Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a...

Outcome measure, a measure used as an endpoint in research Clinical endpoint, in clinical research, a disease, symptom, or sign that constitutes one of...

In clinical trials, a surrogate endpoint (or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint...

outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is...

Clinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and other types of research...

oscillations are emerging as secondary endpoints in clinical trials and in quantifying effects in pre-clinical studies. These biomarkers are often named...

static condition. Progressive disease can also be a clinical endpoint i.e. an endpoint in a clinical trial. A progressive disease should not be confused...

early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of...

solely on clinical endpoints are very costly as they have long durations and tend to need large numbers of patients. In contrast to clinical endpoints, surrogate...

used. The NNT is an important measure in pharmacoeconomics. If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high...

types of survival rates (discussed below). They often serve as endpoints of clinical trials and should not be confused with mortality rates, a population...

effectiveness and regulatory approval is controversial. It is often used as a clinical endpoint in randomized controlled trials for cancer therapies. It is a metric...

interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs)...

endpoint time ratio, which likely would have been close to unity, i.e. mortality was largely the same regardless of group membership and clinically insignificant...

participation which means taking part in research, for example taking a drug in a clinical trial. Public involvement in medical research can be defined as research...

determining the initial dose regimen to be given to a patient, based on clinical endpoint and on established population pharmacokinetic-pharmacodynamic (PK/PD)...

design Block design Box–Behnken design Central composite design Clinical trial Clinical study design Computer experiment Control variable Controlling for...

patients. The clinical endpoint is death from any cause within 30 days. The InTIME II database includes 15078 patients with full baseline clinical data available...

planned clinical endpoint, but the trial has been criticized as being underpowered, limiting endovascular options, and comparing inappropriate endpoints. As...

Kleiman, Evan M. (2020). "Suicidal thinking as a valuable clinical endpoint". eClinicalMedicine. 23: 100399. doi:10.1016/j.eclinm.2020.100399. ISSN 2589-5370...

expose the patient to harms while providing therapeutic benefits. If a clinical endpoint is devastating enough without the drug (e.g. death, heart attack)...

theory The Outcome, a 2005 Spanish film An outcome measure (or endpoint) in a clinical trial The National Outcomes adopted as targets by the Scottish...

primary clinical endpoint data is August 2019. As of October 2020, there are multiple therapeutic HPV vaccines in active development and in clinical trials...

– circumoral paresthesia – clade – clinical endpoint – clinical latency – clinical practice guidelines – clinical trial – clinicaltrials.gov – cloning...

misusing statistics to exaggerate treatment benefits Setting a dubious clinical endpoint in research Advertising a treatment as without side effect Advertising...

based on extensive experiments on goats and other animals using a clinical endpoint of symptomatic decompression sickness. The model, commented as "a...

understanding of the trial drug characteristics, or when specific clinical endpoints were measured rather than using surrogate outcomes. Umscheid, Craig...

randomised, placebo-controlled double-blind clinical trials. However absolutely no effect on clinical endpoints such as CVD or mortality was demonstrated...

or plaques with central superficial atrophy. Atrophic CLP is the clinical endpoint of chronic annular or hypertrophic LP with atrophic lesions. The use...

studied is beneficial. The endpoints of a clinical trial are usually included in the study objectives. Some examples of endpoints are survival, improvements...