immunology, clonal deletion is the process of removing T and B lymphocytes from the immune system repertoire. The process of clonal deletion helps prevent...
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pre-existing clones of lymphocytes, which expand in response to specific antigen (process called "clonal selection"). This specific clonal army then combats...
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Peripheral tolerance (section Peripheral deletion)
food antigens and allergens. Self reactive cells are subject to clonal deletion or clonal diversion. Both processes of peripheral tolerance control the...
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anemone, also called clonal anemone Vegetative cloning, a form of asexual reproduction in plants Clonal reproduction Clonal deletion, a process by which...
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strongly to self-antigen, then the B cell undergoes one of four fates: clonal deletion, receptor editing, anergy, or ignorance (B cell ignores signal and...
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receptor. Both activated T cells and B cells express Fas and undergo clonal deletion by the AICD mechanism. Activated T cells that express both Fas and...
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bind a self peptide, then they are signaled to apoptose (process of clonal deletion). The thymic epithelial cells display self antigen to the T cells to...
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In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of...
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ability to deal with these autoreactive clones via mediation of the processes of central tolerance, namely clonal deletion or T regulatory cells selection, respectively...
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tolerance. Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones. Receptor editing is another mechanism...
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In mice models, most mother's fetal-specific CD8+ T cells undergo clonal deletion and express low levels of chemokine receptors and ligands – this prevents...
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is allowed to proliferate or is killed off through a process called clonal deletion. Normally, the immune system is able to recognize and ignore the body's...
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Three hypotheses have gained widespread attention among immunologists: Clonal deletion theory, proposed by Burnet, according to which self-reactive lymphoid...
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processes of central tolerance take place in thymic medulla, namely clonal deletion (recessive tolerance) and T Regulatory cells selection (dominant tolerance)...
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16p11.2 deletion syndrome is a rare genetic condition caused by microdeletion on the short arm of chromosome 16. Most affected individuals experience global...
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Sprent, Jonathan, and Susan R. Webb. "Intrathymic and extrathymic clonal deletion of T cells." Current opinion in immunology 7.2 (1995): 196-205. Crotty...
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Cholinergic anti-inflammatory pathway CLIP (protein) Clonal anergy Clonal deletion Clonal selection Clone (cell biology) CMKLR1 Colony stimulating factor 1...
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abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction". Scandinavian Journal of Immunology...
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were the first to propose the deletion of self-reactive lymphocytes to establish tolerance, now termed clonal deletion. Burnet and Medawar were ultimately...
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dendritic cell with T cell receptors on the T cell. This can induce T cell clonal deletion, T cell anergy or the proliferation of regulatory T cells (Tregs)....
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Whitacre CC, Liu Y, Bai XF (July 2008). "Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway". Journal of Immunology....
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activity is selective but is not T-cell receptor mediated. Both clonal anergy and clonal deletion have been shown to operate in vetoed T cells. The veto cell...
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yeast deletion project, formally the Saccharomyces Genome Deletion Project, is a project to create data for a near-complete collection of gene-deletion mutants...
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maintenance of central and peripheral tolerance through induction of T cell clonal deletion, T cell anergy and generation and activation of regulatory T (Treg)...
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anti-CD4 monoclonal antibodies, demonstrating that neither thymus nor clonal deletion is necessary to induce tolerance. In 1989 was successfully induced...
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Most T cells are, in time, eliminated in the thymus by a process of clonal deletion. However, some of them escape this process and are then "mopped up"...
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Cross-reactivity Tolerance Central tolerance Peripheral tolerance Clonal anergy Clonal deletion Tolerance in pregnancy Immunodeficiency Antigen Antigenicity...
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chromosome deletion (specifically Xp21) was the underlying cause of all of these features, researchers were able to use this information to clone the genes...
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mice: deletion of nonmatare CD4+8+ thymoqttes. Nature 333, 742-746 (1988); Swat, W., Ignatowicz, L., von Boehmer, H. and Kisielow, P.: Clonal deletion of...
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del(5q) MDS. An independent line of investigation characterized and defined clonal hematopoiesis of indeterminate potential (CHIP) as a precursor state for...
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