (gene) has been shown to interact with CBLL1, CDC27, CDH3, C-Met, CTNND1, CTNNB1, CTNNA1 FOXM1, HDAC1, HDAC2, IQGAP1, FYN, NEDD9, Plakoglobin...

Metters is a surname. Notable people with the surname include: Alfred Metters (c. 1863–1918), Australian Baptist minister and chaplain during WWI Chris...

small drug inhibitor of C-Met, as well a potential monoclonal antibody against hereditary gingival fibromatosis (HGF) and C-Met. Hydroxytyrosol Oleuropein...

of the tumour and prognosis of the patient. Crizotinib (also a ROS1 and c-MET inhibitor) was approved in Aug 2011 by the US FDA for ALK-positive NSCLC...

in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C) which are active in angiogenesis and endothelial cell growth, and...

The MetLife Building (also 200 Park Avenue and formerly the Pan Am Building) is a skyscraper at Park Avenue and 45th Street, north of Grand Central Terminal...

Tpr leucine zipper. The Tpr-Met fusion protein lacks the extracellular, transmembrane and juxtamembrane domains of c-Met receptor, and has gained the...

Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. (May 2007). "MET amplification leads to gefitinib resistance in lung cancer...

the receptor tyrosine kinase c-MET of hepatocyte growth factor. However, activation of the oncogenic pathway in the MET gene will manifest invasion, anti-apoptosis...

hyperactivity of ErbB-3. This is linked to an acquired overexpression of c-MET, which phosphorylates ErbB-3, which in turn activates the AKT pathway. Panitumumab...