is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and...
24 KB (2,696 words) - 04:11, 13 August 2024
A CYP17A1 inhibitor is a type of drug which inhibits the enzyme CYP17A1. It may inhibit both of the functions of the enzyme, 17α-hydroxylase and 17,20-lyase...
4 KB (351 words) - 13:33, 24 January 2024
List of antiandrogens (section CYP17A1 inhibitors)
receptor (AR), androgen synthesis inhibitors like 5α-reductase inhibitors and CYP17A1 inhibitors, and antigonadotropins like GnRH analogues, estrogens, and progestogens...
5 KB (254 words) - 18:23, 18 September 2023
Abiraterone acetate (category CYP17A1 inhibitors)
by suppressing the production of androgens – specifically it inhibits CYP17A1 – and thereby decreases the production of testosterone. In doing so, it...
49 KB (4,213 words) - 01:54, 2 September 2024
17α-hydroxylase (CYP17A1). Using this pathway, termed Δ5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) via 17,20-lyase (CYP17A1). DHEA is...
21 KB (2,059 words) - 07:45, 3 June 2024
due to variants in CYP17A1, cytochrome b5, and POR may also disrupt the backdoor pathway to DHT, as the 17,20-lyase activity of CYP17A1 is required for both...
79 KB (8,729 words) - 10:41, 27 September 2024
congenital adrenal hyperplasia (CAH) resulting from a mutation in the gene CYP17A1, which produces the enzyme 17α-hydroxylase. It causes decreased synthesis...
16 KB (1,830 words) - 22:53, 22 April 2024
22-desmolase; converts cholesterol to pregnenolone. 17,20-Desmolase, also called CYP17A1 or 17α-hydroxylase; converts pregnenolone to 17α-hydroxypregnenolone, progesterone...
1 KB (148 words) - 17:32, 15 August 2023
pregnenolone. In the next step, two additional carbon atoms are removed by the CYP17A1 (17α-hydroxylase/17,20-lyase) enzyme in the endoplasmic reticulum to yield...
149 KB (15,717 words) - 14:45, 15 September 2024
mutations in genes, including HSD3B2 (3β-hydroxysteroid dehydrogenase 2), CYP17A1 (17α-hydroxylase/17,20-lyase), CYP11A1 (P450scc; cholesterol side-chain...
45 KB (4,577 words) - 20:52, 14 August 2024
deficiency is a rare disorder caused by genetic mutations in the gene CYP17A1, while not affecting 17α-hydroxylase. Isolated 17,20 lyase deficiency is...
11 KB (984 words) - 04:13, 10 March 2024
Seviteronel (category CYP17A1 inhibitors)
the treatment of prostate cancer and breast cancer. It is a nonsteroidal CYP17A1 inhibitor and works by inhibiting the production of androgens and estrogens...
11 KB (882 words) - 12:00, 13 July 2024
significantly affect their binding to CYP17A1. Furthermore, it has been observed that the lyase activity of CYP17A1 is impaired by the C11-hydroxyl (-OH)...
5 KB (474 words) - 22:30, 10 April 2024
antiandrogens; androgen synthesis inhibitors can be further divided mostly into CYP17A1 inhibitors and 5α-reductase inhibitors; and antigonadotropins can be further...
159 KB (15,079 words) - 15:42, 24 September 2024
Spironolactone (category CYP17A1 inhibitors)
by spironolactone and consequent changes in sex hormone levels. Indeed, CYP17A1 genotype is associated with polymenorrhea. Regardless of their mechanism...
181 KB (17,316 words) - 05:17, 7 September 2024
pinocembrin and acacetin.[better source needed][better source needed] CYP17A1 inhibitor Estrogen deprivation therapy Selective estrogen receptor degrader...
21 KB (2,055 words) - 21:02, 29 September 2024
Flutamide (category CYP17A1 inhibitors)
rats. Flutamide and hydroxyflutamide have been found in vitro to inhibit CYP17A1 (17α-hydroxylase/17,20-lyase), an enzyme which is required for the biosynthesis...
99 KB (10,979 words) - 17:57, 1 September 2024
performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in...
5 KB (360 words) - 19:10, 8 March 2023
is metabolized into androstadienol by the 16-ene-synthetase activity of CYP17A1. Androstadienol is then sequentially converted into androstenol by 3β-hydroxysteroid...
8 KB (693 words) - 12:26, 20 March 2024
Cyproterone acetate (category CYP17A1 inhibitors)
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an...
139 KB (13,859 words) - 08:44, 8 September 2024
Danazol (category CYP17A1 inhibitors)
Danazol, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema...
46 KB (3,954 words) - 04:46, 8 April 2024
5α-reductase inhibitors Discovery and development of 5α-reductase inhibitors CYP17A1 inhibitor Neurosteroidogenesis inhibitor Ulrike Blume-Peytavi; David A...
31 KB (3,433 words) - 01:04, 23 June 2024
side-chain cleavage enzyme (CYP11A1; P450scc) and 17α-hydroxylase/17,20-lyase (CYP17A1), with pregnenolone and 17α-hydroxypregnenolone as intermediates. It is...
42 KB (3,935 words) - 04:01, 30 April 2024
17α-OHP is derived from progesterone via 17α-hydroxylase (encoded by CYP17A1). 17α-OHP increases in the third trimester of pregnancy primarily due to...
14 KB (1,126 words) - 10:08, 7 July 2024
for inhibition of CYP26A1 over other steroid-metabolizing enzymes like CYP17A1 (17α-hydroxylase/17,20-lyase) and aromatase (CYP19A1). "Talarozole". AdisInsight...
5 KB (322 words) - 14:01, 9 January 2024
Ketoconazole (category CYP17A1 inhibitors)
Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number...
50 KB (4,379 words) - 21:52, 16 September 2024
Troglitazone (category CYP17A1 inhibitors)
Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with...
20 KB (2,044 words) - 13:18, 15 August 2024
Mifepristone (category CYP17A1 inhibitors)
Mifepristone, also known by its developmental code name RU-486, is a medication typically used in combination with misoprostol to bring about a medical...
125 KB (11,569 words) - 02:29, 11 September 2024
N, Audí L (29 April 2018). "Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel...
156 KB (14,658 words) - 06:30, 29 September 2024
bicalutamide, 5α-reductase inhibitors such as finasteride and dutasteride, CYP17A1 inhibitors such as abiraterone acetate, gonadotropin-releasing hormone...
7 KB (561 words) - 01:38, 21 May 2024