CRISPR (/ˈkrɪspər/) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic...
128 KB (13,448 words) - 03:26, 19 August 2024
CRISPR gene editing (CRISPR, pronounced /ˈkrɪspər/ "crisper", refers to "clustered regularly interspaced short palindromic repeats") is a genetic engineering...
170 KB (19,936 words) - 11:24, 2 September 2024
CRISPR RNA or crRNA is a RNA transcript from the CRISPR locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats - CRISPR associated...
10 KB (1,149 words) - 06:02, 17 June 2024
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. It was one of the first companies formed to utilize...
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Cas9 (redirect from CRISPR/Cas9)
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense...
43 KB (5,610 words) - 21:17, 2 May 2024
February 19, 1964) is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and...
66 KB (5,701 words) - 19:12, 9 September 2024
CRISPR-Display (CRISP-Disp) is a modification of the CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats) system for genome editing...
16 KB (2,133 words) - 12:04, 22 March 2024
CRISPR activation (CRISPRa) is a type of CRISPR tool that uses modified versions of CRISPR effectors without endonuclease activity, with added transcriptional...
21 KB (2,672 words) - 09:24, 16 August 2024
Anti-CRISPR (Anti-Clustered Regularly Interspaced Short Palindromic Repeats or Acr) is a group of proteins found in phages, that inhibit the normal activity...
32 KB (3,691 words) - 06:48, 24 August 2024
CRISPR interference (CRISPRi) is a genetic perturbation technique that allows for sequence-specific repression of gene expression in prokaryotic and eukaryotic...
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He Jiankui affair (redirect from CRISPR baby)
standard in vitro fertilisation services and in addition, use of CRISPR gene editing (CRISPR/Cas9), a technology for modifying DNA. The embryos' genomes were...
103 KB (11,578 words) - 14:28, 2 September 2024
(gRNAs) for use with the CRISPR/Cas gene editing system. The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases)...
16 KB (1,283 words) - 11:02, 29 August 2024
Genome-wide CRISPR-Cas9 knockout screens aim to elucidate the relationship between genotype and phenotype by ablating gene expression on a genome-wide...
55 KB (6,164 words) - 23:47, 3 December 2023
The CRISPR Journal is a peer-reviewed scientific journal published every three months by Mary Ann Liebert. It covers research on all aspects of CRISPR research...
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thereby preventing the CRISPR locus from being targeted and destroyed by the CRISPR-associated nuclease. In a bacterial genome, CRISPR loci contain "spacers"...
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Cas12a (redirect from CRISPR/Cas12a)
(CRISPR-associated protein 12a, previously known as Cpf1) is a subtype of Cas12 proteins and an RNA-guided endonuclease that forms part of the CRISPR system...
13 KB (1,530 words) - 21:01, 18 August 2024
Emmanuelle Charpentier (section CRISPR/Cas9)
Chemistry "for the development of a method for genome editing" (through CRISPR). This was the first science Nobel Prize ever won by two women only. Born...
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CRISPR-associated transposons or CASTs are mobile genetic elements (MGEs) that have evolved to make use of minimal CRISPR systems for RNA-guided transposition...
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diagnostic tests using CRISPR-Cas12a and CRISPR-based therapies using its proprietary ultra-small CRISPR systems. Several CRISPR-Cas systems identified...
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Guide RNA (section CRISPR In Prokaryotes)
used for gene editing. In bacteria and archaea, gRNAs are a part of the CRISPR-Cas system that serves as an adaptive immune defense that protects the organism...
30 KB (3,628 words) - 15:29, 5 August 2024
Genome editing (section CRISPR)
meganucleases—were selected by Nature Methods as the 2011 Method of the Year. The CRISPR-Cas system was selected by Science as 2015 Breakthrough of the Year. As...
78 KB (9,362 words) - 13:30, 27 July 2024
Francisco Mojica (section The discovery of CRISPR)
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). These were later developed into the first widespread genome editing tool, CRISPR-Cas9...
20 KB (1,955 words) - 15:49, 15 October 2023
technologies such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), are also improving the nutrition, taste and yield of crops. There...
32 KB (3,576 words) - 19:10, 19 August 2024
on pooled genetic perturbation screens. Perturb-seq combines multiplexed CRISPR mediated gene inactivations with single cell RNA sequencing to assess comprehensive...
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in Texas on protein evolution, including that of CRISPR, He learned gene-editing techniques (CRISPR/Cas9) as a postdoctoral researcher at Stanford University...
61 KB (6,078 words) - 06:55, 14 August 2024
Designer baby (section CRISPR/Cas9)
homology directed repair. The CRISPR/Cas9 system (CRISPR – Clustered Regularly Interspaced Short Palindromic Repeats, Cas9 – CRISPR-associated protein 9) is...
71 KB (8,210 words) - 14:25, 2 September 2024
Human genetic enhancement (section CRISPR/Cas9)
benefits of revolutionary tools like CRISPR are endless. For example, because it can be applied directly in the embryo, CRISPR/Cas9 reduces the time required...
95 KB (10,491 words) - 11:26, 7 September 2024
Germline mutation (section CRISPR/Cas9 editing)
initiates cellular repair processes, similar to that of CRISPR/Cas9 DNA editing. Compared to CRISPR/Cas9, the therapeutic applications of this technology...
25 KB (3,085 words) - 14:19, 5 August 2024
Site-directed mutagenesis (redirect from CRISPR mutagenesis)
alternative to site-directed mutagenesis. Since 2013, the development of the CRISPR/Cas9 technology, based on a prokaryotic viral defense system, has also allowed...
25 KB (2,980 words) - 07:09, 8 September 2024
trial using CRISPR-Cas9 gene editing of T cells in patients with refractory cancer demonstrates that, according to their study, such CRISPR-based therapies...
280 KB (24,488 words) - 03:15, 7 August 2024